no code implementations • 4 Oct 2024 • Jonathan Horsley, Gerard Hall, Callum Simpson, Csaba Kozma, Rhys Thomas, Yujiang Wang, Jane de Tisi, Anna Miserocchi, Andrew McEvoy, Sjoerd Vos, Gavin Winston, John Duncan, Peter Taylor
Current clinical approaches to identify structural abnormalities for surgical targeting in epilepsy do not use diffusion-weighted MRI (dMRI), despite evidence that dMRI abnormalities are present in epilepsy and may relate to the epileptogenic zone.
no code implementations • 3 Sep 2024 • Nathan Evans, Sarah J. Gascoigne, Guillermo M. Besne, Chris Thornton, Gabrielle M. Schroeder, Fahmida A Chowdhury, Beate Diehl, John S Duncan, Andrew W McEvoy, Anna Miserocchi, Jane de Tisi, Peter N. Taylor, Yujiang Wang
Our objective was to test if this effect was due to limiting seizure spread through early termination of otherwise unchanged seizures.
no code implementations • 11 Aug 2024 • Jonathan Horsley, Yujiang Wang, Callum Simpson, Vyte Janiukstyte, Karoline Leiberg, Beth Little, Jane de Tisi, John Duncan, Peter N. Taylor
Individuals with TLE and SE had reduced entorhinal thickness compared to those with TLE and no history of SE.
no code implementations • 10 Jun 2024 • Peter N. Taylor, Yujiang Wang, Callum Simpson, Vytene Janiukstyte, Jonathan Horsley, Karoline Leiberg, Beth Little, Harry Clifford, Sophie Adler, Sjoerd B. Vos, Gavin P Winston, Andrew W McEvoy, Anna Miserocchi, Jane de Tisi, John S Duncan
To demonstrate the veracity of our data, we successfully replicated previous studies showing long-term outcomes of seizure freedom in the range of around 50%.
1 code implementation • 2 May 2024 • Guillermo M. Besne, Nathan Evans, Mariella Panagiotopoulou, Billy Smith, Fahmida A Chowdhury, Beate Diehl, John S Duncan, Andrew W McEvoy, Anna Miserocchi, Jane de Tisi, Mathew Walker, Peter N. Taylor, Chris Thornton, Yujiang Wang
Anti-seizure medications (ASMs) are the primary treatment for epilepsy, yet medication tapering effects have not been investigated in a dose, region, and time-dependent manner, despite their potential impact on research and clinical practice.
no code implementations • 16 Apr 2024 • Vytene Janiukstyte, Csaba Kozma, Thomas W. Owen, Umair J Chaudhury, Beate Diehl, Louis Lemieux, John S Duncan, Fergus Rugg-Gunn, Jane de Tisi, Yujiang Wang, Peter N. Taylor
Alpha slowing in TLE was found in both EEG and MEG recordings.
no code implementations • 10 Oct 2023 • Csaba Kozma, Gabrielle Schroeder, Tom Owen, Jane de Tisi, Andrew W. McEvoy, Anna Miserocchi, John Duncan, Yujiang Wang, Peter N. Taylor
Combining periodic and aperiodic abnormalities improved performance, similar to the complete band power approach.
no code implementations • 13 Sep 2023 • Christopher Thornton, Mariella Panagiotopoulou, Fahmida A Chowdhury, Beate Diehl, John S Duncan, Sarah J Gascoigne, Guillermo Besne, Andrew W McEvoy, Anna Miserocchi, Billy C Smith, Jane de Tisi, Peter N Taylor, Yujiang Wang
Chronobiological rhythms, such as the circadian rhythm, have long been linked to neurological disorders, but it is currently unknown how pathological processes affect the expression of biological rhythms in the brain.
no code implementations • 11 Apr 2023 • Thomas W. Owen, Vytene Janiukstyte, Gerard R. Hall, Fahmida A. Chowdhury, Beate Diehl, Andrew McEvoy, Anna Miserocchi, Jane de Tisi, John S. Duncan, Fergus Rugg-Gunn, Yujiang Wang, Peter N. Taylor
Finally, we assessed if the implantation of electrodes in abnormal tissue, and resection of the strongest abnormalities determined by MEG and iEEG explained surgical outcome.
no code implementations • 11 Apr 2023 • Thomas W. Owen, Vytene Janiukstyte, Gerard R. Hall, Jonathan J. Horsley, Andrew McEvoy, Anna Miserocchi, Jane de Tisi, John S. Duncan, Fergus Rugg-Gunn, Yujiang Wang, Peter N. Taylor
We quantified the spatial overlap between the abnormality cluster and subsequent resection, hypothesising a greater overlap in seizure-free patients.
no code implementations • 6 Apr 2023 • Jonathan J Horsley, Rhys H Thomas, Fahmida A Chowdhury, Beate Diehl, Andrew W McEvoy, Anna Miserocchi, Jane de Tisi, Sjoerd B Vos, Matthew C Walker, Gavin P Winston, John S Duncan, Yujiang Wang, Peter N Taylor
Here, we investigate whether structural connectivity abnormalities, inferred from dMRI, may be used in conjunction with functional iEEG abnormalities to aid localisation and resection of the epileptogenic zone (EZ), and improve surgical outcomes in epilepsy.
no code implementations • 6 Apr 2023 • Vytene Janiukstyte, Thomas W Owen, Umair J Chaudhary, Beate Diehl, Louis Lemieux, John S Duncan, Jane de Tisi, Yujiang Wang, Peter N Taylor
Scalp EEG relative band power normative maps are spatially stable across time, in keeping with MEG and intracranial EEG results.
no code implementations • 11 Feb 2023 • Yujiang Wang, Gabrielle M Schroeder, Jonathan J Horsley, Mariella Panagiotopoulou, Fahmida A Chowdhury, Beate Diehl, John S Duncan, Andrew W McEvoy, Anna Miserocchi, Jane de Tisi, Peter N Taylor
To assess the localising value of band power abnormality, we computed DRS - a measure of how different the surgically resected and spared tissue were in terms of band power abnormalities - over time.
1 code implementation • 13 Dec 2022 • Karoline Leiberg, Jane de Tisi, John S Duncan, Bethany Little, Peter N Taylor, Sjoerd B Vos, Gavin P Winston, Bruno Mota, Yujiang Wang
Here, we examine the effects of this surgery on cortical morphology measured in independent variables both near the resection and remotely.
no code implementations • 13 Jul 2022 • Thomas W. Owen, Gabrielle M. Schroeder, Vytene Janiukstyte, Gerard R. Hall, Andrew McEvoy, Anna Miserocchi, Jane de Tisi, John S. Duncan, Fergus Rugg-Gunn, Yujiang Wang, Peter N. Taylor
Resting-state MEG data were acquired for 70 healthy controls and 32 patients with refractory neocortical epilepsy.
no code implementations • 17 Apr 2022 • Nishant Sinha, John S. Duncan, Beate Diehl, Fahmida A. Chowdhury, Jane de Tisi, Anna Miserocchi, Andrew W. McEvoy, Kathryn A. Davis, Sjoerd B. Vos, Gavin P. Winston, Yujiang Wang, Peter N. Taylor
We investigated pre-operative structure-function coupling at two spatial scales a) at the global iEEG network level and b) at the resolution of individual iEEG electrode contacts using virtual surgeries.
no code implementations • 5 Feb 2022 • Jonathan J. Horsley, Gabrielle M. Schroeder, Rhys H. Thomas, Jane de Tisi, Sjoerd B. Vos, Gavin P. Winston, John S. Duncan, Yujiang Wang, Peter N. Taylor
We computed grey matter volumetric changes and white matter structural connectivity abnormalities in 144 patients with unilateral TLE and 96 healthy controls.
no code implementations • 10 May 2021 • Peter N Taylor, Christoforos A Papasavvas, Thomas W Owen, Gabrielle M Schroeder, Frances E Hutchings, Fahmida A Chowdhury, Beate Diehl, John S Duncan, Andrew W McEvoy, Anna Miserocchi, Jane de Tisi, Sjoerd B Vos, Matthew C Walker, Yujiang Wang
We then compared interictal recordings from 62 patients with epilepsy to the normative map to identify abnormal regions.