1 code implementation • 26 Jun 2025 • Sweta Banerjee, Viktoria Weiss, Taryn A. Donovan, Rutger A. Fick, Thomas Conrad, Jonas Ammeling, Nils Porsche, Robert Klopfleisch, Christopher Kaltenecker, Katharina Breininger, Marc Aubreville, Christof A. Bertram
Atypical mitoses mark a deviation in the cell division process that can be an independent prognostically relevant marker for tumor malignancy.
1 code implementation • 8 Jan 2025 • Christof A. Bertram, Viktoria Weiss, Taryn A. Donovan, Sweta Banerjee, Thomas Conrad, Jonas Ammeling, Robert Klopfleisch, Christopher Kaltenecker, Marc Aubreville
Assessment of the density of mitotic figures (MFs) in histologic tumor sections is an important prognostic marker for many tumor types, including breast cancer.
no code implementations • 9 Dec 2024 • Jonathan Ganz, Jonas Ammeling, Emely Rosbach, Ludwig Lausser, Christof A. Bertram, Katharina Breininger, Marc Aubreville
Foundation models (FMs), i. e., models trained on a vast amount of typically unlabeled data, have become popular and available recently for the domain of histopathology.
no code implementations • 28 Jun 2024 • Jonathan Ganz, Christian Marzahl, Jonas Ammeling, Barbara Richter, Chloé Puget, Daniela Denk, Elena A. Demeter, Flaviu A. Tabaran, Gabriel Wasinger, Karoline Lipnik, Marco Tecilla, Matthew J. Valentine, Michael J. Dark, Niklas Abele, Pompei Bolfa, Ramona Erber, Robert Klopfleisch, Sophie Merz, Taryn A. Donovan, Samir Jabari, Christof A. Bertram, Katharina Breininger, Marc Aubreville
Counting MFs on slides stained against PHH3 leads to higher agreement among raters and has therefore recently been used as a ground truth for the annotation of MFs in H&E.
1 code implementation • 11 Apr 2024 • Marc Aubreville, Jonathan Ganz, Jonas Ammeling, Christopher C. Kaltenecker, Christof A. Bertram
The QUILT-1M dataset is the first openly available dataset containing images harvested from various online sources.
no code implementations • 19 Mar 2024 • Jonathan Ganz, Jonas Ammeling, Samir Jabari, Katharina Breininger, Marc Aubreville
We predicted the source patient of a slide with F1 scores of 50. 16 % and 52. 30 % on the LSCC and LUAD datasets, respectively, and with 62. 31 % on our meningioma dataset.
no code implementations • 13 Feb 2024 • Frauke Wilm, Jonas Ammeling, Mathias Öttl, Rutger H. J. Fick, Marc Aubreville, Katharina Breininger
Previous works showed that the trained network layers differ in their susceptibility to this domain shift, e. g., shallow layers are more affected than deeper layers.
no code implementations • 15 Nov 2023 • Jonas Ammeling, Moritz Hecker, Jonathan Ganz, Taryn A. Donovan, Christof A. Bertram, Katharina Breininger, Marc Aubreville
The volume-corrected mitotic index (M/V-Index) was shown to provide prognostic value in invasive breast carcinomas.
no code implementations • 13 Nov 2023 • Marc Aubreville, Zhaoya Pan, Matti Sievert, Jonas Ammeling, Jonathan Ganz, Nicolai Oetter, Florian Stelzle, Ann-Kathrin Frenken, Katharina Breininger, Miguel Goncalves
This method is, in itself, an oversampling procedure, which has a relatively low sensitivity compared to the definitive tissue analysis on paraffin-embedded sections.
no code implementations • 27 Sep 2023 • Marc Aubreville, Nikolas Stathonikos, Taryn A. Donovan, Robert Klopfleisch, Jonathan Ganz, Jonas Ammeling, Frauke Wilm, Mitko Veta, Samir Jabari, Markus Eckstein, Jonas Annuscheit, Christian Krumnow, Engin Bozaba, Sercan Cayir, Hongyan Gu, Xiang 'Anthony' Chen, Mostafa Jahanifar, Adam Shephard, Satoshi Kondo, Satoshi Kasai, Sujatha Kotte, VG Saipradeep, Maxime W. Lafarge, Viktor H. Koelzer, Ziyue Wang, Yongbing Zhang, Sen yang, Xiyue Wang, Katharina Breininger, Christof A. Bertram
The challenge provided annotated histologic tumor images from six different domains and evaluated the algorithmic approaches for mitotic figure detection provided by nine challenge participants on ten independent domains.
no code implementations • 15 Dec 2022 • Jonathan Ganz, Karoline Lipnik, Jonas Ammeling, Barbara Richter, Chloé Puget, Eda Parlak, Laura Diehl, Robert Klopfleisch, Taryn A. Donovan, Matti Kiupel, Christof A. Bertram, Katharina Breininger, Marc Aubreville
Nucleolar organizer regions (NORs) are parts of the DNA that are involved in RNA transcription.
1 code implementation • 15 Dec 2022 • Jonas Ammeling, Lars-Henning Schmidt, Jonathan Ganz, Tanja Niedermair, Christoph Brochhausen-Delius, Christian Schulz, Katharina Breininger, Marc Aubreville
Attention-based multiple instance learning (AMIL) algorithms have proven to be successful in utilizing gigapixel whole-slide images (WSIs) for a variety of different computational pathology tasks such as outcome prediction and cancer subtyping problems.
1 code implementation • 12 Dec 2022 • Marc Aubreville, Jonathan Ganz, Jonas Ammeling, Taryn A. Donovan, Rutger H. J. Fick, Katharina Breininger, Christof A. Bertram
In this work, we perform, for the first time, automatic subtyping of mitotic figures into normal and atypical categories according to characteristic morphological appearances of the different phases of mitosis.