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Counterfactual Uncertainty Quantification of Factual Estimand of Efficacy from Before-and-After Treatment Repeated Measures Randomized Controlled Trials
The ideal estimand for comparing treatment $Rx$ with a control $C$ is the $\textit{counterfactual}$ efficacy $Rx:C$, the expected differential outcome between $Rx$ and $C$ if each patient were given $\textit{both}$.
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