no code implementations • 11 Oct 2021 • Anish A. Sarma, Jing Shuang Li, Josefin Stenberg, Gwyneth Card, Elizabeth S. Heckscher, Narayanan Kasthuri, Terrence Sejnowski, John C. Doyle
In biology, in addition to typical feedback between plant and controller, we observe feedback pathways within control systems, which we call internal feedback pathways (IFPs), that are often very complex.
1 code implementation • 12 Jul 2021 • Donglai Wei, Kisuk Lee, Hanyu Li, Ran Lu, J. Alexander Bae, Zequan Liu, Lifu Zhang, Márcia dos Santos, Zudi Lin, Thomas Uram, Xueying Wang, Ignacio Arganda-Carreras, Brian Matejek, Narayanan Kasthuri, Jeff Lichtman, Hanspeter Pfister
Electron microscopy (EM) enables the reconstruction of neural circuits at the level of individual synapses, which has been transformative for scientific discoveries.
1 code implementation • 11 Jul 2020 • Viktor Nikitin, Vincent De Andrade, Azat Slyamov, Benjamin J. Gould, Yuepeng Zhang, Vandana Sampathkumar, Narayanan Kasthuri, Doga Gursoy, Francesco De Carlo
Resolution level and reconstruction quality in nano-computed tomography (nano-CT) are in part limited by the stability of microscopes, because the magnitude of mechanical vibrations during scanning becomes comparable to the imaging resolution, and the ability of the samples to resist beam damage during data acquisition.
1 code implementation • 13 May 2019 • Wushi Dong, Murat Keceli, Rafael Vescovi, Hanyu Li, Corey Adams, Elise Jennings, Samuel Flender, Tom Uram, Venkatram Vishwanath, Nicola Ferrier, Narayanan Kasthuri, Peter Littlewood
Mapping all the neurons in the brain requires automatic reconstruction of entire cells from volume electron microscopy data.
no code implementations • 21 Nov 2016 • Seymour Knowles-Barley, Verena Kaynig, Thouis Ray Jones, Alyssa Wilson, Joshua Morgan, Dongil Lee, Daniel Berger, Narayanan Kasthuri, Jeff W. Lichtman, Hanspeter Pfister
The best segmentation results obtained gave $V^\text{Info}_\text{F-score}$ scores of 0. 9054 and 09182 for the cortex datasets, 0. 9438 for LGN, and 0. 9150 for Cerebellum.
no code implementations • 13 Apr 2016 • Eva L. Dyer, William Gray Roncal, Hugo L. Fernandes, Doga Gürsoy, Vincent De Andrade, Rafael Vescovi, Kamel Fezzaa, Xianghui Xiao, Joshua T. Vogelstein, Chris Jacobsen, Konrad P. Körding, Narayanan Kasthuri
Methods for resolving the 3D microstructure of the brain typically start by thinly slicing and staining the brain, and then imaging each individual section with visible light photons or electrons.
no code implementations • 16 Apr 2014 • Ayushi Sinha, William Gray Roncal, Narayanan Kasthuri, Jeff W. Lichtman, Randal Burns, Michael Kazhdan
Accurately estimating the wiring diagram of a brain, known as a connectome, at an ultrastructure level is an open research problem.
no code implementations • 16 Apr 2014 • Ayushi Sinha, William Gray Roncal, Narayanan Kasthuri, Ming Chuang, Priya Manavalan, Dean M. Kleissas, Joshua T. Vogelstein, R. Jacob Vogelstein, Randal Burns, Jeff W. Lichtman, Michael Kazhdan
The contribution of this work is the introduction of a straightforward and robust pipeline which annotates axoplasmic reticula with high precision, contributing towards advancements in automatic feature annotations in neural EM data.
no code implementations • 28 Mar 2013 • Verena Kaynig, Amelio Vazquez-Reina, Seymour Knowles-Barley, Mike Roberts, Thouis R. Jones, Narayanan Kasthuri, Eric Miller, Jeff Lichtman, Hanspeter Pfister
Segmentation of large-scale electron microscopy data is the main bottleneck in the analysis of these data sets.