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Spatial clustering and common regulatory elements correlate with coordinated gene expression
Many cellular responses to surrounding cues require temporally concerted transcriptional regulation of multiple genes.
Biophysics at the coffee shop: lessons learned working with George Oster
Over the past 50 years, the use of mathematical models, derived from physical reasoning, to describe molecular and cellular systems has evolved from an art of the few to a cornerstone of biological inquiry.
Mathematical Modeling of Plasticity and Heterogeneity in EMT
Epithelial-Mesenchymal Transition (EMT), and the corresponding reverse process, Mesenchymal-Epithelial Transition (MET), are dynamic and reversible cellular programs orchestrated by many changes at biochemical and morphological levels.
Cell phenotypic transition proceeds through concerted reorganization of gene regulatory network
Phenotype transition takes place in many biological processes such as differentiation, and understanding how a cell reprograms its global gene expression profile is a problem of rate theories.
Reconstructing data-driven governing equations for cell phenotypic transitions: integration of data science and systems biology
Cells with the same genome can exist in different phenotypes.
