Brain age identification from diffusion MRI synergistically predicts neurodegenerative disease

1 code implementation • 29 Oct 2024 • Chenyu Gao, Michael E. Kim, Karthik Ramadass, Praitayini Kanakaraj, Aravind R. Krishnan, Adam M. Saunders, Nancy R. Newlin, Ho Hin Lee, Qi Yang, Warren D. Taylor, Brian D. Boyd, Lori L. Beason-Held, Susan M. Resnick, Lisa L. Barnes, David A. Bennett, Katherine D. Van Schaik, Derek B. Archer, Timothy J. Hohman, Angela L. Jefferson, Ivana Išgum, Daniel Moyer, Yuankai Huo, Kurt G. Schilling, Lianrui Zuo, Shunxing Bao, Nazirah Mohd Khairi, Zhiyuan Li, Christos Davatzikos, Bennett A. Landman

We observe difference between our dMRI-based brain age and T1w MRI-based brain age across stages of neurodegeneration, with dMRI-based brain age being older than T1w MRI-based brain age in participants transitioning from cognitively normal (CN) to mild cognitive impairment (MCI), but younger in participants already diagnosed with Alzheimer's disease (AD).

Age Estimation Diffusion MRI +1