Seizure freedom after surgical resection of diffusion-weighted MRI abnormalities

no code implementations • 4 Oct 2024 • Jonathan Horsley, Gerard Hall, Callum Simpson, Csaba Kozma, Rhys Thomas, Yujiang Wang, Jane de Tisi, Anna Miserocchi, Andrew McEvoy, Sjoerd Vos, Gavin Winston, John Duncan, Peter Taylor

Current clinical approaches to identify structural abnormalities for surgical targeting in epilepsy do not use diffusion-weighted MRI (dMRI), despite evidence that dMRI abnormalities are present in epilepsy and may relate to the epileptogenic zone.

Multi-centre normative brain mapping of intracranial EEG lifespan patterns in the human brain

no code implementations • 27 Apr 2024 • Heather Woodhouse, Gerard Hall, Callum Simpson, Csaba Kozma, Frances Turner, Gabrielle M. Schroeder, Beate Diehl, John S. Duncan, Jiajie Mo, Kai Zhang, Aswin Chari, Martin Tisdall, Friederike Moeller, Chris Petkov, Matthew A. Howard, George M. Ibrahim, Elizabeth Donner, Nebras M. Warsi, Raheel Ahmed, Peter N. Taylor, Yujiang Wang

Results: Recording hospital significantly impacted normative icEEG maps in all frequency bands, and age was a more influential predictor of band power than sex.

EEG

Alpha rhythm slowing in temporal epilepsy across Scalp EEG and MEG

no code implementations • 16 Apr 2024 • Vytene Janiukstyte, Csaba Kozma, Thomas W. Owen, Umair J Chaudhury, Beate Diehl, Louis Lemieux, John S Duncan, Fergus Rugg-Gunn, Jane de Tisi, Yujiang Wang, Peter N. Taylor

Alpha slowing in TLE was found in both EEG and MEG recordings.

EEG

Incomplete resection of the icEEG seizure onset zone is not associated with post-surgical outcomes

no code implementations • 24 Nov 2023 • Sarah J. Gascoigne, Nathan Evans, Gerard Hall, Csaba Kozma, Mariella Panagiotopoulou, Gabrielle M. Schroeder, Callum Simpson, Christopher Thornton, Frances Turner, Heather Woodhouse, Jess Blickwedel, Fahmida Chowdhury, Beate Diehl, John S. Duncan, Ryan Faulder, Rhys H. Thomas, Kevin Wilson, Peter N. Taylor, Yujiang Wang

Retrospective analysis of icEEG recordings from 63 subjects (735 seizures) identified seizure onset regions through visual inspection and algorithmic delineation.

EEG

Aperiodic MEG abnormality in patients with focal to bilateral tonic-clonic seizures

no code implementations • 18 Oct 2023 • Kirandeep Kaur, Jonathan J Horsley, Csaba Kozma, Gerard R Hall, Thomas W Owen, Yujiang Wang, Guarav Singh, Sarat P Chandra, Manjari Tripathi, Peter N Taylor

Here, we hypothesised greater aperiodic abnormality in the epileptogenic zone, in patients with focal to bilateral tonic clonic (FBTC) seizures, and earlier age of seizure onset.

Identifying epileptogenic abnormality by decomposing intracranial EEG and MEG power spectra

no code implementations • 10 Oct 2023 • Csaba Kozma, Gabrielle Schroeder, Tom Owen, Jane de Tisi, Andrew W. McEvoy, Anna Miserocchi, John Duncan, Yujiang Wang, Peter N. Taylor

Combining periodic and aperiodic abnormalities improved performance, similar to the complete band power approach.

EEG