Search Results for author: Manolis Kellis

Found 10 papers, 3 papers with code

ProteinRPN: Towards Accurate Protein Function Prediction with Graph-Based Region Proposals

no code implementations1 Sep 2024 Shania Mitra, Lei Huang, Manolis Kellis

Specifically, the region proposal module component of ProteinRPN identifies potential functional regions (anchors) which are refined through the hierarchy-aware node drop pooling layer favoring nodes with defined secondary structures and spatial proximity.

Protein Function Prediction Region Proposal

A versatile informative diffusion model for single-cell ATAC-seq data generation and analysis

no code implementations27 Aug 2024 Lei Huang, Lei Xiong, Na Sun, Zunpeng Liu, Ka-Chun Wong, Manolis Kellis

ATAC-Diff is the first diffusion model for the scATAC-seq data generation and analysis, composed of auxiliary modules encoding the latent high-level variables to enable the model to learn the semantic information to sample high-quality data.

Contextualized Machine Learning

no code implementations17 Oct 2023 Benjamin Lengerich, Caleb N. Ellington, Andrea Rubbi, Manolis Kellis, Eric P. Xing

Contextualized ML estimates heterogeneous functions by applying deep learning to the meta-relationship between contextual information and context-specific parametric models.

LLMs Understand Glass-Box Models, Discover Surprises, and Suggest Repairs

1 code implementation2 Aug 2023 Benjamin J. Lengerich, Sebastian Bordt, Harsha Nori, Mark E. Nunnally, Yin Aphinyanaphongs, Manolis Kellis, Rich Caruana

We show that large language models (LLMs) are remarkably good at working with interpretable models that decompose complex outcomes into univariate graph-represented components.

Additive models

NOTMAD: Estimating Bayesian Networks with Sample-Specific Structures and Parameters

1 code implementation1 Nov 2021 Ben Lengerich, Caleb Ellington, Bryon Aragam, Eric P. Xing, Manolis Kellis

We encode the acyclicity constraint as a smooth regularization loss which is back-propagated to the mixing function; in this way, NOTMAD shares information between context-specific acyclic graphs, enabling the estimation of Bayesian network structures and parameters at even single-sample resolution.

Causal Mediation Analysis Leveraging Multiple Types of Summary Statistics Data

no code implementations24 Jan 2019 Yongjin Park, Abhishek Sarkar, Khoi Nguyen, Manolis Kellis

We can achieve necessary interpretation of GWAS in a causal mediation framework, looking to establish a sparse set of mediators between genetic and downstream variables, but there are several challenges.

Causal Inference

A latent topic model for mining heterogenous non-randomly missing electronic health records data

no code implementations1 Nov 2018 Yue Li, Manolis Kellis

Electronic health records (EHR) are rich heterogeneous collection of patient health information, whose broad adoption provides great opportunities for systematic health data mining.

Collaborative Filtering Topic Models

Network Maximal Correlation

no code implementations15 Jun 2016 Soheil Feizi, Ali Makhdoumi, Ken Duffy, Muriel Medard, Manolis Kellis

For jointly Gaussian variables, we show that under some conditions the NMC optimization is an instance of the Max-Cut problem.

graph partitioning

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