1 code implementation • 5 Mar 2024 • Intekhab Hossain, Jonas Fischer, Rebekka Burkholz, John Quackenbush
The practical utility of machine learning models in the sciences often hinges on their interpretability.
no code implementations • NeurIPS 2021 • Alkis Gotovos, Rebekka Burkholz, John Quackenbush, Stefanie Jegelka
Modeling the time evolution of discrete sets of items (e. g., genetic mutations) is a fundamental problem in many biomedical applications.
1 code implementation • 4 Apr 2021 • Katherine H. Shutta, Deborah Weighill, Rebekka Burkholz, Marouen Ben Guebila, Dawn L. DeMeo, Helena U. Zacharias, John Quackenbush, Michael Altenbuchinger
The increasing quantity of multi-omics data, such as methylomic and transcriptomic profiles, collected on the same specimen, or even on the same cell, provide a unique opportunity to explore the complex interactions that define cell phenotype and govern cellular responses to perturbations.
no code implementations • 11 Jan 2021 • Deborah Weighill, Marouen Ben Guebila, Kimberly Glass, John Platig, Jen Jen Yeh, John Quackenbush
This example demonstrates that gene targeting scores are an invaluable addition to gene expression analysis in the characterization of diseases and other complex phenotypes.
no code implementations • 28 Feb 2020 • Benjamin Haibe-Kains, George Alexandru Adam, Ahmed Hosny, Farnoosh Khodakarami, MAQC Society Board, Levi Waldron, Bo wang, Chris McIntosh, Anshul Kundaje, Casey S. Greene, Michael M. Hoffman, Jeffrey T. Leek, Wolfgang Huber, Alvis Brazma, Joelle Pineau, Robert Tibshirani, Trevor Hastie, John P. A. Ioannidis, John Quackenbush, Hugo J. W. L. Aerts
In their study, McKinney et al. showed the high potential of artificial intelligence for breast cancer screening.
Applications
no code implementations • 9 Sep 2019 • Rebekka Burkholz, John Quackenbush
Cascade models are central to understanding, predicting, and controlling epidemic spreading and information propagation.
3 code implementations • 24 May 2015 • Marieke Lydia Kuijjer, Matthew Tung, Guo-Cheng Yuan, John Quackenbush, Kimberly Glass
We demonstrate the accuracy and applicability of our approach in several data sets, including simulated data, microarray expression data from synchronized yeast cells, and RNA-seq data collected from human lymphoblastoid cell lines.