On the Value of PHH3 for Mitotic Figure Detection on H&E-stained Images

no code implementations • 28 Jun 2024 • Jonathan Ganz, Christian Marzahl, Jonas Ammeling, Barbara Richter, Chloé Puget, Daniela Denk, Elena A. Demeter, Flaviu A. Tabaran, Gabriel Wasinger, Karoline Lipnik, Marco Tecilla, Matthew J. Valentine, Michael J. Dark, Niklas Abele, Pompei Bolfa, Ramona Erber, Robert Klopfleisch, Sophie Merz, Taryn A. Donovan, Samir Jabari, Christof A. Bertram, Katharina Breininger, Marc Aubreville

Counting MFs on slides stained against PHH3 leads to higher agreement among raters and has therefore recently been used as a ground truth for the annotation of MFs in H&E.

Nuclear Pleomorphism in Canine Cutaneous Mast Cell Tumors: Comparison of Reproducibility and Prognostic Relevance between Estimates, Manual Morphometry and Algorithmic Morphometry

no code implementations • 26 Sep 2023 • Andreas Haghofer, Eda Parlak, Alexander Bartel, Taryn A. Donovan, Charles-Antoine Assenmacher, Pompei Bolfa, Michael J. Dark, Andrea Fuchs-Baumgartinger, Andrea Klang, Kathrin Jäger, Robert Klopfleisch, Sophie Merz, Barbara Richter, F. Yvonne Schulman, Hannah Janout, Jonathan Ganz, Josef Scharinger, Marc Aubreville, Stephan M. Winkler, Matti Kiupel, Christof A. Bertram

We assessed the following nuclear evaluation methods for measurement accuracy, reproducibility, and prognostic utility: 1) anisokaryosis (karyomegaly) estimates by 11 pathologists; 2) gold standard manual morphometry of at least 100 nuclei; 3) practicable manual morphometry with stratified sampling of 12 nuclei by 9 pathologists; and 4) automated morphometry using a deep learning-based segmentation algorithm.

Specificity

Deep Learning-Based Automatic Assessment of AgNOR-scores in Histopathology Images

no code implementations • 15 Dec 2022 • Jonathan Ganz, Karoline Lipnik, Jonas Ammeling, Barbara Richter, Chloé Puget, Eda Parlak, Laura Diehl, Robert Klopfleisch, Taryn A. Donovan, Matti Kiupel, Christof A. Bertram, Katharina Breininger, Marc Aubreville

Nucleolar organizer regions (NORs) are parts of the DNA that are involved in RNA transcription.