no code implementations • 27 Nov 2020 • Dongya Jia, Jun Hyoung Park, Harsimran Kaur, Kwang Hwa Jung, Sukjin Yang, Shubham Tripathi, Madeline Galbraith, Youyuan Deng, Mohit Kumar Jolly, Benny Abraham Kaipparettu, Jose N. Onuchic, Herbert Levine
Cancer cells have the plasticity to adjust their metabolic phenotypes for survival and metastasis.
Notch signaling is an evolutionary conserved cell-cell communication pathway.
Epithelial-Mesenchymal Transition (EMT), and the corresponding reverse process, Mesenchymal-Epithelial Transition (MET), are dynamic and reversible cellular programs orchestrated by many changes at biochemical and morphological levels.
In this review, we first discuss recent efforts combining theoretical and experimental approaches to elucidate mechanisms underlying EMT multi-stability (i. e. the existence of multiple stable phenotypes during EMT) and the properties of hybrid E/M phenotypes.