Signal propagation in sensing and reciprocating cellular systems with spatial and structural heterogeneity

25 Feb 2018 Hodgkinson Arran Uzé Giles Radulescu Ovidiu Trucu Dumitru

Sensing and reciprocating cellular systems (SARs) are important for the operation of many biological systems. Production in interferon (IFN) SARs is achieved through activation of the Jak-Stat pathway, and downstream upregulation of IFN regulatory factor (IRF)-3 and IFN transcription, but the role that high and low affinity IFNs play in this process remains unclear... (read more)

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