no code implementations • 16 Apr 2020 • Masaki Watabe, Hideaki Yoshimura, Satya N. V. Arjunan, Kazunari Kaizu, Koichi Takahashi
Eukaryotic cells transmit extracellular signal information to cellular interiors through the formation of a ternary complex made up of a ligand (or agonist), G-protein, and G-protein coupled receptor (GPCR).
no code implementations • 27 May 2019 • Masaki Watabe, Satya N. V. Arjunan, Wei Xiang Chew, Kazunari Kaizu, Koichi Takahashi
While cooperativity in ligand-induced receptor dimerization has been linked with receptor-receptor couplings via minimal representations of physical observables, effects arising from higher-order oligomer (e. g., trimer and tetramer) formations of unobserved receptors have received less attention.
no code implementations • 17 Nov 2018 • Wei-Xiang Chew, Kazunari Kaizu, Masaki Watabe, Sithi V. Muniandy, Koichi Takahashi, Satya N. V. Arjunan
Microscopic models of reaction-diffusion processes on the cell membrane can link local spatiotemporal effects to macroscopic self-organized patterns often observed on the membrane.
no code implementations • 31 May 2018 • Wei-Xiang Chew, Kazunari Kaizu, Masaki Watabe, Sithi V. Muniandy, Koichi Takahashi, Satya N. V. Arjunan
Some of these schemes that are based on the reaction-diffusion master equation (RDME), can simulate for extended spatial and temporal scales but cannot directly account for the microscopic effects in the cell such as volume exclusion and diffusion-influenced reactions.
