Seizure freedom after surgical resection of diffusion-weighted MRI abnormalities

no code implementations • 4 Oct 2024 • Jonathan Horsley, Gerard Hall, Callum Simpson, Csaba Kozma, Rhys Thomas, Yujiang Wang, Jane de Tisi, Anna Miserocchi, Andrew McEvoy, Sjoerd Vos, Gavin Winston, John Duncan, Peter Taylor

Current clinical approaches to identify structural abnormalities for surgical targeting in epilepsy do not use diffusion-weighted MRI (dMRI), despite evidence that dMRI abnormalities are present in epilepsy and may relate to the epileptogenic zone.

Status epilepticus and thinning of the entorhinal cortex

no code implementations • 11 Aug 2024 • Jonathan Horsley, Yujiang Wang, Callum Simpson, Vyte Janiukstyte, Karoline Leiberg, Beth Little, Jane de Tisi, John Duncan, Peter N. Taylor

Individuals with TLE and SE had reduced entorhinal thickness compared to those with TLE and no history of SE.

The Imaging Database for Epilepsy And Surgery (IDEAS)

no code implementations • 10 Jun 2024 • Peter N. Taylor, Yujiang Wang, Callum Simpson, Vytene Janiukstyte, Jonathan Horsley, Karoline Leiberg, Beth Little, Harry Clifford, Sophie Adler, Sjoerd B. Vos, Gavin P Winston, Andrew W McEvoy, Anna Miserocchi, Jane de Tisi, John S Duncan

To demonstrate the veracity of our data, we successfully replicated previous studies showing long-term outcomes of seizure freedom in the range of around 50%.

Lesion Detection Surface Reconstruction

Multi-centre normative brain mapping of intracranial EEG lifespan patterns in the human brain

no code implementations • 27 Apr 2024 • Heather Woodhouse, Gerard Hall, Callum Simpson, Csaba Kozma, Frances Turner, Gabrielle M. Schroeder, Beate Diehl, John S. Duncan, Jiajie Mo, Kai Zhang, Aswin Chari, Martin Tisdall, Friederike Moeller, Chris Petkov, Matthew A. Howard, George M. Ibrahim, Elizabeth Donner, Nebras M. Warsi, Raheel Ahmed, Peter N. Taylor, Yujiang Wang

Results: Recording hospital significantly impacted normative icEEG maps in all frequency bands, and age was a more influential predictor of band power than sex.

EEG

Incomplete resection of the icEEG seizure onset zone is not associated with post-surgical outcomes

no code implementations • 24 Nov 2023 • Sarah J. Gascoigne, Nathan Evans, Gerard Hall, Csaba Kozma, Mariella Panagiotopoulou, Gabrielle M. Schroeder, Callum Simpson, Christopher Thornton, Frances Turner, Heather Woodhouse, Jess Blickwedel, Fahmida Chowdhury, Beate Diehl, John S. Duncan, Ryan Faulder, Rhys H. Thomas, Kevin Wilson, Peter N. Taylor, Yujiang Wang

Retrospective analysis of icEEG recordings from 63 subjects (735 seizures) identified seizure onset regions through visual inspection and algorithmic delineation.

EEG