no code implementations • 17 May 2023 • Keqi Wang, Wei Xie, Hua Zheng
To facilitate a rapid response to pandemic threats, this paper focuses on developing a mechanistic simulation model for in vitro transcription (IVT) process, a crucial step in mRNA vaccine manufacturing.
no code implementations • 29 Apr 2023 • Keqi Wang, Wei Xie, Sarah W. Harcum
In this paper, a metabolic kinetic model was developed to characterize underlying mechanisms of iPSC culture process, which can predict cell response to environmental perturbation and support process control.
no code implementations • 5 May 2022 • Wei Xie, Keqi Wang, Hua Zheng, Ben Feng
Driven by the critical needs of biomanufacturing 4. 0, we introduce a probabilistic knowledge graph hybrid model characterizing the risk- and science-based understanding of bioprocess mechanisms.
no code implementations • 22 Jan 2022 • Keqi Wang, Ziteng Cui, Jieru Jia, Hao Xu, Ge Wu, Yin Zhuang, Lu Chen, Zhiguo Hu, Yuhua Qian
However, the convolution operation is based on a local sliding window mechanism, which is difficult to construct the long-range dependencies of the feature maps.
no code implementations • 10 Jan 2022 • Hua Zheng, Wei Xie, Keqi Wang, Zheng Li
Driven by the key challenges of cell therapy manufacturing, including high complexity, high uncertainty, and very limited process observations, we propose a hybrid model-based reinforcement learning (RL) to efficiently guide process control.
no code implementations • 16 May 2020 • Keqi Wang, Peng Gao, Steven Hoi, Qian Guo, Yuhua Qian
Low-light imaging is challenging since images may appear to be dark and noised due to low signal-to-noise ratio, complex image content, and the variety in shooting scenes in extreme low-light condition.