Cells with the same genome can exist in different phenotypes.
Phenotype transition takes place in many biological processes such as differentiation, and understanding how a cell reprograms its global gene expression profile is a problem of rate theories.
Epithelial-Mesenchymal Transition (EMT), and the corresponding reverse process, Mesenchymal-Epithelial Transition (MET), are dynamic and reversible cellular programs orchestrated by many changes at biochemical and morphological levels.
no code implementations • 20 Feb 2019 • Oleg Igoshin, Jing Chen, Jianhua Xing, Jian Liu, Timothy C. Elston, Michael Grabe, Kenneth S. Kim, Jasmine Nirody, Padmini Rangamani, Sean Sun, Hongyun Wang, Charles Wolgemuth
Over the past 50 years, the use of mathematical models, derived from physical reasoning, to describe molecular and cellular systems has evolved from an art of the few to a cornerstone of biological inquiry.
Many cellular responses to surrounding cues require temporally concerted transcriptional regulation of multiple genes.