Here we present an embedding of natural protein sequences using a Variational Auto-Encoder and use it to predict how mutations affect protein function.
Current high-resolution imaging techniques require an intact sample that preserves spatial relationships.
no code implementations • 21 Apr 2014 • Adam H. Marblestone, Evan R Daugharthy, Reza Kalhor, Ian D Peikon, Justus M Kebschull, Seth L Shipman, Yuriy Mishchenko, Je Hyuk Lee, Konrad P. Kording, Edward S. Boyden, Anthony M Zador, George M. Church
We propose a neural connectomics strategy called Fluorescent In-Situ Sequencing of Barcoded Individual Neuronal Connections (FISSEQ-BOINC), leveraging fluorescent in situ nucleic acid sequencing in fixed tissue (FISSEQ).
Neurons and Cognition
no code implementations • 24 Jun 2013 • Adam H. Marblestone, Bradley M. Zamft, Yael G. Maguire, Mikhail G. Shapiro, Thaddeus R. Cybulski, Joshua I. Glaser, Dario Amodei, P. Benjamin Stranges, Reza Kalhor, David A. Dalrymple, Dongjin Seo, Elad Alon, Michel M. Maharbiz, Jose M. Carmena, Jan M. Rabaey, Edward S. Boyden, George M. Church, Konrad P. Kording
Simultaneously measuring the activities of all neurons in a mammalian brain at millisecond resolution is a challenge beyond the limits of existing techniques in neuroscience.
Neurons and Cognition Biological Physics