We use Direct Coupling Analysis (DCA) to determine epistatic interactions between loci of variability of the SARS-CoV-2 virus, segmenting genomes by month of sampling.
We compute the allele frequencies of the alpha (B. 1. 1. 7), beta (B. 1. 351) and delta (B. 167. 2) variants of SARS-CoV-2 from almost two million genome sequences on the GISAID repository.
Our goals here are to clarify under which conditions the QLE phase can be expected to hold in population biology and how the stability of the QLE phase is lost.
Our no-go theorem implies that any time symmetric formulation of quantum theory must either restrict the set of the allowed evolutions, or modify the operational interpretation of quantum states and processes.
Quantum Physics Mathematical Physics Mathematical Physics
In contrast, the single-mode thermality of Hawking radiation originating from microscopic black holes, expected to evaporate through several quanta, is not excluded, though there are constraints on modes' frequencies.
Information Retrieval General Relativity and Quantum Cosmology High Energy Physics - Theory Quantum Physics 83C57, 81P45, 81V80
We consider a population evolving due to mutation, selection and recombination, where selection includes single-locus terms (additive fitness) and two-loci terms (pairwise epistatic fitness).
Correlation patterns in multiple sequence alignments of homologous proteins can be exploited to infer information on the three-dimensional structure of their members.
Direct-Coupling Analysis is a group of methods to harvest information about coevolving residues in a protein family by learning a generative model in an exponential family from data.