no code implementations • 27 Mar 2022 • Mingju Cao, Shikha Kuthiala, Keven Jason Jean, Hai Lun Liu, Marc Courchesne, Karen Nygard, Patrick Burns, André Desrochers, Gilles Fecteau, Christophe Faure, Martin G. Frasch
Under conditions of moderate fetal inflammation, this is related to higher levels of gut inflammation; the efferent VNS reduces the systemic inflammatory response as well as restores both the levels of glucose and terminal ileum inflammation, but not the insulin levels.
In addition, this paper will focus on which factors (i. e. fetal characteristics and behaviors, maternal lifestyle and pathologies, placental health and dysfunction, labor, incubator conditions, and drug exposure) may have an impact on the development of the vagus during the above-mentioned "critical window" and how.
Ultimately, such a system could enable a physician to timely respond during labor and prevent adverse outcomes.
no code implementations • 26 May 2021 • Peter Zimmermann, Marta C. Antonelli, Ritika Sharma, Alexander Müller, Camilla Zelgert, Bibiana Fabre, Natasha Wenzel, Hau-Tieng Wu, Martin G. Frasch, Silvia M. Lobmaier
What is the influence of chronic maternal prenatal stress (PS) on fetal iron homeostasis?
We expand from a spontaneous to an evoked potentials (EP) data set of brain electrical activities as electrocorticogram (ECoG) and electrothalamogram (EThG) in juvenile pig under various sedation, ischemia and recovery states.
Our DL models accurately detect the chronic stress exposure group (AUROC=0. 982+/-0. 002), the individual psychological stress score (R2=0. 943+/-0. 009) and FSI at 34 weeks of gestation (R2=0. 946+/-0. 013), as well as the maternal hair cortisol at birth reflecting chronic stress exposure (0. 931+/-0. 006).
no code implementations • 19 Aug 2020 • Aude Castel, Patrick M. Burns, Javier Benito, Hai L. Liu, Shikha Kuthiala, Lucien D. Durosier, Yael S. Frank, Mingju Cao, Marilène Paquet, Gilles Fecteau, André Desrochers, Martin G. Frasch
Conclusions: This study describes a new surgical procedure allowing to record and manipulate chronically the vagus nerve activity in an animal model of human pregnancy.
Background: Studies about the feasibility of monitoring fetal electroencephalogram (fEEG) during labor began in the early 1940s.
Chronic fetal hypoxia and infection are examples of adverse conditions during complicated pregnancy, which impact cardiac myogenesis and increase the lifetime risk of heart disease.
Ischemic brain injuries are frequent and difficult to detect reliably or early.
Heart rate variability (HRV) has been studied for over 50 years, yet an integrative concept is missing on what HRV's mathematical properties represent physiologically.
Fetal neuroinflammation and prenatal stress (PS) may contribute to lifelong neurological disabilities.
We review evidence supporting the role of early life programming in the susceptibility for adult neurodegenerative diseases while highlighting questions and proposing avenues for future research to advance our understanding of this fundamental process.
However, in this setup the data calibration issue is often not discussed and, rather, implicitly assumed, while the clinical monitors might not be designed for the data analysis purpose.
High-frequency heart rate variability (HRV) has identified parasympathetic nervous system alterations in autism spectrum disorder (ASD).
Quantitative Methods Neurons and Cognition
There is a need for affordable, widely deployable maternal-fetal ECG monitors to improve maternal and fetal health during pregnancy and delivery.