Quantifying cancer epithelial-mesenchymal plasticity and its association with stemness and immune response

no code implementations • 16 Apr 2019 • Dongya Jia, Xuefei Li, Federico Bocci, Shubham Tripathi, Youyuan Deng, Mohit Kumar Jolly, Jose N. Onuchic, Herbert Levine

In this review, we first discuss recent efforts combining theoretical and experimental approaches to elucidate mechanisms underlying EMT multi-stability (i. e. the existence of multiple stable phenotypes during EMT) and the properties of hybrid E/M phenotypes.

Decoding the mechanisms underlying cell-fate decision-making during stem cell differentiation by Random Circuit Perturbation

no code implementations • 31 Mar 2020 • Bin Huang, Mingyang Lu, Madeline Galbraith, Herbert Levine, Jose N. Onuchic, Dongya Jia

These gene states can be robustly predicted by the stemness GRN but not by randomized versions of the stemness GRN.

Decision Making

Towards decoding the coupled decision-making of metabolism and epithelial-mesenchymal transition in cancer

no code implementations • 27 Nov 2020 • Dongya Jia, Jun Hyoung Park, Harsimran Kaur, Kwang Hwa Jung, Sukjin Yang, Shubham Tripathi, Madeline Galbraith, Youyuan Deng, Mohit Kumar Jolly, Benny Abraham Kaipparettu, Jose N. Onuchic, Herbert Levine

Cancer cells have the plasticity to adjust their metabolic phenotypes for survival and metastasis.

Decision Making