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Photodynamic, UV-curable and fibre-forming polyvinyl alcohol derivative with broad processability and staining-free antibacterial capability
To address these challenges, we present the design of a bespoke polyvinyl alcohol (PVA) derivative conjugated with both phenothiazine and methacrylate functionalities, enabling staining-free antibacterial photodynamic effects, cellular tolerability and processability into various wound dressing formats, including films, textile fibres and nanoscale coatings.
Mechanical and suture-holding properties of a UV-cured atelocollagen membrane with varied crosslinked architecture
The mechanical competence and suturing ability of collagen-based membranes are paramount in Guided Bone Regeneration (GBR) therapy, to ensure damage-free implantation, fixation and space maintenance in vivo.
Nonwoven Reinforced Photocurable Poly(glycerol sebacate)-Based Hydrogels
The nonwoven reinforced PGSLPA hydrogels exhibited a 60 % increase in compressive strength and an 80 % increase in elastic moduli compared to fibre-free PGSLPA samples.
Infection-responsivity of Commercial Dressings Through Halochromic Drop-casting
Infection control remains one of the most challenging tasks in wound care, due to growing antimicrobial resistance and ineffective infection diagnostic tools at the point-of-care.
A photo-click thiol-ene collagen-based hydrogel platform for skeletal muscle tissue engineering
UV-cured collagen-based hydrogels hold promise in skeletal muscle regeneration due to their soft elastic properties and porous architecture.
A collagen-based theranostic wound dressing with visual, long-lasting infection detection capability
Continuous wound monitoring is one strategy to minimise infection severity and inform prompt variations in therapeutic care following infection diagnosis.
Effect of Mammalian Tissue Source on the Molecular and Macroscopic Characteristics of UV-Cured Type I Collagen Hydrogel Networks
The tissue source of type I collagen is critical to ensure scalability and regulation-friendly clinical translation of new medical device prototypes.
A long-lasting guided bone regeneration membrane from sequentially functionalised photoactive atelocollagen
The fast degradation of collagen-based membranes in the biological environment remains a critical challenge, resulting in underperforming Guided Bone Regeneration (GBR) therapy leading to compromised clinical results.
An injectable, self-healing and MMP-inhibiting hyaluronic acid gel via iron coordination
Regulating the activity of matrix metalloproteinases (MMPs) is a potential strategy for osteoarthritis (OA) therapy, although delivering this effect in a spatially and temporally localised fashion remains a challenge.
Hydrolytic Degradability, Cell Tolerance and On-Demand Antibacterial Effect of Electrospun Photodynamically Active Fibres
Photodynamically active fibres (PAFs) are a novel class of stimulus-sensitive systems capable of triggering antibiotic-free antibacterial effect on-demand when exposed to light.
Induced Periosteum-Mimicking Membrane with Cell Barrier and Multipotential Stromal Cell (MSC) Homing Functionalities
Additional to the PL absorption and release capabilities needed for MSC attraction and growth, PCL3%-E also provided a favourable surface for the proliferation and alignment of periosteum- and bone marrow derived-MSCs, whilst possessing a barrier function to cell migration.
Biomimetic peptide enriched nonwoven scaffolds promote calcium phosphate mineralisation
The encapsulation of SAP in a nonwoven system with apatite-forming as well as localised and long-term SAP delivery capabilities is appealing as a potential means of achieving cost-effective bone repair therapy for critical size defects.
In-situ crosslinked wet spun collagen triple helices with nanoscale-regulated ciprofloxacin release capability
The design of antibacterial-releasing coatings or wrapping materials with controlled drug release capability is a promising strategy to minimise risks of infection and medical device failure in vivo.
A redox-responsive hyaluronic acid-based hydrogel for chronic wound management
Polymer-based hydrogels have been widely applied for chronic wound therapeutics, due to their well-acclaimed wound exudate management capability.
Photodynamically Active Electrospun Fibres for Antibiotic-Free Infection Control
With the rising trend in antibiotic resistance, there is a pressing clinical need for new antimicrobial chemistries and biomaterial design approaches enabling on-demand activation of antibiotic-free antimicrobial functionality following an infection that are environment-friendly, flexible and commercially-viable.
