Structure-Enhanced Protein Instruction Tuning: Towards General-Purpose Protein Understanding

no code implementations • 4 Oct 2024 • Wei Wu, Chao Wang, Liyi Chen, Mingze Yin, Yiheng Zhu, Kun fu, Jieping Ye, Hui Xiong, Zheng Wang

Recent development of protein language models (pLMs) with supervised fine tuning provides a promising solution to this problem.

Multi-Modal CLIP-Informed Protein Editing

no code implementations • 27 Jul 2024 • Mingze Yin, Hanjing Zhou, Yiheng Zhu, Miao Lin, Yixuan Wu, Jialu Wu, Hongxia Xu, Chang-Yu Hsieh, Tingjun Hou, Jintai Chen, Jian Wu

Proteins govern most biological functions essential for life, but achieving controllable protein discovery and optimization remains challenging.

Attribute Contrastive Learning

Group-On: Boosting One-Shot Segmentation with Supportive Query

no code implementations • 18 Apr 2024 • Hanjing Zhou, Mingze Yin, Jintai Chen, Danny Chen, Jian Wu

One-shot semantic segmentation aims to segment query images given only ONE annotated support image of the same class.

One-Shot Segmentation Segmentation

Generative AI for Controllable Protein Sequence Design: A Survey

no code implementations • 16 Feb 2024 • Yiheng Zhu, Zitai Kong, Jialu Wu, Weize Liu, Yuqiang Han, Mingze Yin, Hongxia Xu, Chang-Yu Hsieh, Tingjun Hou

To set the stage, we first outline the foundational tasks in protein sequence design in terms of the constraints involved and present key generative models and optimization algorithms.

Drug Discovery Protein Design +1