no code implementations • 16 Apr 2019 • Dongya Jia, Xuefei Li, Federico Bocci, Shubham Tripathi, Youyuan Deng, Mohit Kumar Jolly, Jose N. Onuchic, Herbert Levine
In this review, we first discuss recent efforts combining theoretical and experimental approaches to elucidate mechanisms underlying EMT multi-stability (i. e. the existence of multiple stable phenotypes during EMT) and the properties of hybrid E/M phenotypes.
no code implementations • 12 May 2020 • Federico Bocci, Jose Nelson Onuchic, Mohit Kumar Jolly
Notch signaling is an evolutionary conserved cell-cell communication pathway.
no code implementations • 1 Feb 2022 • Madeline Galbraith, Federico Bocci, José N. Onuchic
The Notch-Delta signaling pathway mediates cell differentiation implicated in many regulatory processes including spatiotemporal patterning in tissues by promoting alternate cell fates between neighboring cells.
1 code implementation • 14 Feb 2023 • Federico Bocci, Dongya Jia, Qing Nie, Mohit Kumar Jolly, Jose Onuchic
The last decade has witnessed a surge of theoretical and computational models to describe the dynamics of complex gene regulatory networks, and how these interactions can give rise to multistable and heterogeneous cell populations.