Search Results for author: Jane de Tisi

Found 18 papers, 2 papers with code

Seizure freedom after surgical resection of diffusion-weighted MRI abnormalities

no code implementations4 Oct 2024 Jonathan Horsley, Gerard Hall, Callum Simpson, Csaba Kozma, Rhys Thomas, Yujiang Wang, Jane de Tisi, Anna Miserocchi, Andrew McEvoy, Sjoerd Vos, Gavin Winston, John Duncan, Peter Taylor

Current clinical approaches to identify structural abnormalities for surgical targeting in epilepsy do not use diffusion-weighted MRI (dMRI), despite evidence that dMRI abnormalities are present in epilepsy and may relate to the epileptogenic zone.

Status epilepticus and thinning of the entorhinal cortex

no code implementations11 Aug 2024 Jonathan Horsley, Yujiang Wang, Callum Simpson, Vyte Janiukstyte, Karoline Leiberg, Beth Little, Jane de Tisi, John Duncan, Peter N. Taylor

Individuals with TLE and SE had reduced entorhinal thickness compared to those with TLE and no history of SE.

Anti-seizure medication tapering is associated with delta band power reduction in a dose, region and time-dependent manner

1 code implementation2 May 2024 Guillermo M. Besne, Nathan Evans, Mariella Panagiotopoulou, Billy Smith, Fahmida A Chowdhury, Beate Diehl, John S Duncan, Andrew W McEvoy, Anna Miserocchi, Jane de Tisi, Mathew Walker, Peter N. Taylor, Chris Thornton, Yujiang Wang

Anti-seizure medications (ASMs) are the primary treatment for epilepsy, yet medication tapering effects have not been investigated in a dose, region, and time-dependent manner, despite their potential impact on research and clinical practice.

EEG

Diminished circadian and ultradian rhythms of human brain activity in pathological tissue in vivo

no code implementations13 Sep 2023 Christopher Thornton, Mariella Panagiotopoulou, Fahmida A Chowdhury, Beate Diehl, John S Duncan, Sarah J Gascoigne, Guillermo Besne, Andrew W McEvoy, Anna Miserocchi, Billy C Smith, Jane de Tisi, Peter N Taylor, Yujiang Wang

Chronobiological rhythms, such as the circadian rhythm, have long been linked to neurological disorders, but it is currently unknown how pathological processes affect the expression of biological rhythms in the brain.

EEG

Interictal MEG abnormalities to guide intracranial electrode implantation and predict surgical outcome

no code implementations11 Apr 2023 Thomas W. Owen, Vytene Janiukstyte, Gerard R. Hall, Fahmida A. Chowdhury, Beate Diehl, Andrew McEvoy, Anna Miserocchi, Jane de Tisi, John S. Duncan, Fergus Rugg-Gunn, Yujiang Wang, Peter N. Taylor

Finally, we assessed if the implantation of electrodes in abnormal tissue, and resection of the strongest abnormalities determined by MEG and iEEG explained surgical outcome.

EEG

Complementary structural and functional abnormalities to localise epileptogenic tissue

no code implementations6 Apr 2023 Jonathan J Horsley, Rhys H Thomas, Fahmida A Chowdhury, Beate Diehl, Andrew W McEvoy, Anna Miserocchi, Jane de Tisi, Sjoerd B Vos, Matthew C Walker, Gavin P Winston, John S Duncan, Yujiang Wang, Peter N Taylor

Here, we investigate whether structural connectivity abnormalities, inferred from dMRI, may be used in conjunction with functional iEEG abnormalities to aid localisation and resection of the epileptogenic zone (EZ), and improve surgical outcomes in epilepsy.

EEG

Normative brain mapping using scalp EEG and potential clinical application

no code implementations6 Apr 2023 Vytene Janiukstyte, Thomas W Owen, Umair J Chaudhary, Beate Diehl, Louis Lemieux, John S Duncan, Jane de Tisi, Yujiang Wang, Peter N Taylor

Scalp EEG relative band power normative maps are spatially stable across time, in keeping with MEG and intracranial EEG results.

EEG

Temporal stability of intracranial EEG abnormality maps for localising epileptogenic tissue

no code implementations11 Feb 2023 Yujiang Wang, Gabrielle M Schroeder, Jonathan J Horsley, Mariella Panagiotopoulou, Fahmida A Chowdhury, Beate Diehl, John S Duncan, Andrew W McEvoy, Anna Miserocchi, Jane de Tisi, Peter N Taylor

To assess the localising value of band power abnormality, we computed DRS - a measure of how different the surgically resected and spared tissue were in terms of band power abnormalities - over time.

EEG

Effects of anterior temporal lobe resection on cortical morphology

1 code implementation13 Dec 2022 Karoline Leiberg, Jane de Tisi, John S Duncan, Bethany Little, Peter N Taylor, Sjoerd B Vos, Gavin P Winston, Bruno Mota, Yujiang Wang

Here, we examine the effects of this surgery on cortical morphology measured in independent variables both near the resection and remotely.

Intracranial EEG structure-function coupling predicts surgical outcomes in focal epilepsy

no code implementations17 Apr 2022 Nishant Sinha, John S. Duncan, Beate Diehl, Fahmida A. Chowdhury, Jane de Tisi, Anna Miserocchi, Andrew W. McEvoy, Kathryn A. Davis, Sjoerd B. Vos, Gavin P. Winston, Yujiang Wang, Peter N. Taylor

We investigated pre-operative structure-function coupling at two spatial scales a) at the global iEEG network level and b) at the resolution of individual iEEG electrode contacts using virtual surgeries.

EEG

Volumetric and structural connectivity abnormalities co-localise in TLE

no code implementations5 Feb 2022 Jonathan J. Horsley, Gabrielle M. Schroeder, Rhys H. Thomas, Jane de Tisi, Sjoerd B. Vos, Gavin P. Winston, John S. Duncan, Yujiang Wang, Peter N. Taylor

We computed grey matter volumetric changes and white matter structural connectivity abnormalities in 144 patients with unilateral TLE and 96 healthy controls.

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