no code implementations • 25 Feb 2025 • Cristina Almagro-Pérez, Andrew H. Song, Luca Weishaupt, Ahrong Kim, Guillaume Jaume, Drew F. K. Williamson, Konstantin Hemker, Ming Y. Lu, Kritika Singh, Bowen Chen, Long Phi Le, Alexander S. Baras, Sizun Jiang, Ali Bashashati, Jonathan T. C. Liu, Faisal Mahmood
A comprehensive three-dimensional (3D) map of tissue architecture and gene expression is crucial for illuminating the complexity and heterogeneity of tissues across diverse biomedical applications.
no code implementations • 10 Sep 2024 • Philip Fradkin, Puria Azadi, Karush Suri, Frederik Wenkel, Ali Bashashati, Maciej Sypetkowski, Dominique Beaini
Predicting molecular impact on cellular function is a core challenge in therapeutic design.
no code implementations • 30 Jul 2024 • Mayur Mallya, Ali Khajegili Mirabadi, Hossein Farahani, Ali Bashashati
Bevacizumab is a widely studied targeted therapeutic drug used in conjunction with standard chemotherapy for the treatment of recurrent ovarian cancer.
no code implementations • 6 Feb 2024 • Ali Khajegili Mirabadi, Graham Archibald, Amirali Darbandsari, Alberto Contreras-Sanz, Ramin Ebrahim Nakhli, Maryam Asadi, Allen Zhang, C. Blake Gilks, Peter Black, Gang Wang, Hossein Farahani, Ali Bashashati
In this work, we present GRASP, a novel lightweight graph-structured multi-magnification framework for processing WSIs in digital pathology.
no code implementations • 8 Mar 2023 • Ramin Nakhli, Allen Zhang, Hossein Farahani, Amirali Darbandsari, Elahe Shenasa, Sidney Thiessen, Katy Milne, Jessica McAlpine, Brad Nelson, C Blake Gilks, Ali Bashashati
To showcase the potential power of our proposed framework, we applied VOLTA to ovarian and endometrial cancers with very small sample sizes (10-20 samples) and demonstrated that our cell representations can be utilized to identify the known histotypes of ovarian cancer and provide novel insights that link histopathology and molecular subtypes of endometrial cancer.
1 code implementation • 1 Mar 2023 • Ramin Nakhli, Puria Azadi Moghadam, Haoyang Mi, Hossein Farahani, Alexander Baras, Blake Gilks, Ali Bashashati
Processing giga-pixel whole slide histopathology images (WSI) is a computationally expensive task.
no code implementations • ICCV 2023 • Ramin Nakhli, Allen Zhang, Ali Mirabadi, Katherine Rich, Maryam Asadi, Blake Gilks, Hossein Farahani, Ali Bashashati
Importantly, our model is able to stratify the patients into different risk cohorts with statistically different outcomes across two large datasets, a task that was previously achievable only using genomic information.
no code implementations • CVPR 2023 • Ramin Nakhli, Puria Azadi Moghadam, Haoyang Mi, Hossein Farahani, Alexander Baras, Blake Gilks, Ali Bashashati
Processing giga-pixel whole slide histopathology images (WSI) is a computationally expensive task.
no code implementations • 17 Dec 2022 • Roozbeh Bazargani, Ladan Fazli, Larry Goldenberg, Martin Gleave, Ali Bashashati, Septimiu Salcudean
In order to leverage the multi-magnification information and early fusion with graph convolutional networks, we handle different embedding spaces at each magnification by introducing the Multi-Scale Relational Graph Convolutional Network (MS-RGCN) as a multiple instance learning method.
no code implementations • 27 Sep 2022 • Puria Azadi Moghadam, Sanne Van Dalen, Karina C. Martin, Jochen Lennerz, Stephen Yip, Hossein Farahani, Ali Bashashati
Recently, diffusion probabilistic models were introduced to generate high quality images.
1 code implementation • 12 Aug 2022 • Ramin Nakhli, Amirali Darbandsari, Hossein Farahani, Ali Bashashati
In this work, we investigated the utility of Self-Supervised Learning (SSL) in cell clustering by proposing the Contrastive Cell Representation Learning (CCRL) model.
1 code implementation • MIDL 2019 • Yiping Wang, David Farnell, Hossein Farahani, Mitchell Nursey, Basile Tessier-Cloutier, Steven J. M. Jones, David G. Huntsman, C. Blake Gilks, Ali Bashashati
The proposed algorithm achieved a mean accuracy of $87. 54\%$ and Cohen's kappa of $0. 8106$ in the slide-level classification of $305$ WSIs; performing better than a standard CNN and pathologists without gynecology-specific training.