no code implementations • 29 Apr 2024 • Khaled Saab, Tao Tu, Wei-Hung Weng, Ryutaro Tanno, David Stutz, Ellery Wulczyn, Fan Zhang, Tim Strother, Chunjong Park, Elahe Vedadi, Juanma Zambrano Chaves, Szu-Yeu Hu, Mike Schaekermann, Aishwarya Kamath, Yong Cheng, David G. T. Barrett, Cathy Cheung, Basil Mustafa, Anil Palepu, Daniel McDuff, Le Hou, Tomer Golany, Luyang Liu, Jean-Baptiste Alayrac, Neil Houlsby, Nenad Tomasev, Jan Freyberg, Charles Lau, Jonas Kemp, Jeremy Lai, Shekoofeh Azizi, Kimberly Kanada, SiWai Man, Kavita Kulkarni, Ruoxi Sun, Siamak Shakeri, Luheng He, Ben Caine, Albert Webson, Natasha Latysheva, Melvin Johnson, Philip Mansfield, Jian Lu, Ehud Rivlin, Jesper Anderson, Bradley Green, Renee Wong, Jonathan Krause, Jonathon Shlens, Ewa Dominowska, S. M. Ali Eslami, Katherine Chou, Claire Cui, Oriol Vinyals, Koray Kavukcuoglu, James Manyika, Jeff Dean, Demis Hassabis, Yossi Matias, Dale Webster, Joelle Barral, Greg Corrado, Christopher Semturs, S. Sara Mahdavi, Juraj Gottweis, Alan Karthikesalingam, Vivek Natarajan
We evaluate Med-Gemini on 14 medical benchmarks, establishing new state-of-the-art (SoTA) performance on 10 of them, and surpass the GPT-4 model family on every benchmark where a direct comparison is viable, often by a wide margin.
no code implementations • 18 Mar 2024 • Stephen R. Pfohl, Heather Cole-Lewis, Rory Sayres, Darlene Neal, Mercy Asiedu, Awa Dieng, Nenad Tomasev, Qazi Mamunur Rashid, Shekoofeh Azizi, Negar Rostamzadeh, Liam G. McCoy, Leo Anthony Celi, Yun Liu, Mike Schaekermann, Alanna Walton, Alicia Parrish, Chirag Nagpal, Preeti Singh, Akeiylah Dewitt, Philip Mansfield, Sushant Prakash, Katherine Heller, Alan Karthikesalingam, Christopher Semturs, Joelle Barral, Greg Corrado, Yossi Matias, Jamila Smith-Loud, Ivor Horn, Karan Singhal
Large language models (LLMs) hold immense promise to serve complex health information needs but also have the potential to introduce harm and exacerbate health disparities.
no code implementations • 22 Jan 2024 • Jan Freyberg, Abhijit Guha Roy, Terry Spitz, Beverly Freeman, Mike Schaekermann, Patricia Strachan, Eva Schnider, Renee Wong, Dale R Webster, Alan Karthikesalingam, Yun Liu, Krishnamurthy Dvijotham, Umesh Telang
In this paper we tackle a more subtle challenge: doctors take a targeted medical history to obtain only the most pertinent pieces of information; how do we enable AI to do the same?
no code implementations • 11 Jan 2024 • Tao Tu, Anil Palepu, Mike Schaekermann, Khaled Saab, Jan Freyberg, Ryutaro Tanno, Amy Wang, Brenna Li, Mohamed Amin, Nenad Tomasev, Shekoofeh Azizi, Karan Singhal, Yong Cheng, Le Hou, Albert Webson, Kavita Kulkarni, S Sara Mahdavi, Christopher Semturs, Juraj Gottweis, Joelle Barral, Katherine Chou, Greg S Corrado, Yossi Matias, Alan Karthikesalingam, Vivek Natarajan
The study included 149 case scenarios from clinical providers in Canada, the UK, and India, 20 PCPs for comparison with AMIE, and evaluations by specialist physicians and patient actors.
no code implementations • 30 Nov 2023 • Daniel McDuff, Mike Schaekermann, Tao Tu, Anil Palepu, Amy Wang, Jake Garrison, Karan Singhal, Yash Sharma, Shekoofeh Azizi, Kavita Kulkarni, Le Hou, Yong Cheng, Yun Liu, S Sara Mahdavi, Sushant Prakash, Anupam Pathak, Christopher Semturs, Shwetak Patel, Dale R Webster, Ewa Dominowska, Juraj Gottweis, Joelle Barral, Katherine Chou, Greg S Corrado, Yossi Matias, Jake Sunshine, Alan Karthikesalingam, Vivek Natarajan
Comparing the two assisted study arms, the DDx quality score was higher for clinicians assisted by our LLM (top-10 accuracy 51. 7%) compared to clinicians without its assistance (36. 1%) (McNemar's Test: 45. 7, p < 0. 01) and clinicians with search (44. 4%) (4. 75, p = 0. 03).
no code implementations • 30 Nov 2023 • Ryutaro Tanno, David G. T. Barrett, Andrew Sellergren, Sumedh Ghaisas, Sumanth Dathathri, Abigail See, Johannes Welbl, Karan Singhal, Shekoofeh Azizi, Tao Tu, Mike Schaekermann, Rhys May, Roy Lee, SiWai Man, Zahra Ahmed, Sara Mahdavi, Yossi Matias, Joelle Barral, Ali Eslami, Danielle Belgrave, Vivek Natarajan, Shravya Shetty, Pushmeet Kohli, Po-Sen Huang, Alan Karthikesalingam, Ira Ktena
Radiology reports are an instrumental part of modern medicine, informing key clinical decisions such as diagnosis and treatment.
no code implementations • 3 Aug 2023 • Isaac R. Galatzer-Levy, Daniel McDuff, Vivek Natarajan, Alan Karthikesalingam, Matteo Malgaroli
The current work investigates the capability of Large language models (LLMs) that are explicitly trained on large corpuses of medical knowledge (Med-PaLM 2) to predict psychiatric functioning from patient interviews and clinical descriptions without being trained to do so.
no code implementations • 26 Jul 2023 • Tao Tu, Shekoofeh Azizi, Danny Driess, Mike Schaekermann, Mohamed Amin, Pi-Chuan Chang, Andrew Carroll, Chuck Lau, Ryutaro Tanno, Ira Ktena, Basil Mustafa, Aakanksha Chowdhery, Yun Liu, Simon Kornblith, David Fleet, Philip Mansfield, Sushant Prakash, Renee Wong, Sunny Virmani, Christopher Semturs, S Sara Mahdavi, Bradley Green, Ewa Dominowska, Blaise Aguera y Arcas, Joelle Barral, Dale Webster, Greg S. Corrado, Yossi Matias, Karan Singhal, Pete Florence, Alan Karthikesalingam, Vivek Natarajan
While considerable work is needed to validate these models in real-world use cases, our results represent a milestone towards the development of generalist biomedical AI systems.
1 code implementation • 5 Jul 2023 • David Stutz, Ali Taylan Cemgil, Abhijit Guha Roy, Tatiana Matejovicova, Melih Barsbey, Patricia Strachan, Mike Schaekermann, Jan Freyberg, Rajeev Rikhye, Beverly Freeman, Javier Perez Matos, Umesh Telang, Dale R. Webster, YuAn Liu, Greg S. Corrado, Yossi Matias, Pushmeet Kohli, Yun Liu, Arnaud Doucet, Alan Karthikesalingam
In contrast, we propose a framework where aggregation is done using a statistical model.
1 code implementation • 16 May 2023 • Karan Singhal, Tao Tu, Juraj Gottweis, Rory Sayres, Ellery Wulczyn, Le Hou, Kevin Clark, Stephen Pfohl, Heather Cole-Lewis, Darlene Neal, Mike Schaekermann, Amy Wang, Mohamed Amin, Sami Lachgar, Philip Mansfield, Sushant Prakash, Bradley Green, Ewa Dominowska, Blaise Aguera y Arcas, Nenad Tomasev, Yun Liu, Renee Wong, Christopher Semturs, S. Sara Mahdavi, Joelle Barral, Dale Webster, Greg S. Corrado, Yossi Matias, Shekoofeh Azizi, Alan Karthikesalingam, Vivek Natarajan
Large language models (LLMs) have catalyzed significant progress in medical question answering; Med-PaLM was the first model to exceed a "passing" score in US Medical Licensing Examination (USMLE) style questions with a score of 67. 2% on the MedQA dataset.
no code implementations • 18 Apr 2023 • Ira Ktena, Olivia Wiles, Isabela Albuquerque, Sylvestre-Alvise Rebuffi, Ryutaro Tanno, Abhijit Guha Roy, Shekoofeh Azizi, Danielle Belgrave, Pushmeet Kohli, Alan Karthikesalingam, Taylan Cemgil, Sven Gowal
In our work, we show that learning realistic augmentations automatically from data is possible in a label-efficient manner using generative models.
no code implementations • 3 Feb 2023 • Annika Reinke, Minu D. Tizabi, Michael Baumgartner, Matthias Eisenmann, Doreen Heckmann-Nötzel, A. Emre Kavur, Tim Rädsch, Carole H. Sudre, Laura Acion, Michela Antonelli, Tal Arbel, Spyridon Bakas, Arriel Benis, Matthew Blaschko, Florian Buettner, M. Jorge Cardoso, Veronika Cheplygina, Jianxu Chen, Evangelia Christodoulou, Beth A. Cimini, Gary S. Collins, Keyvan Farahani, Luciana Ferrer, Adrian Galdran, Bram van Ginneken, Ben Glocker, Patrick Godau, Robert Haase, Daniel A. Hashimoto, Michael M. Hoffman, Merel Huisman, Fabian Isensee, Pierre Jannin, Charles E. Kahn, Dagmar Kainmueller, Bernhard Kainz, Alexandros Karargyris, Alan Karthikesalingam, Hannes Kenngott, Jens Kleesiek, Florian Kofler, Thijs Kooi, Annette Kopp-Schneider, Michal Kozubek, Anna Kreshuk, Tahsin Kurc, Bennett A. Landman, Geert Litjens, Amin Madani, Klaus Maier-Hein, Anne L. Martel, Peter Mattson, Erik Meijering, Bjoern Menze, Karel G. M. Moons, Henning Müller, Brennan Nichyporuk, Felix Nickel, Jens Petersen, Susanne M. Rafelski, Nasir Rajpoot, Mauricio Reyes, Michael A. Riegler, Nicola Rieke, Julio Saez-Rodriguez, Clara I. Sánchez, Shravya Shetty, Maarten van Smeden, Ronald M. Summers, Abdel A. Taha, Aleksei Tiulpin, Sotirios A. Tsaftaris, Ben van Calster, Gaël Varoquaux, Manuel Wiesenfarth, Ziv R. Yaniv, Paul F. Jäger, Lena Maier-Hein
Validation metrics are key for the reliable tracking of scientific progress and for bridging the current chasm between artificial intelligence (AI) research and its translation into practice.
1 code implementation • 26 Dec 2022 • Karan Singhal, Shekoofeh Azizi, Tao Tu, S. Sara Mahdavi, Jason Wei, Hyung Won Chung, Nathan Scales, Ajay Tanwani, Heather Cole-Lewis, Stephen Pfohl, Perry Payne, Martin Seneviratne, Paul Gamble, Chris Kelly, Nathaneal Scharli, Aakanksha Chowdhery, Philip Mansfield, Blaise Aguera y Arcas, Dale Webster, Greg S. Corrado, Yossi Matias, Katherine Chou, Juraj Gottweis, Nenad Tomasev, Yun Liu, Alvin Rajkomar, Joelle Barral, Christopher Semturs, Alan Karthikesalingam, Vivek Natarajan
To resolve this we introduce instruction prompt tuning, a parameter-efficient approach for aligning LLMs to new domains using a few exemplars.
Ranked #4 on Multiple Choice Question Answering (MCQA) on MedMCQA (Dev Set (Acc-%) metric)
no code implementations • 21 Jul 2022 • Alexander Brown, Nenad Tomasev, Jan Freyberg, YuAn Liu, Alan Karthikesalingam, Jessica Schrouff
Machine learning (ML) holds great promise for improving healthcare, but it is critical to ensure that its use will not propagate or amplify health disparities.
1 code implementation • 3 Jun 2022 • Lena Maier-Hein, Annika Reinke, Patrick Godau, Minu D. Tizabi, Florian Buettner, Evangelia Christodoulou, Ben Glocker, Fabian Isensee, Jens Kleesiek, Michal Kozubek, Mauricio Reyes, Michael A. Riegler, Manuel Wiesenfarth, A. Emre Kavur, Carole H. Sudre, Michael Baumgartner, Matthias Eisenmann, Doreen Heckmann-Nötzel, Tim Rädsch, Laura Acion, Michela Antonelli, Tal Arbel, Spyridon Bakas, Arriel Benis, Matthew Blaschko, M. Jorge Cardoso, Veronika Cheplygina, Beth A. Cimini, Gary S. Collins, Keyvan Farahani, Luciana Ferrer, Adrian Galdran, Bram van Ginneken, Robert Haase, Daniel A. Hashimoto, Michael M. Hoffman, Merel Huisman, Pierre Jannin, Charles E. Kahn, Dagmar Kainmueller, Bernhard Kainz, Alexandros Karargyris, Alan Karthikesalingam, Hannes Kenngott, Florian Kofler, Annette Kopp-Schneider, Anna Kreshuk, Tahsin Kurc, Bennett A. Landman, Geert Litjens, Amin Madani, Klaus Maier-Hein, Anne L. Martel, Peter Mattson, Erik Meijering, Bjoern Menze, Karel G. M. Moons, Henning Müller, Brennan Nichyporuk, Felix Nickel, Jens Petersen, Nasir Rajpoot, Nicola Rieke, Julio Saez-Rodriguez, Clara I. Sánchez, Shravya Shetty, Maarten van Smeden, Ronald M. Summers, Abdel A. Taha, Aleksei Tiulpin, Sotirios A. Tsaftaris, Ben van Calster, Gaël Varoquaux, Paul F. Jäger
The framework was developed in a multi-stage Delphi process and is based on the novel concept of a problem fingerprint - a structured representation of the given problem that captures all aspects that are relevant for metric selection, from the domain interest to the properties of the target structure(s), data set and algorithm output.
3 code implementations • 19 May 2022 • Shekoofeh Azizi, Laura Culp, Jan Freyberg, Basil Mustafa, Sebastien Baur, Simon Kornblith, Ting Chen, Patricia MacWilliams, S. Sara Mahdavi, Ellery Wulczyn, Boris Babenko, Megan Wilson, Aaron Loh, Po-Hsuan Cameron Chen, YuAn Liu, Pinal Bavishi, Scott Mayer McKinney, Jim Winkens, Abhijit Guha Roy, Zach Beaver, Fiona Ryan, Justin Krogue, Mozziyar Etemadi, Umesh Telang, Yun Liu, Lily Peng, Greg S. Corrado, Dale R. Webster, David Fleet, Geoffrey Hinton, Neil Houlsby, Alan Karthikesalingam, Mohammad Norouzi, Vivek Natarajan
These results suggest that REMEDIS can significantly accelerate the life-cycle of medical imaging AI development thereby presenting an important step forward for medical imaging AI to deliver broad impact.
no code implementations • 2 Feb 2022 • Jessica Schrouff, Natalie Harris, Oluwasanmi Koyejo, Ibrahim Alabdulmohsin, Eva Schnider, Krista Opsahl-Ong, Alex Brown, Subhrajit Roy, Diana Mincu, Christina Chen, Awa Dieng, YuAn Liu, Vivek Natarajan, Alan Karthikesalingam, Katherine Heller, Silvia Chiappa, Alexander D'Amour
Diagnosing and mitigating changes in model fairness under distribution shift is an important component of the safe deployment of machine learning in healthcare settings.
no code implementations • 16 Jun 2021 • Jessica Schrouff, Sebastien Baur, Shaobo Hou, Diana Mincu, Eric Loreaux, Ralph Blanes, James Wexler, Alan Karthikesalingam, Been Kim
While there are many methods focused on either one, few frameworks can provide both local and global explanations in a consistent manner.
1 code implementation • 12 Apr 2021 • Annika Reinke, Minu D. Tizabi, Carole H. Sudre, Matthias Eisenmann, Tim Rädsch, Michael Baumgartner, Laura Acion, Michela Antonelli, Tal Arbel, Spyridon Bakas, Peter Bankhead, Arriel Benis, Matthew Blaschko, Florian Buettner, M. Jorge Cardoso, Jianxu Chen, Veronika Cheplygina, Evangelia Christodoulou, Beth Cimini, Gary S. Collins, Sandy Engelhardt, Keyvan Farahani, Luciana Ferrer, Adrian Galdran, Bram van Ginneken, Ben Glocker, Patrick Godau, Robert Haase, Fred Hamprecht, Daniel A. Hashimoto, Doreen Heckmann-Nötzel, Peter Hirsch, Michael M. Hoffman, Merel Huisman, Fabian Isensee, Pierre Jannin, Charles E. Kahn, Dagmar Kainmueller, Bernhard Kainz, Alexandros Karargyris, Alan Karthikesalingam, A. Emre Kavur, Hannes Kenngott, Jens Kleesiek, Andreas Kleppe, Sven Kohler, Florian Kofler, Annette Kopp-Schneider, Thijs Kooi, Michal Kozubek, Anna Kreshuk, Tahsin Kurc, Bennett A. Landman, Geert Litjens, Amin Madani, Klaus Maier-Hein, Anne L. Martel, Peter Mattson, Erik Meijering, Bjoern Menze, David Moher, Karel G. M. Moons, Henning Müller, Brennan Nichyporuk, Felix Nickel, M. Alican Noyan, Jens Petersen, Gorkem Polat, Susanne M. Rafelski, Nasir Rajpoot, Mauricio Reyes, Nicola Rieke, Michael Riegler, Hassan Rivaz, Julio Saez-Rodriguez, Clara I. Sánchez, Julien Schroeter, Anindo Saha, M. Alper Selver, Lalith Sharan, Shravya Shetty, Maarten van Smeden, Bram Stieltjes, Ronald M. Summers, Abdel A. Taha, Aleksei Tiulpin, Sotirios A. Tsaftaris, Ben van Calster, Gaël Varoquaux, Manuel Wiesenfarth, Ziv R. Yaniv, Paul Jäger, Lena Maier-Hein
While the importance of automatic image analysis is continuously increasing, recent meta-research revealed major flaws with respect to algorithm validation.
no code implementations • 8 Apr 2021 • Abhijit Guha Roy, Jie Ren, Shekoofeh Azizi, Aaron Loh, Vivek Natarajan, Basil Mustafa, Nick Pawlowski, Jan Freyberg, YuAn Liu, Zach Beaver, Nam Vo, Peggy Bui, Samantha Winter, Patricia MacWilliams, Greg S. Corrado, Umesh Telang, Yun Liu, Taylan Cemgil, Alan Karthikesalingam, Balaji Lakshminarayanan, Jim Winkens
We develop and rigorously evaluate a deep learning based system that can accurately classify skin conditions while detecting rare conditions for which there is not enough data available for training a confident classifier.
no code implementations • 14 Jan 2021 • Basil Mustafa, Aaron Loh, Jan Freyberg, Patricia MacWilliams, Megan Wilson, Scott Mayer McKinney, Marcin Sieniek, Jim Winkens, YuAn Liu, Peggy Bui, Shruthi Prabhakara, Umesh Telang, Alan Karthikesalingam, Neil Houlsby, Vivek Natarajan
However, for medical imaging, the value of transfer learning is less clear.
1 code implementation • ICCV 2021 • Shekoofeh Azizi, Basil Mustafa, Fiona Ryan, Zachary Beaver, Jan Freyberg, Jonathan Deaton, Aaron Loh, Alan Karthikesalingam, Simon Kornblith, Ting Chen, Vivek Natarajan, Mohammad Norouzi
Self-supervised pretraining followed by supervised fine-tuning has seen success in image recognition, especially when labeled examples are scarce, but has received limited attention in medical image analysis.
no code implementations • 6 Nov 2020 • Alexander D'Amour, Katherine Heller, Dan Moldovan, Ben Adlam, Babak Alipanahi, Alex Beutel, Christina Chen, Jonathan Deaton, Jacob Eisenstein, Matthew D. Hoffman, Farhad Hormozdiari, Neil Houlsby, Shaobo Hou, Ghassen Jerfel, Alan Karthikesalingam, Mario Lucic, Yian Ma, Cory McLean, Diana Mincu, Akinori Mitani, Andrea Montanari, Zachary Nado, Vivek Natarajan, Christopher Nielson, Thomas F. Osborne, Rajiv Raman, Kim Ramasamy, Rory Sayres, Jessica Schrouff, Martin Seneviratne, Shannon Sequeira, Harini Suresh, Victor Veitch, Max Vladymyrov, Xuezhi Wang, Kellie Webster, Steve Yadlowsky, Taedong Yun, Xiaohua Zhai, D. Sculley
Predictors returned by underspecified pipelines are often treated as equivalent based on their training domain performance, but we show here that such predictors can behave very differently in deployment domains.
no code implementations • 10 Jul 2020 • Jim Winkens, Rudy Bunel, Abhijit Guha Roy, Robert Stanforth, Vivek Natarajan, Joseph R. Ledsam, Patricia MacWilliams, Pushmeet Kohli, Alan Karthikesalingam, Simon Kohl, Taylan Cemgil, S. M. Ali Eslami, Olaf Ronneberger
Reliable detection of out-of-distribution (OOD) inputs is increasingly understood to be a precondition for deployment of machine learning systems.
Ranked #12 on Out-of-Distribution Detection on CIFAR-100 vs CIFAR-10
Out-of-Distribution Detection Out of Distribution (OOD) Detection
2 code implementations • 12 Sep 2018 • Stanislav Nikolov, Sam Blackwell, Alexei Zverovitch, Ruheena Mendes, Michelle Livne, Jeffrey De Fauw, Yojan Patel, Clemens Meyer, Harry Askham, Bernardino Romera-Paredes, Christopher Kelly, Alan Karthikesalingam, Carlton Chu, Dawn Carnell, Cheng Boon, Derek D'Souza, Syed Ali Moinuddin, Bethany Garie, Yasmin McQuinlan, Sarah Ireland, Kiarna Hampton, Krystle Fuller, Hugh Montgomery, Geraint Rees, Mustafa Suleyman, Trevor Back, Cían Hughes, Joseph R. Ledsam, Olaf Ronneberger
We demonstrate the model's clinical applicability by assessing its performance on a test set of 21 CT scans from clinical practice, each with the 21 OARs segmented by two independent experts.