no code implementations • 8 Dec 2023 • Pablo Laso, Stefano Cerri, Annabel Sorby-Adams, Jennifer Guo, Farrah Mateen, Philipp Goebl, Jiaming Wu, Peirong Liu, Hongwei Li, Sean I. Young, Benjamin Billot, Oula Puonti, Gordon Sze, Sam Payabavash, Adam DeHavenon, Kevin N. Sheth, Matthew S. Rosen, John Kirsch, Nicola Strisciuglio, Jelmer M. Wolterink, Arman Eshaghi, Frederik Barkhof, W. Taylor Kimberly, Juan Eugenio Iglesias
Brain atrophy and white matter hyperintensity (WMH) are critical neuroimaging features for ascertaining brain injury in cerebrovascular disease and multiple sclerosis.
Here, we propose a SVR method that overcomes the shortcomings of previous work and produces state-of-the-art reconstructions in the presence of extreme inter-slice motion.
Recent learning-based approaches have made astonishing advances in calibrated medical imaging like computerized tomography, yet they struggle to generalize in uncalibrated modalities -- notoriously magnetic resonance imaging (MRI), where performance is highly sensitive to the differences in MR contrast, resolution, and orientation between the training and testing data.
High-resolution fMRI provides a window into the brain's mesoscale organization.
We present USLR, a computational framework for longitudinal registration of brain MRI scans to estimate nonlinear image trajectories that are smooth across time, unbiased to any timepoint, and robust to imaging artefacts.
no code implementations • 24 Sep 2023 • Matthew G. French, Gonzalo D. Maso Talou, Thiranja P. Babarenda Gamage, Martyn P. Nash, Poul M. Nielsen, Anthony J. Doyle, Juan Eugenio Iglesias, Yaël Balbastre, Sean I. Young
In breast surgical planning, accurate registration of MR images across patient positions has the potential to improve the localisation of tumours during breast cancer treatment.
On a multi-centre dataset of 1015 participants with surface-based features and manual lesion masks from structural MRI data, the proposed GCN achieved an AUC of 0. 74, a significant improvement against a previously used vertex-wise multi-layer perceptron (MLP) classifier (AUC 0. 64).
no code implementations • 1 Jun 2023 • Ahmed W. Moawad, Anastasia Janas, Ujjwal Baid, Divya Ramakrishnan, Leon Jekel, Kiril Krantchev, Harrison Moy, Rachit Saluja, Klara Osenberg, Klara Wilms, Manpreet Kaur, Arman Avesta, Gabriel Cassinelli Pedersen, Nazanin Maleki, Mahdi Salimi, Sarah Merkaj, Marc von Reppert, Niklas Tillmans, Jan Lost, Khaled Bousabarah, Wolfgang Holler, MingDe Lin, Malte Westerhoff, Ryan Maresca, Katherine E. Link, Nourel Hoda Tahon, Daniel Marcus, Aristeidis Sotiras, Pamela Lamontagne, Strajit Chakrabarty, Oleg Teytelboym, Ayda Youssef, Ayaman Nada, Yuri S. Velichko, Nicolo Gennaro, Connectome Students, Group of Annotators, Justin Cramer, Derek R. Johnson, Benjamin Y. M. Kwan, Boyan Petrovic, Satya N. Patro, Lei Wu, Tiffany So, Gerry Thompson, Anthony Kam, Gloria Guzman Perez-Carrillo, Neil Lall, Group of Approvers, Jake Albrecht, Udunna Anazodo, Marius George Lingaru, Bjoern H Menze, Benedikt Wiestler, Maruf Adewole, Syed Muhammad Anwar, Dominic LaBella, Hongwei Bran Li, Juan Eugenio Iglesias, Keyvan Farahani, James Eddy, Timothy Bergquist, Verena Chung, Russel Takeshi Shinohara, Farouk Dako, Walter Wiggins, Zachary Reitman, Chunhao Wang, Xinyang Liu, Zhifan Jiang, Koen van Leemput, Marie Piraud, Ivan Ezhov, Elaine Johanson, Zeke Meier, Ariana Familiar, Anahita Fathi Kazerooni, Florian Kofler, Evan Calabrese, Sanjay Aneja, Veronica Chiang, Ichiro Ikuta, Umber Shafique, Fatima Memon, Gian Marco Conte, Spyridon Bakas, Jeffrey Rudie, Mariam Aboian
Clinical monitoring of metastatic disease to the brain can be a laborious and time-consuming process, especially in cases involving multiple metastases when the assessment is performed manually.
no code implementations • 30 May 2023 • Maruf Adewole, Jeffrey D. Rudie, Anu Gbadamosi, Oluyemisi Toyobo, Confidence Raymond, Dong Zhang, Olubukola Omidiji, Rachel Akinola, Mohammad Abba Suwaid, Adaobi Emegoakor, Nancy Ojo, Kenneth Aguh, Chinasa Kalaiwo, Gabriel Babatunde, Afolabi Ogunleye, Yewande Gbadamosi, Kator Iorpagher, Evan Calabrese, Mariam Aboian, Marius Linguraru, Jake Albrecht, Benedikt Wiestler, Florian Kofler, Anastasia Janas, Dominic LaBella, Anahita Fathi Kzerooni, Hongwei Bran Li, Juan Eugenio Iglesias, Keyvan Farahani, James Eddy, Timothy Bergquist, Verena Chung, Russell Takeshi Shinohara, Walter Wiggins, Zachary Reitman, Chunhao Wang, Xinyang Liu, Zhifan Jiang, Ariana Familiar, Koen van Leemput, Christina Bukas, Maire Piraud, Gian-Marco Conte, Elaine Johansson, Zeke Meier, Bjoern H Menze, Ujjwal Baid, Spyridon Bakas, Farouk Dako, Abiodun Fatade, Udunna C Anazodo
Thus, the BraTS-Africa Challenge provides a unique opportunity to include brain MRI glioma cases from SSA in global efforts through the BraTS Challenge to develop and evaluate computer-aided-diagnostic (CAD) methods for the detection and characterization of glioma in resource-limited settings, where the potential for CAD tools to transform healthcare are more likely.
no code implementations • 26 May 2023 • Anahita Fathi Kazerooni, Nastaran Khalili, Xinyang Liu, Debanjan Haldar, Zhifan Jiang, Syed Muhammed Anwar, Jake Albrecht, Maruf Adewole, Udunna Anazodo, Hannah Anderson, Sina Bagheri, Ujjwal Baid, Timothy Bergquist, Austin J. Borja, Evan Calabrese, Verena Chung, Gian-Marco Conte, Farouk Dako, James Eddy, Ivan Ezhov, Ariana Familiar, Keyvan Farahani, Shuvanjan Haldar, Juan Eugenio Iglesias, Anastasia Janas, Elaine Johansen, Blaise V Jones, Florian Kofler, Dominic LaBella, Hollie Anne Lai, Koen van Leemput, Hongwei Bran Li, Nazanin Maleki, Aaron S McAllister, Zeke Meier, Bjoern Menze, Ahmed W Moawad, Khanak K Nandolia, Julija Pavaine, Marie Piraud, Tina Poussaint, Sanjay P Prabhu, Zachary Reitman, Andres Rodriguez, Jeffrey D Rudie, Ibraheem Salman Shaikh, Lubdha M. Shah, Nakul Sheth, Russel Taki Shinohara, Wenxin Tu, Karthik Viswanathan, Chunhao Wang, Jeffrey B Ware, Benedikt Wiestler, Walter Wiggins, Anna Zapaishchykova, Mariam Aboian, Miriam Bornhorst, Peter de Blank, Michelle Deutsch, Maryam Fouladi, Lindsey Hoffman, Benjamin Kann, Margot Lazow, Leonie Mikael, Ali Nabavizadeh, Roger Packer, Adam Resnick, Brian Rood, Arastoo Vossough, Spyridon Bakas, Marius George Linguraru
Pediatric tumors of the central nervous system are the most common cause of cancer-related death in children.
1 code implementation • 15 May 2023 • Florian Kofler, Felix Meissen, Felix Steinbauer, Robert Graf, Eva Oswald, Ezequiel de da Rosa, Hongwei Bran Li, Ujjwal Baid, Florian Hoelzl, Oezguen Turgut, Izabela Horvath, Diana Waldmannstetter, Christina Bukas, Maruf Adewole, Syed Muhammad Anwar, Anastasia Janas, Anahita Fathi Kazerooni, Dominic LaBella, Ahmed W Moawad, Keyvan Farahani, James Eddy, Timothy Bergquist, Verena Chung, Russell Takeshi Shinohara, Farouk Dako, Walter Wiggins, Zachary Reitman, Chunhao Wang, Xinyang Liu, Zhifan Jiang, Ariana Familiar, Gian-Marco Conte, Elaine Johanson, Zeke Meier, Christos Davatzikos, John Freymann, Justin Kirby, Michel Bilello, Hassan M Fathallah-Shaykh, Roland Wiest, Jan Kirschke, Rivka R Colen, Aikaterini Kotrotsou, Pamela Lamontagne, Daniel Marcus, Mikhail Milchenko, Arash Nazeri, Marc-André Weber, Abhishek Mahajan, Suyash Mohan, John Mongan, Christopher Hess, Soonmee Cha, Javier Villanueva-Meyer, Errol Colak, Priscila Crivellaro, Andras Jakab, Jake Albrecht, Udunna Anazodo, Mariam Aboian, Juan Eugenio Iglesias, Koen van Leemput, Spyridon Bakas, Daniel Rueckert, Benedikt Wiestler, Ivan Ezhov, Marie Piraud, Bjoern Menze
The challenge is organized as part of the BraTS 2023 challenge hosted at the MICCAI 2023 conference in Vancouver, Canada.
no code implementations • 15 May 2023 • Hongwei Bran Li, Gian Marco Conte, Syed Muhammad Anwar, Florian Kofler, Ivan Ezhov, Koen van Leemput, Marie Piraud, Maria Diaz, Byrone Cole, Evan Calabrese, Jeff Rudie, Felix Meissen, Maruf Adewole, Anastasia Janas, Anahita Fathi Kazerooni, Dominic LaBella, Ahmed W. Moawad, Keyvan Farahani, Russell Takeshi Shinohara, Farouk Dako, Walter Wiggins, Zachary Reitman, Chunhao Wang, Xinyang Liu, Zhifan Jiang, Ariana Familiar, Elaine Johanson, Zeke Meier, Christos Davatzikos, John Freymann, Justin Kirby, Michel Bilello, Hassan M. Fathallah-Shaykh, Roland Wiest, Jan Kirschke, Rivka R. Colen, Aikaterini Kotrotsou, Pamela Lamontagne, Daniel Marcus, Mikhail Milchenko, Arash Nazeri, Marc André Weber, Abhishek Mahajan, Suyash Mohan, John Mongan, Christopher Hess, Soonmee Cha, Javier Villanueva, Meyer Errol Colak, Priscila Crivellaro, Andras Jakab, Udunna Anazodo, Mariam Aboian, Thomas Yu, Verena Chung, Timothy Bergquist, James Eddy, Jake Albrecht, Ujjwal Baid, Spyridon Bakas, Marius George Linguraru, Bjoern Menze, Juan Eugenio Iglesias, Benedikt Wiestler
In this work, we present the establishment of the Brain MR Image Synthesis Benchmark (BraSyn) in conjunction with the Medical Image Computing and Computer-Assisted Intervention (MICCAI) 2023.
no code implementations • 12 May 2023 • Dominic LaBella, Maruf Adewole, Michelle Alonso-Basanta, Talissa Altes, Syed Muhammad Anwar, Ujjwal Baid, Timothy Bergquist, Radhika Bhalerao, Sully Chen, Verena Chung, Gian-Marco Conte, Farouk Dako, James Eddy, Ivan Ezhov, Devon Godfrey, Fathi Hilal, Ariana Familiar, Keyvan Farahani, Juan Eugenio Iglesias, Zhifan Jiang, Elaine Johanson, Anahita Fathi Kazerooni, Collin Kent, John Kirkpatrick, Florian Kofler, Koen van Leemput, Hongwei Bran Li, Xinyang Liu, Aria Mahtabfar, Shan McBurney-Lin, Ryan McLean, Zeke Meier, Ahmed W Moawad, John Mongan, Pierre Nedelec, Maxence Pajot, Marie Piraud, Arif Rashid, Zachary Reitman, Russell Takeshi Shinohara, Yury Velichko, Chunhao Wang, Pranav Warman, Walter Wiggins, Mariam Aboian, Jake Albrecht, Udunna Anazodo, Spyridon Bakas, Adam Flanders, Anastasia Janas, Goldey Khanna, Marius George Linguraru, Bjoern Menze, Ayman Nada, Andreas M Rauschecker, Jeff Rudie, Nourel Hoda Tahon, Javier Villanueva-Meyer, Benedikt Wiestler, Evan Calabrese
Meningiomas are the most common primary intracranial tumor in adults and can be associated with significant morbidity and mortality.
no code implementations • 5 May 2023 • Henry F. J. Tregidgo, Sonja Soskic, Mark D. Olchanyi, Juri Althonayan, Benjamin Billot, Chiara Maffei, Polina Golland, Anastasia Yendiki, Daniel C. Alexander, Martina Bocchetta, Jonathan D. Rohrer, Juan Eugenio Iglesias
Some tools have attempted to incorporate information from diffusion MRI in the segmentation to refine these boundaries, but do not generalise well across diffusion MRI acquisitions.
Here we present the first method for cortical reconstruction, registration, parcellation, and thickness estimation for clinical brain MRI scans of any resolution and pulse sequence.
no code implementations • 3 Dec 2022 • Hongwei Bran Li, Chinmay Prabhakar, Suprosanna Shit, Johannes Paetzold, Tamaz Amiranashvili, JianGuo Zhang, Daniel Rueckert, Juan Eugenio Iglesias, Benedikt Wiestler, Bjoern Menze
We find that in the natural image domain, CSR behaves on par with the supervised one on several perceptual tests as a metric, and in the medical domain, CSR better quantifies perceptual similarity concerning the experts' ratings.
Experiments with real-world MRI data are also performed to demonstrate the ability of the proposed model to improve the quality of 3D reconstruction under severe fetal motion.
In recent years, learning-based image registration methods have gradually moved away from direct supervision with target warps to instead use self-supervision, with excellent results in several registration benchmarks.
no code implementations • 7 Feb 2022 • Juan Eugenio Iglesias, Riana Schleicher, Sonia Laguna, Benjamin Billot, Pamela Schaefer, Brenna McKaig, Joshua N. Goldstein, Kevin N. Sheth, Matthew S. Rosen, W. Taylor Kimberly
To address this challenge, recent advances in machine learning facilitate the synthesis of higher resolution images derived from one or multiple lower resolution scans.
SUD unifies stochastic averaging and spatial denoising techniques under a spatio-temporal denoising framework and alternates denoising and model weight update steps in an optimization framework for semi-supervision.
Nonlinear inter-modality registration is often challenging due to the lack of objective functions that are good proxies for alignment.
Here we introduce SynthSeg, the first segmentation CNN robust against changes in contrast and resolution.
1 code implementation • 21 Jun 2021 • Carolyna Hepburn, Alexis Jones, Alan Bainbridge, Coziana Ciurtin, Juan Eugenio Iglesias, HUI ZHANG, Margaret A. Hall-Craggs, Timothy JP Bray, . Joint senior authorship.
Short inversion time inversion recovery (STIR) MRI is widely used in clinical practice to identify and quantify inflammation in axial spondyloarthritis.
The model relies on a spanning tree of latent transforms connecting all the sections and slices of the reference volume, and assumes that the registration between any pair of images can be see as a noisy version of the composition of (possibly inverted) latent transforms connecting the two images.
In this paper, we introduce a principled strategy for the construction of a gold standard in deformable registration.
In addition to the efficient construction of a mosaic, our framework provides, as a by-product, ground truth landmark correspondences which can be used for evaluation or learning purposes.
Most existing algorithms for automatic 3D morphometry of human brain MRI scans are designed for data with near-isotropic voxels at approximately 1 mm resolution, and frequently have contrast constraints as well - typically requiring T1 scans (e. g., MP-RAGE).
1 code implementation • 4 Nov 2020 • Yunguan Fu, Nina Montaña Brown, Shaheer U. Saeed, Adrià Casamitjana, Zachary M. C. Baum, Rémi Delaunay, Qianye Yang, Alexander Grimwood, Zhe Min, Stefano B. Blumberg, Juan Eugenio Iglesias, Dean C. Barratt, Ester Bonmati, Daniel C. Alexander, Matthew J. Clarkson, Tom Vercauteren, Yipeng Hu
DeepReg (https://github. com/DeepRegNet/DeepReg) is a community-supported open-source toolkit for research and education in medical image registration using deep learning.
1 code implementation • 11 Sep 2020 • Henry Tregidgo, Adria Casamitjana, Caitlin Latimer, Mitchell Kilgore, Eleanor Robinson, Emily Blackburn, Koen van Leemput, Bruce Fischl, Adrian Dalca, Christine Mac Donald, Dirk Keene, Juan Eugenio Iglesias
NTNC traditionally requires a volumetric MRI scan, acquired either ex vivo or a short time prior to death.
This is in contrast to most current deep learning approaches for image reconstruction that treat frequency and image space features separately and often operate exclusively in one of the two spaces.
Thus there is a strong need for deep learning-based segmentation tools that do not require heavy supervision and can continuously adapt.
This approach results in powerful networks that accurately generalize to a broad array of MRI contrasts.
Partial voluming (PV) is arguably the last crucial unsolved problem in Bayesian segmentation of brain MRI with probabilistic atlases.
These samples are produced using the generative model of the classical Bayesian segmentation framework, with randomly sampled parameters for appearance, deformation, noise, and bias field.
Ranked #1 on Brain Segmentation on Brain MRI segmentation
To develop a deep learning-based segmentation model for a new image dataset (e. g., of different contrast), one usually needs to create a new labeled training dataset, which can be prohibitively expensive, or rely on suboptimal ad hoc adaptation or augmentation approaches.
Segmentation of structural and diffusion MRI (sMRI/dMRI) is usually performed independently in neuroimaging pipelines.
State-of-the-art deep learning methods for image processing are evolving into increasingly complex meta-architectures with a growing number of modules.
no code implementations • 22 Jun 2018 • Juan Eugenio Iglesias, Ricardo Insausti, Garikoitz Lerma-Usabiaga, Martina Bocchetta, Koen van Leemput, Douglas N. Greve, Andre van der Kouwe, Bruce Fischl, Cesar Caballero-Gaudes, Pedro M Paz-Alonso
In this study, we present a probabilistic atlas of the thalamic nuclei built using ex vivo brain MRI scans and histological data, as well as the application of the atlas to in vivo MRI segmentation.
Here, we overcome this limitation with a probabilistic method that simultaneously solves for registration and synthesis directly on the target images, without any training data.
We propose here a novel automatic approach to the joint problem of multimodal registration between histology and MRI, when only a fraction of tissue is available from histology.
Finally, our goal is to also present a perspective on the future of MAS, which, we believe, will be one of the dominant approaches in biomedical image segmentation.