no code implementations • 27 Aug 2024 • Lei Huang, Lei Xiong, Na Sun, Zunpeng Liu, Ka-Chun Wong, Manolis Kellis
ATAC-Diff is the first diffusion model for the scATAC-seq data generation and analysis, composed of auxiliary modules encoding the latent high-level variables to enable the model to learn the semantic information to sample high-quality data.
1 code implementation • 6 Apr 2024 • Xubin Wang, Yunhe Wang, Zhiqing Ma, Ka-Chun Wong, Xiangtao Li
This study presents a framework termed Evolutionary Optimized Diverse Ensemble Learning (EODE) to improve ensemble learning for cancer classification from gene expression data.
no code implementations • 24 Jun 2023 • Lei Huang, Zheng Yuan, Huihui Yan, Rong Sheng, Linjing Liu, Fuzhou Wang, Weidun Xie, Nanjun Chen, Fei Huang, Songfang Huang, Ka-Chun Wong, Yaoyun Zhang
However, molecule generation targeted for dual protein targets still faces formidable challenges including protein 3D structure data requisition for model training, auto-regressive sampling, and model generalization for unseen targets.
no code implementations • 13 Sep 2022 • Lei Huang, Hengtong Zhang, Tingyang Xu, Ka-Chun Wong
At the same time, the generated molecules lack enough diversity.
1 code implementation • Entropy 2022, 24(9), 1190; 2022 • Xu Shen, Yuyang Zhang, Yu Xie, Ka-Chun Wong, Chengbin Peng
Graph neural networks (GNNs) with feature propagation have demonstrated their power in handling unstructured data.
1 code implementation • 27 Oct 2021 • Xubin Wang, Yunhe Wang, Ka-Chun Wong, Xiangtao Li
We demonstrate the effectiveness of our algorithm on twelve large-scale datasets.
1 code implementation • 25 Jan 2021 • Lei Huang, Jiecong Lin, Xiangtao Li, Linqi Song, Ka-Chun Wong
To address such a problem, we propose EGFI for extracting and consolidating drug interactions from large-scale medical literature text data.
no code implementations • 3 Jan 2020 • Shi-Xiong Zhang, Xiangtao Li, Qiuzhen Lin, Ka-Chun Wong
In recent years, the advances in single-cell RNA-seq techniques have enabled us to perform large-scale transcriptomic profiling at single-cell resolution in a high-throughput manner.
1 code implementation • 2 May 2019 • Shankai Yan, Ka-Chun Wong
We built our models on the datasets from BioNLP Shared Task for evaluations.
no code implementations • 20 Mar 2018 • Ka-Chun Wong
In recent years, we have witnessed a dramatic data explosion in genomics, thanks to the improvement in sequencing technologies and the drastically decreasing costs.
no code implementations • 25 Nov 2015 • Ka-Chun Wong
With rapidly increasing data, clustering algorithms are important tools for data analytics in modern research.
no code implementations • 3 Aug 2015 • Ka-Chun Wong, Yue Li, Zhaolei Zhang
Here we review several unsupervised learning methods for deciphering the genome-wide patterns of those DNA regions.
no code implementations • 3 Aug 2015 • Ka-Chun Wong
Unfortunately, most traditional optimization techniques focus on solving for a single optimal solution.
no code implementations • 3 Aug 2015 • Ka-Chun Wong
Since genetic algorithm was proposed by John Holland (Holland J. H., 1975) in the early 1970s, the study of evolutionary algorithm has emerged as a popular research field (Civicioglu & Besdok, 2013).