no code implementations • 19 Apr 2021 • Elisabeth G. Rens, Leah Edelstein-Keshet
The small GTPases Rac and Rho are known to regulate eukaryotic cell shape, promoting front protrusion (Rac) or rear retraction (Rho) of the cell edge.
no code implementations • 23 Sep 2019 • Yue Liu, Elisabeth G. Rens, Leah Edelstein-Keshet
The polarization and motility of eukaryotic cells depends on assembly and contraction of the actin cytoskeleton and its regulation by proteins called GTPases.
no code implementations • 21 Jun 2019 • Elisabeth G. Rens, Roeland M. H. Merks
Many animal cells change their shape depending on the stiffness of the substrate on which they are cultured: they assume small, rounded shapes in soft ECMs, they elongate within stiffer ECMs, and flatten out on hard substrates.