no code implementations • 2 Jan 2024 • Chloé Puget, Jonathan Ganz, Julian Ostermaier, Thomas Konrad, Eda Parlak, Christof Albert Bertram, Matti Kiupel, Katharina Breininger, Marc Aubreville, Robert Klopfleisch
This project aimed at training deep learning models (DLMs) to identify the c-Kit-11 mutational status of MCTs solely based on morphology without additional molecular analysis.
no code implementations • 26 Sep 2023 • Andreas Haghofer, Eda Parlak, Alexander Bartel, Taryn A. Donovan, Charles-Antoine Assenmacher, Pompei Bolfa, Michael J. Dark, Andrea Fuchs-Baumgartinger, Andrea Klang, Kathrin Jäger, Robert Klopfleisch, Sophie Merz, Barbara Richter, F. Yvonne Schulman, Hannah Janout, Jonathan Ganz, Josef Scharinger, Marc Aubreville, Stephan M. Winkler, Matti Kiupel, Christof A. Bertram
We assessed the following nuclear evaluation methods for measurement accuracy, reproducibility, and prognostic utility: 1) anisokaryosis (karyomegaly) estimates by 11 pathologists; 2) gold standard manual morphometry of at least 100 nuclei; 3) practicable manual morphometry with stratified sampling of 12 nuclei by 9 pathologists; and 4) automated morphometry using a deep learning-based segmentation algorithm.
no code implementations • 15 Dec 2022 • Jonathan Ganz, Karoline Lipnik, Jonas Ammeling, Barbara Richter, Chloé Puget, Eda Parlak, Laura Diehl, Robert Klopfleisch, Taryn A. Donovan, Matti Kiupel, Christof A. Bertram, Katharina Breininger, Marc Aubreville
Nucleolar organizer regions (NORs) are parts of the DNA that are involved in RNA transcription.
no code implementations • 4 Dec 2020 • Frauke Wilm, Christof A. Bertram, Christian Marzahl, Alexander Bartel, Taryn A. Donovan, Charles-Antoine Assenmacher, Kathrin Becker, Mark Bennett, Sarah Corner, Brieuc Cossic, Daniela Denk, Martina Dettwiler, Beatriz Garcia Gonzalez, Corinne Gurtner, Annika Lehmbecker, Sophie Merz, Stephanie Plog, Anja Schmidt, Rebecca C. Smedley, Marco Tecilla, Tuddow Thaiwong, Katharina Breininger, Matti Kiupel, Andreas Maier, Robert Klopfleisch, Marc Aubreville
Density of mitotic figures in histologic sections is a prognostically relevant characteristic for many tumours.