no code implementations • 13 Sep 2022 • M. Ali Al-Radhawi, Shubham Tripathi, Yun Zhang, Eduardo D. Sontag, Herbert Levine
In such models, epigenetic factors are usually proposed to act on the chromatin regions directly involved in the expression of relevant genes.
no code implementations • 27 Nov 2020 • Dongya Jia, Jun Hyoung Park, Harsimran Kaur, Kwang Hwa Jung, Sukjin Yang, Shubham Tripathi, Madeline Galbraith, Youyuan Deng, Mohit Kumar Jolly, Benny Abraham Kaipparettu, Jose N. Onuchic, Herbert Levine
Cancer cells have the plasticity to adjust their metabolic phenotypes for survival and metastasis.
no code implementations • 31 Mar 2020 • Bin Huang, Mingyang Lu, Madeline Galbraith, Herbert Levine, Jose N. Onuchic, Dongya Jia
These gene states can be robustly predicted by the stemness GRN but not by randomized versions of the stemness GRN.
no code implementations • 25 Jul 2019 • Shubham Tripathi, Jianhua Xing, Herbert Levine, Mohit Kumar Jolly
Epithelial-Mesenchymal Transition (EMT), and the corresponding reverse process, Mesenchymal-Epithelial Transition (MET), are dynamic and reversible cellular programs orchestrated by many changes at biochemical and morphological levels.
no code implementations • 16 Apr 2019 • Dongya Jia, Xuefei Li, Federico Bocci, Shubham Tripathi, Youyuan Deng, Mohit Kumar Jolly, Jose N. Onuchic, Herbert Levine
In this review, we first discuss recent efforts combining theoretical and experimental approaches to elucidate mechanisms underlying EMT multi-stability (i. e. the existence of multiple stable phenotypes during EMT) and the properties of hybrid E/M phenotypes.
no code implementations • 13 Feb 2019 • Eial Teomy, David A. Kessler, Herbert Levine
Many developmental processes in biology utilize Notch-Delta signaling to construct an ordered pattern of cellular differentiation.
no code implementations • 18 Mar 2018 • Herbert Levine
Eshel Ben-Jacob, one of the co-organizers of this meeting on collective behavior and one of the pioneers in the field of collective behavior in biology, passed away suddenly just before we convened.