Unsupervised deconvolution of dynamic imaging reveals intratumor vascular heterogeneity

Intratumor heterogeneity is often manifested by vascular compartments with distinct pharmacokinetics that cannot be resolved directly by in vivo dynamic imaging. We developed tissue-specific compartment modeling (TSCM), an unsupervised computational method of deconvolving dynamic imaging series from heterogeneous tumors that can improve vascular phenotyping in many biological contexts... (read more)

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