SpikeDeep-Classifier: A deep-learning based fully automatic offline spike sorting algorithm

Objective. Recent advancements in electrode designs and micro-fabrication technology has allowed existence of microelectrode arrays with hundreds of channels for single-cell recordings. In such electrophysiological recordings, each implanted micro-electrode can record the activities of more than one neuron in its vicinity. Recording the activities of multiple neurons may also be referred to as multiple unit activity. However, for any further analysis, the main goal is to isolate the activity of each recorded neuron and thus called single-unit activity. This process may also be referred to as spike sorting or spike classification. Recent approaches to extract SUA are time consuming, mainly due to the requirement of human intervention at various stages of spike sorting pipeline. Lack of standardization is another drawback of the current available approaches. Therefore, in this study we proposed a standard spike sorter: SpikeDeep-Classifier, a fully automatic spike sorting algorithm. Approach. We proposed a novel spike sorting pipeline, based on a set of supervised and unsupervised learning algorithms. We used supervised, deep learning-based algorithms for extracting meaningful channels and removing background activities (noise) from the extracted channels. We also showed that the process of clustering becomes straight-forward, once the noise/artifact is completely removed from the data. Therefore, in the next stage, we applied a simple clustering algorithm (K-mean) with predefined maximum number of clusters. Lastly, we used a similarity-based criterion to keep distinct clusters and merge similar-looking clusters. Main results. We evaluated our algorithm on a dataset collected from two different species (humans and non-human primates (NHPs)) without any retraining. We also validated our algorithm on two publicly available labeled datasets.

PDF Abstract
No code implementations yet. Submit your code now


  Add Datasets introduced or used in this paper

Results from the Paper

  Submit results from this paper to get state-of-the-art GitHub badges and help the community compare results to other papers.


No methods listed for this paper. Add relevant methods here