Search Results for author: Ka-Chun Wong

Found 14 papers, 5 papers with code

A versatile informative diffusion model for single-cell ATAC-seq data generation and analysis

no code implementations27 Aug 2024 Lei Huang, Lei Xiong, Na Sun, Zunpeng Liu, Ka-Chun Wong, Manolis Kellis

ATAC-Diff is the first diffusion model for the scATAC-seq data generation and analysis, composed of auxiliary modules encoding the latent high-level variables to enable the model to learn the semantic information to sample high-quality data.

Exhaustive Exploitation of Nature-inspired Computation for Cancer Screening in an Ensemble Manner

1 code implementation6 Apr 2024 Xubin Wang, Yunhe Wang, Zhiqing Ma, Ka-Chun Wong, Xiangtao Li

This study presents a framework termed Evolutionary Optimized Diverse Ensemble Learning (EODE) to improve ensemble learning for cancer classification from gene expression data.

Diversity Ensemble Learning +2

DiffDTM: A conditional structure-free framework for bioactive molecules generation targeted for dual proteins

no code implementations24 Jun 2023 Lei Huang, Zheng Yuan, Huihui Yan, Rong Sheng, Linjing Liu, Fuzhou Wang, Weidun Xie, Nanjun Chen, Fei Huang, Songfang Huang, Ka-Chun Wong, Yaoyun Zhang

However, molecule generation targeted for dual protein targets still faces formidable challenges including protein 3D structure data requisition for model training, auto-regressive sampling, and model generalization for unseen targets.

A Block-Based Adaptive Decoupling Framework for Graph Neural Networks

1 code implementation Entropy 2022, 24(9), 1190; 2022 Xu Shen, Yuyang Zhang, Yu Xie, Ka-Chun Wong, Chengbin Peng

Graph neural networks (GNNs) with feature propagation have demonstrated their power in handling unstructured data.

Diversity

EGFI: Drug-Drug Interaction Extraction and Generation with Fusion of Enriched Entity and Sentence Information

1 code implementation25 Jan 2021 Lei Huang, Jiecong Lin, Xiangtao Li, Linqi Song, Ka-Chun Wong

To address such a problem, we propose EGFI for extracting and consolidating drug interactions from large-scale medical literature text data.

Classification Drug–drug Interaction Extraction +3

Review of Single-cell RNA-seq Data Clustering for Cell Type Identification and Characterization

no code implementations3 Jan 2020 Shi-Xiong Zhang, Xiangtao Li, Qiuzhen Lin, Ka-Chun Wong

In recent years, the advances in single-cell RNA-seq techniques have enabled us to perform large-scale transcriptomic profiling at single-cell resolution in a high-throughput manner.

Clustering Dimensionality Reduction

Big Data Challenges in Genome Informatics

no code implementations20 Mar 2018 Ka-Chun Wong

In recent years, we have witnessed a dramatic data explosion in genomics, thanks to the improvement in sequencing technologies and the drastically decreasing costs.

A Short Survey on Data Clustering Algorithms

no code implementations25 Nov 2015 Ka-Chun Wong

With rapidly increasing data, clustering algorithms are important tools for data analytics in modern research.

Clustering Financial Analysis +2

Unsupervised Learning in Genome Informatics

no code implementations3 Aug 2015 Ka-Chun Wong, Yue Li, Zhaolei Zhang

Here we review several unsupervised learning methods for deciphering the genome-wide patterns of those DNA regions.

Evolutionary Multimodal Optimization: A Short Survey

no code implementations3 Aug 2015 Ka-Chun Wong

Unfortunately, most traditional optimization techniques focus on solving for a single optimal solution.

Benchmarking Diversity +1

Evolutionary Algorithms: Concepts, Designs, and Applications in Bioinformatics: Evolutionary Algorithms for Bioinformatics

no code implementations3 Aug 2015 Ka-Chun Wong

Since genetic algorithm was proposed by John Holland (Holland J. H., 1975) in the early 1970s, the study of evolutionary algorithm has emerged as a popular research field (Civicioglu & Besdok, 2013).

Evolutionary Algorithms

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