1 code implementation • 27 Jul 2024 • Bailiang Jian, Jiazhen Pan, Morteza Ghahremani, Daniel Rueckert, Christian Wachinger, Benedikt Wiestler
Our findings indicate that adopting "advanced" computational elements fails to significantly improve registration accuracy.
1 code implementation • 4 Jun 2024 • Jiajun Wang, Morteza Ghahremani, Yitong Li, Björn Ommer, Christian Wachinger
Controllable text-to-image (T2I) diffusion models have shown impressive performance in generating high-quality visual content through the incorporation of various conditions.
1 code implementation • 27 May 2024 • Yitong Li, Igor Yakushev, Dennis M. Hedderich, Christian Wachinger
Our qualitative and quantitative results confirm that the synthesized PET scans from PASTA not only reach the best quantitative scores but also preserve the pathology correctly.
1 code implementation • 9 Apr 2024 • Yitong Li, Tom Nuno Wolf, Sebastian Pölsterl, Igor Yakushev, Dennis M. Hedderich, Christian Wachinger
To address these issues, we propose Triplet Training for differential diagnosis with limited target data.
no code implementations • 11 Mar 2024 • Christian Wachinger, Dennis Hedderich, Fabian Bongratz
Magnetic resonance imaging (MRI) is critical for diagnosing neurodegenerative diseases, yet accurately assessing mild cortical atrophy remains a challenge due to its subtlety.
no code implementations • 27 Feb 2024 • Fabian Bongratz, Jan Fecht, Anne-Marie Rickmann, Christian Wachinger
In contrast to existing methods, V2C-Long surfaces are directly comparable in a cross-sectional and longitudinal manner.
1 code implementation • 23 Jan 2024 • Fabian Bongratz, Anne-Marie Rickmann, Christian Wachinger
The reconstruction of cortical surfaces is a prerequisite for quantitative analyses of the cerebral cortex in magnetic resonance imaging (MRI).
1 code implementation • CVPR 2024 • Morteza Ghahremani, Mohammad Khateri, Bailiang Jian, Benedikt Wiestler, Ehsan Adeli, Christian Wachinger
This paper introduces a novel top-down representation approach for deformable image registration which estimates the deformation field by capturing various short- and long-range flow features at different scale levels.
1 code implementation • 15 Dec 2023 • Tom Nuno Wolf, Fabian Bongratz, Anne-Marie Rickmann, Sebastian Pölsterl, Christian Wachinger
During inference, similarities of latent features to prototypes are linearly classified to form predictions and attribution maps are provided to explain the similarity.
1 code implementation • NeurIPS 2023 • Morteza Ghahremani, Christian Wachinger
The proposed method demonstrates broad applicability across different architectures such as multilayer perceptrons, convolutional neural networks, and vision transformers, enabling effective normalization of both low- and high-level features in multimodal neural networks.
1 code implementation • 30 Aug 2023 • Jianning Li, Zongwei Zhou, Jiancheng Yang, Antonio Pepe, Christina Gsaxner, Gijs Luijten, Chongyu Qu, Tiezheng Zhang, Xiaoxi Chen, Wenxuan Li, Marek Wodzinski, Paul Friedrich, Kangxian Xie, Yuan Jin, Narmada Ambigapathy, Enrico Nasca, Naida Solak, Gian Marco Melito, Viet Duc Vu, Afaque R. Memon, Christopher Schlachta, Sandrine de Ribaupierre, Rajnikant Patel, Roy Eagleson, Xiaojun Chen, Heinrich Mächler, Jan Stefan Kirschke, Ezequiel de la Rosa, Patrick Ferdinand Christ, Hongwei Bran Li, David G. Ellis, Michele R. Aizenberg, Sergios Gatidis, Thomas Küstner, Nadya Shusharina, Nicholas Heller, Vincent Andrearczyk, Adrien Depeursinge, Mathieu Hatt, Anjany Sekuboyina, Maximilian Löffler, Hans Liebl, Reuben Dorent, Tom Vercauteren, Jonathan Shapey, Aaron Kujawa, Stefan Cornelissen, Patrick Langenhuizen, Achraf Ben-Hamadou, Ahmed Rekik, Sergi Pujades, Edmond Boyer, Federico Bolelli, Costantino Grana, Luca Lumetti, Hamidreza Salehi, Jun Ma, Yao Zhang, Ramtin Gharleghi, Susann Beier, Arcot Sowmya, Eduardo A. Garza-Villarreal, Thania Balducci, Diego Angeles-Valdez, Roberto Souza, Leticia Rittner, Richard Frayne, Yuanfeng Ji, Vincenzo Ferrari, Soumick Chatterjee, Florian Dubost, Stefanie Schreiber, Hendrik Mattern, Oliver Speck, Daniel Haehn, Christoph John, Andreas Nürnberger, João Pedrosa, Carlos Ferreira, Guilherme Aresta, António Cunha, Aurélio Campilho, Yannick Suter, Jose Garcia, Alain Lalande, Vicky Vandenbossche, Aline Van Oevelen, Kate Duquesne, Hamza Mekhzoum, Jef Vandemeulebroucke, Emmanuel Audenaert, Claudia Krebs, Timo Van Leeuwen, Evie Vereecke, Hauke Heidemeyer, Rainer Röhrig, Frank Hölzle, Vahid Badeli, Kathrin Krieger, Matthias Gunzer, Jianxu Chen, Timo van Meegdenburg, Amin Dada, Miriam Balzer, Jana Fragemann, Frederic Jonske, Moritz Rempe, Stanislav Malorodov, Fin H. Bahnsen, Constantin Seibold, Alexander Jaus, Zdravko Marinov, Paul F. Jaeger, Rainer Stiefelhagen, Ana Sofia Santos, Mariana Lindo, André Ferreira, Victor Alves, Michael Kamp, Amr Abourayya, Felix Nensa, Fabian Hörst, Alexander Brehmer, Lukas Heine, Yannik Hanusrichter, Martin Weßling, Marcel Dudda, Lars E. Podleska, Matthias A. Fink, Julius Keyl, Konstantinos Tserpes, Moon-Sung Kim, Shireen Elhabian, Hans Lamecker, Dženan Zukić, Beatriz Paniagua, Christian Wachinger, Martin Urschler, Luc Duong, Jakob Wasserthal, Peter F. Hoyer, Oliver Basu, Thomas Maal, Max J. H. Witjes, Gregor Schiele, Ti-chiun Chang, Seyed-Ahmad Ahmadi, Ping Luo, Bjoern Menze, Mauricio Reyes, Thomas M. Deserno, Christos Davatzikos, Behrus Puladi, Pascal Fua, Alan L. Yuille, Jens Kleesiek, Jan Egger
For the medical domain, we present a large collection of anatomical shapes (e. g., bones, organs, vessels) and 3D models of surgical instrument, called MedShapeNet, created to facilitate the translation of data-driven vision algorithms to medical applications and to adapt SOTA vision algorithms to medical problems.
1 code implementation • 27 Jun 2023 • Fabian Bongratz, Anne-Marie Rickmann, Christian Wachinger
However, the generalization of these deep learning-based approaches to different organs and datasets, a crucial property for deployment in clinical environments, has not yet been assessed.
1 code implementation • 14 Mar 2023 • Anne-Marie Rickmann, Murong Xu, Tom Nuno Wolf, Oksana Kovalenko, Christian Wachinger
The wide range of research in deep learning-based medical image segmentation pushed the boundaries in a multitude of applications.
1 code implementation • 13 Mar 2023 • Tom Nuno Wolf, Sebastian Pölsterl, Christian Wachinger
We propose PANIC, a prototypical additive neural network for interpretable AD classification that integrates 3D image and tabular data.
no code implementations • 19 Sep 2022 • Anne-Marie Rickmann, Fabian Bongratz, Sebastian Pölsterl, Ignacio Sarasua, Christian Wachinger
The reconstruction of cerebral cortex surfaces from brain MRI scans is instrumental for the analysis of brain morphology and the detection of cortical thinning in neurodegenerative diseases like Alzheimer's disease (AD).
no code implementations • 5 Jul 2022 • Ignacio Sarasua, Sebastian Pölsterl, Christian Wachinger
To this end, we introduce CASHformer, a transformer-based framework to model longitudinal shape trajectories in AD.
no code implementations • 5 Jul 2022 • Marla Narazani, Ignacio Sarasua, Sebastian Pölsterl, Aldana Lizarraga, Igor Yakushev, Christian Wachinger
AD classification and focus on differential diagnosis of dementia, where fusing multi-modal image information conforms with a clinical need.
1 code implementation • CVPR 2022 • Fabian Bongratz, Anne-Marie Rickmann, Sebastian Pölsterl, Christian Wachinger
The reconstruction of cortical surfaces from brain magnetic resonance imaging (MRI) scans is essential for quantitative analyses of cortical thickness and sulcal morphology.
no code implementations • 1 Sep 2021 • Ignacio Sarasua, Sebastian Pölsterl, Christian Wachinger
To the best of our knowledge, this is the first work that combines transformer and mesh networks.
no code implementations • 12 Aug 2021 • Raphael Ronge, Kwangsik Nho, Christian Wachinger, Sebastian Pölsterl
The current state-of-the-art deep neural networks (DNNs) for Alzheimer's Disease diagnosis use different biomarker combinations to classify patients, but do not allow extracting knowledge about the interactions of biomarkers.
1 code implementation • 13 Jul 2021 • Sebastian Pölsterl, Christina Aigner, Christian Wachinger
We propose Shapley Value Explanation of Heterogeneous Neural Networks (SVEHNN) for explaining the Alzheimer's diagnosis made by a DNN from the 3D point cloud of the neuroanatomy and tabular biomarkers.
2 code implementations • 13 Jul 2021 • Sebastian Pölsterl, Tom Nuno Wolf, Christian Wachinger
Prior work on diagnosing Alzheimer's disease from magnetic resonance images of the brain established that convolutional neural networks (CNNs) can leverage the high-dimensional image information for classifying patients.
1 code implementation • 10 Jun 2021 • Michela Antonelli, Annika Reinke, Spyridon Bakas, Keyvan Farahani, AnnetteKopp-Schneider, Bennett A. Landman, Geert Litjens, Bjoern Menze, Olaf Ronneberger, Ronald M. Summers, Bram van Ginneken, Michel Bilello, Patrick Bilic, Patrick F. Christ, Richard K. G. Do, Marc J. Gollub, Stephan H. Heckers, William R. Jarnagin, Maureen K. McHugo, Sandy Napel, Jennifer S. Goli Pernicka, Kawal Rhode, Catalina Tobon-Gomez, Eugene Vorontsov, Henkjan Huisman, James A. Meakin, Sebastien Ourselin, Manuel Wiesenfarth, Pablo Arbelaez, Byeonguk Bae, Sihong Chen, Laura Daza, Jianjiang Feng, Baochun He, Fabian Isensee, Yuanfeng Ji, Fucang Jia, Namkug Kim, Ildoo Kim, Dorit Merhof, Akshay Pai, Beomhee Park, Mathias Perslev, Ramin Rezaiifar, Oliver Rippel, Ignacio Sarasua, Wei Shen, Jaemin Son, Christian Wachinger, Liansheng Wang, Yan Wang, Yingda Xia, Daguang Xu, Zhanwei Xu, Yefeng Zheng, Amber L. Simpson, Lena Maier-Hein, M. Jorge Cardoso
Segmentation is so far the most widely investigated medical image processing task, but the various segmentation challenges have typically been organized in isolation, such that algorithm development was driven by the need to tackle a single specific clinical problem.
no code implementations • 23 Apr 2021 • Fabian Gröger, Anne-Marie Rickmann, Christian Wachinger
We propose to predict the uncertainty of pseudo labels and integrate it in the training process with an uncertainty-guided loss function to highlight labels with high certainty.
no code implementations • 20 Apr 2021 • Ignacio Sarasua, Jonwong Lee, Christian Wachinger
Geometric deep learning can find representations that are optimal for a given task and therefore improve the performance over pre-defined representations.
no code implementations • 25 Nov 2020 • Ignacio Sarasua, Sebastian Poelsterl, Christian Wachinger
First, we demonstrate the benefit and versatility of our proposed modules by incorporating them into three state-of-the-art networks for 3D point cloud analysis: PointNet++, DGCNN, and RSCNN.
no code implementations • 11 Nov 2020 • Philipp Kopper, Sebastian Pölsterl, Christian Wachinger, Bernd Bischl, Andreas Bender, David Rügamer
We propose a versatile framework for survival analysis that combines advanced concepts from statistics with deep learning.
no code implementations • 2 Oct 2020 • Benjamin Gutierrez Becker, Ignacio Sarasua, Christian Wachinger
The key insights are that (i) learning a shape representation specific to the given task yields higher performance than alternative shape descriptors, (ii) multi-structure analysis is both more efficient and more accurate than single-structure analysis, and (iii) point clouds generated by our model capture morphological differences associated to Alzheimers disease, to the point that they can be used to train a discriminative model for disease classification.
1 code implementation • 23 Jun 2020 • Sebastian Pölsterl, Christian Wachinger
We derive a causal graph from the current clinical knowledge on cause and effect in the Alzheimer's disease continuum, and show that identifiability of the causal effect requires all confounders to be known and measured.
2 code implementations • 30 Apr 2020 • Sinan Özgür Özgün, Anne-Marie Rickmann, Abhijit Guha Roy, Christian Wachinger
The ability of neural networks to continuously learn and adapt to new tasks while retaining prior knowledge is crucial for many applications.
1 code implementation • 25 Feb 2020 • Anne-Marie Rickmann, Abhijit Guha Roy, Ignacio Sarasua, Christian Wachinger
Fully Convolutional Neural Networks (F-CNNs) achieve state-of-the-art performance for segmentation tasks in computer vision and medical imaging.
1 code implementation • 12 Feb 2020 • Christian Wachinger, Anna Rieckmann, Sebastian Pölsterl
Given such evidence, we take a closer look at confounding bias, which is often viewed as the main shortcoming in observational studies.
no code implementations • 9 Sep 2019 • Sebastian Pölsterl, Ignacio Sarasua, Benjamín Gutiérrez-Becker, Christian Wachinger
Our network is trained end-to-end to combine information from a patient's hippocampus shape and clinical biomarkers.
no code implementations • 9 Jul 2019 • Christian Wachinger, Benjamin Gutierrez Becker, Anna Rieckmann, Sebastian Pölsterl
In this work, we combine 12, 207 MRI scans from 15 studies and show that simple pooling is often ill-advised due to introducing various types of biases in the training data.
2 code implementations • 11 Jun 2019 • Anne-Marie Rickmann, Abhijit Guha Roy, Ignacio Sarasua, Nassir Navab, Christian Wachinger
Fully Convolutional Neural Networks (F-CNNs) achieve state-of-the-art performance for image segmentation in medical imaging.
1 code implementation • 24 May 2019 • Sebastian Pölsterl, Christian Wachinger
Recent methods for generating novel molecules use graph representations of molecules and employ various forms of graph convolutional neural networks for inference.
no code implementations • 16 May 2019 • Abhijit Guha Roy, Shayan Siddiqui, Sebastian Pölsterl, Nassir Navab, Christian Wachinger
A disadvantage of FL is the dependence on a central server, which requires all clients to agree on one trusted central body, and whose failure would disrupt the training process of all clients.
2 code implementations • 4 Feb 2019 • Abhijit Guha Roy, Shayan Siddiqui, Sebastian Pölsterl, Nassir Navab, Christian Wachinger
This representation is passed on to the segmenter arm that uses this information to segment the new query image.
no code implementations • 14 Jan 2019 • Magdalini Paschali, Walter Simson, Abhijit Guha Roy, Muhammad Ferjad Naeem, Rüdiger Göbl, Christian Wachinger, Nassir Navab
Compared with traditional augmentation methods, and with images synthesized by Generative Adversarial Networks our method not only achieves state-of-the-art performance but also significantly improves the network's robustness.
6 code implementations • 13 Jan 2019 • Patrick Bilic, Patrick Christ, Hongwei Bran Li, Eugene Vorontsov, Avi Ben-Cohen, Georgios Kaissis, Adi Szeskin, Colin Jacobs, Gabriel Efrain Humpire Mamani, Gabriel Chartrand, Fabian Lohöfer, Julian Walter Holch, Wieland Sommer, Felix Hofmann, Alexandre Hostettler, Naama Lev-Cohain, Michal Drozdzal, Michal Marianne Amitai, Refael Vivantik, Jacob Sosna, Ivan Ezhov, Anjany Sekuboyina, Fernando Navarro, Florian Kofler, Johannes C. Paetzold, Suprosanna Shit, Xiaobin Hu, Jana Lipková, Markus Rempfler, Marie Piraud, Jan Kirschke, Benedikt Wiestler, Zhiheng Zhang, Christian Hülsemeyer, Marcel Beetz, Florian Ettlinger, Michela Antonelli, Woong Bae, Míriam Bellver, Lei Bi, Hao Chen, Grzegorz Chlebus, Erik B. Dam, Qi Dou, Chi-Wing Fu, Bogdan Georgescu, Xavier Giró-i-Nieto, Felix Gruen, Xu Han, Pheng-Ann Heng, Jürgen Hesser, Jan Hendrik Moltz, Christian Igel, Fabian Isensee, Paul Jäger, Fucang Jia, Krishna Chaitanya Kaluva, Mahendra Khened, Ildoo Kim, Jae-Hun Kim, Sungwoong Kim, Simon Kohl, Tomasz Konopczynski, Avinash Kori, Ganapathy Krishnamurthi, Fan Li, Hongchao Li, Junbo Li, Xiaomeng Li, John Lowengrub, Jun Ma, Klaus Maier-Hein, Kevis-Kokitsi Maninis, Hans Meine, Dorit Merhof, Akshay Pai, Mathias Perslev, Jens Petersen, Jordi Pont-Tuset, Jin Qi, Xiaojuan Qi, Oliver Rippel, Karsten Roth, Ignacio Sarasua, Andrea Schenk, Zengming Shen, Jordi Torres, Christian Wachinger, Chunliang Wang, Leon Weninger, Jianrong Wu, Daguang Xu, Xiaoping Yang, Simon Chun-Ho Yu, Yading Yuan, Miao Yu, Liping Zhang, Jorge Cardoso, Spyridon Bakas, Rickmer Braren, Volker Heinemann, Christopher Pal, An Tang, Samuel Kadoury, Luc Soler, Bram van Ginneken, Hayit Greenspan, Leo Joskowicz, Bjoern Menze
In this work, we report the set-up and results of the Liver Tumor Segmentation Benchmark (LiTS), which was organized in conjunction with the IEEE International Symposium on Biomedical Imaging (ISBI) 2017 and the International Conferences on Medical Image Computing and Computer-Assisted Intervention (MICCAI) 2017 and 2018.
2 code implementations • 24 Nov 2018 • Abhijit Guha Roy, Sailesh Conjeti, Nassir Navab, Christian Wachinger
Next to voxel-wise uncertainty, we introduce four metrics to quantify structure-wise uncertainty in segmentation for quality control.
no code implementations • 11 Oct 2018 • Shubham Kumar, Sailesh Conjeti, Abhijit Guha Roy, Christian Wachinger, Nassir Navab
We present a novel, parameter-efficient and practical fully convolutional neural network architecture, termed InfiNet, aimed at voxel-wise semantic segmentation of infant brain MRI images at iso-intense stage, which can be easily extended for other segmentation tasks involving multi-modalities.
5 code implementations • 23 Aug 2018 • Abhijit Guha Roy, Nassir Navab, Christian Wachinger
Towards this end, we introduce three variants of SE modules for segmentation, (i) squeezing spatially and exciting channel-wise, (ii) squeezing channel-wise and exciting spatially and (iii) joint spatial and channel 'squeeze & excitation'.
no code implementations • 6 Aug 2018 • Benjamin Gutierrez-Becker, Sergios Gatidis, Daniel Gutmann, Annette Peters, Christopher Schlett Fabian Bamberg, Christian Wachinger
Morphological analysis of organs based on images is a key task in medical imaging computing.
no code implementations • 22 Jun 2018 • Christian Wachinger, Matthew Toews, Georg Langs, William Wells, Polina Golland
We introduce an approach for image segmentation based on sparse correspondences between keypoints in testing and training images.
no code implementations • 4 Jun 2018 • Benjamin Gutierrez-Becker, Christian Wachinger
We propose a deep neural network for supervised learning on neuroanatomical shapes.
no code implementations • 28 Apr 2018 • Christian Wachinger, Benjamin Gutierrez Becker, Anna Rieckmann
Next, we introduce metrics to quantify the compatibility across datasets and to create embeddings of neuroimaging sites.
no code implementations • 19 Apr 2018 • Abhijit Guha Roy, Sailesh Conjeti, Nassir Navab, Christian Wachinger
We introduce inherent measures for effective quality control of brain segmentation based on a Bayesian fully convolutional neural network, using model uncertainty.
no code implementations • 4 Apr 2018 • Benjamin Gutierrez Becker, Tassilo Klein, Christian Wachinger
Finally, we illustrate differences in the disease pattern to normal aging, supporting the application of uncertainty as a measure of neuropathology.
10 code implementations • 7 Mar 2018 • Abhijit Guha Roy, Nassir Navab, Christian Wachinger
Fully convolutional neural networks (F-CNNs) have set the state-of-the-art in image segmentation for a plethora of applications.
6 code implementations • 12 Jan 2018 • Abhijit Guha Roy, Sailesh Conjeti, Nassir Navab, Christian Wachinger
We introduce QuickNAT, a fully convolutional, densely connected neural network that segments a \revision{MRI brain scan} in 20 seconds.
no code implementations • 23 May 2017 • Benjamín Gutiérrez, Loïc Peter, Tassilo Klein, Christian Wachinger
With the availability of big medical image data, the selection of an adequate training set is becoming more important to address the heterogeneity of different datasets.
no code implementations • 2 May 2017 • Abhijit Guha Roy, Sailesh Conjeti, Debdoot Sheet, Amin Katouzian, Nassir Navab, Christian Wachinger
While large datasets of unlabeled image data are available in medical applications, access to manually labeled data is very limited.
2 code implementations • 7 Apr 2017 • Abhijit Guha Roy, Sailesh Conjeti, Sri Phani Krishna Karri, Debdoot Sheet, Amin Katouzian, Christian Wachinger, Nassir Navab
Optical coherence tomography (OCT) is used for non-invasive diagnosis of diabetic macular edema assessing the retinal layers.
no code implementations • 27 Feb 2017 • Christian Wachinger, Martin Reuter, Tassilo Klein
We introduce DeepNAT, a 3D Deep convolutional neural network for the automatic segmentation of NeuroAnaTomy in T1-weighted magnetic resonance images.
no code implementations • 11 Mar 2015 • Christian Wachinger, Polina Golland
High computational costs of manifold learning prohibit its application for large point sets.
no code implementations • 22 Mar 2013 • George H. Chen, Christian Wachinger, Polina Golland
To this end, out-of-sample extensions are applied by constructing an interpolation function that maps from the input space to the low-dimensional manifold.