no code implementations • 1 Sep 2024 • Shania Mitra, Lei Huang, Manolis Kellis
Specifically, the region proposal module component of ProteinRPN identifies potential functional regions (anchors) which are refined through the hierarchy-aware node drop pooling layer favoring nodes with defined secondary structures and spatial proximity.
no code implementations • 27 Aug 2024 • Lei Huang, Lei Xiong, Na Sun, Zunpeng Liu, Ka-Chun Wong, Manolis Kellis
ATAC-Diff is the first diffusion model for the scATAC-seq data generation and analysis, composed of auxiliary modules encoding the latent high-level variables to enable the model to learn the semantic information to sample high-quality data.
1 code implementation • 10 Jan 2024 • Yue Huang, Lichao Sun, Haoran Wang, Siyuan Wu, Qihui Zhang, Yuan Li, Chujie Gao, Yixin Huang, Wenhan Lyu, Yixuan Zhang, Xiner Li, Zhengliang Liu, Yixin Liu, Yijue Wang, Zhikun Zhang, Bertie Vidgen, Bhavya Kailkhura, Caiming Xiong, Chaowei Xiao, Chunyuan Li, Eric Xing, Furong Huang, Hao liu, Heng Ji, Hongyi Wang, huan zhang, Huaxiu Yao, Manolis Kellis, Marinka Zitnik, Meng Jiang, Mohit Bansal, James Zou, Jian Pei, Jian Liu, Jianfeng Gao, Jiawei Han, Jieyu Zhao, Jiliang Tang, Jindong Wang, Joaquin Vanschoren, John Mitchell, Kai Shu, Kaidi Xu, Kai-Wei Chang, Lifang He, Lifu Huang, Michael Backes, Neil Zhenqiang Gong, Philip S. Yu, Pin-Yu Chen, Quanquan Gu, ran Xu, Rex Ying, Shuiwang Ji, Suman Jana, Tianlong Chen, Tianming Liu, Tianyi Zhou, William Wang, Xiang Li, Xiangliang Zhang, Xiao Wang, Xing Xie, Xun Chen, Xuyu Wang, Yan Liu, Yanfang Ye, Yinzhi Cao, Yong Chen, Yue Zhao
This paper introduces TrustLLM, a comprehensive study of trustworthiness in LLMs, including principles for different dimensions of trustworthiness, established benchmark, evaluation, and analysis of trustworthiness for mainstream LLMs, and discussion of open challenges and future directions.
no code implementations • 17 Oct 2023 • Benjamin Lengerich, Caleb N. Ellington, Andrea Rubbi, Manolis Kellis, Eric P. Xing
Contextualized ML estimates heterogeneous functions by applying deep learning to the meta-relationship between contextual information and context-specific parametric models.
1 code implementation • 2 Aug 2023 • Benjamin J. Lengerich, Sebastian Bordt, Harsha Nori, Mark E. Nunnally, Yin Aphinyanaphongs, Manolis Kellis, Rich Caruana
We show that large language models (LLMs) are remarkably good at working with interpretable models that decompose complex outcomes into univariate graph-represented components.
1 code implementation • 1 Nov 2021 • Ben Lengerich, Caleb Ellington, Bryon Aragam, Eric P. Xing, Manolis Kellis
We encode the acyclicity constraint as a smooth regularization loss which is back-propagated to the mixing function; in this way, NOTMAD shares information between context-specific acyclic graphs, enabling the estimation of Bayesian network structures and parameters at even single-sample resolution.
no code implementations • 24 Jan 2019 • Yongjin Park, Abhishek Sarkar, Khoi Nguyen, Manolis Kellis
We can achieve necessary interpretation of GWAS in a causal mediation framework, looking to establish a sparse set of mediators between genetic and downstream variables, but there are several challenges.
no code implementations • 1 Nov 2018 • Yue Li, Manolis Kellis
Electronic health records (EHR) are rich heterogeneous collection of patient health information, whose broad adoption provides great opportunities for systematic health data mining.
no code implementations • 15 Jun 2016 • Soheil Feizi, Ali Makhdoumi, Ken Duffy, Muriel Medard, Manolis Kellis
For jointly Gaussian variables, we show that under some conditions the NMC optimization is an instance of the Max-Cut problem.
no code implementations • 23 Nov 2014 • Nematollah Kayhan Batmanghelich, Gerald Quon, Alex Kulesza, Manolis Kellis, Polina Golland, Luke Bornn
We propose a novel diverse feature selection method based on determinantal point processes (DPPs).