SANA: Cross-Species Prediction of Gene Ontology GO Annotations via Topological Network Alignment

1 code implementation • 26 Apr 2022 • Siyue Wang, Giles R. S. Atkinson, Wayne B. Hayes

We argue that this failure of topology alone is due to the sparsity and incompleteness of the PPI network data of almost all species, which provides the network topology with a small signal-to-noise ratio that is effectively swamped when sequence information is added to the mix.

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