Deciphering the unique dynamic activation pathway in a G protein-coupled receptor enables unveiling biased signaling and identifying cryptic allosteric sites in conformational intermediates

no code implementations • 24 Apr 2025 • Jigang Fan, Chunhao Zhu, Xiaobing Lan, Haiming Zhuang, Mingyu Li, Jian Zhang, Shaoyong Lu

Neurotensin receptor 1 (NTSR1), a member of the Class A G protein-coupled receptor superfamily, plays an important role in modulating dopaminergic neuronal activity and eliciting opioid-independent analgesia.