The detection of mitotic figures from different scanners/sites remains an important topic of research, owing to its potential in assisting clinicians with tumour grading.
From the simple measurement of tissue attributes in pathology workflow to designing an explainable diagnostic/prognostic AI tool, access to accurate semantic segmentation of tissue regions in histology images is a prerequisite.
no code implementations • 25 Aug 2021 • Simon Graham, Mostafa Jahanifar, Ayesha Azam, Mohammed Nimir, Yee-Wah Tsang, Katherine Dodd, Emily Hero, Harvir Sahota, Atisha Tank, Ksenija Benes, Noorul Wahab, Fayyaz Minhas, Shan E Ahmed Raza, Hesham El Daly, Kishore Gopalakrishnan, David Snead, Nasir Rajpoot
The development of deep segmentation models for computational pathology (CPath) can help foster the investigation of interpretable morphological biomarkers.
To tackle these challenges, we propose to use a statistical network analysis method to describe the complex structure of the tissue micro-environment by modelling nuclei and their connections as a network.
no code implementations • 25 Jun 2021 • Noorul Wahab, Islam M Miligy, Katherine Dodd, Harvir Sahota, Michael Toss, Wenqi Lu, Mostafa Jahanifar, Mohsin Bilal, Simon Graham, Young Park, Giorgos Hadjigeorghiou, Abhir Bhalerao, Ayat Lashen, Asmaa Ibrahim, Ayaka Katayama, Henry O Ebili, Matthew Parkin, Tom Sorell, Shan E Ahmed Raza, Emily Hero, Hesham Eldaly, Yee Wah Tsang, Kishore Gopalakrishnan, David Snead, Emad Rakha, Nasir Rajpoot, Fayyaz Minhas
The analyses reported in this work highlight best practice recommendations that can be used as annotation guidelines over the lifecycle of a CPath project.
Deep learning models are routinely employed in computational pathology (CPath) for solving problems of diagnostic and prognostic significance.
no code implementations • 16 Apr 2021 • Muhammad Shaban, Shan E Ahmed Raza, Mariam Hassan, Arif Jamshed, Sajid Mushtaq, Asif Loya, Nikolaos Batis, Jill Brooks, Paul Nankivell, Neil Sharma, Max Robinson, Hisham Mehanna, Syed Ali Khurram, Nasir Rajpoot
In this study, our aim is to explore the prognostic significance of tumour-associated stroma infiltrating lymphocytes (TASILs) in head and neck squamous cell carcinoma (HNSCC) through an AI based automated method.
In this paper, we propose a deep dictionary learning approach to solve the problem of tissue phenotyping in histology images.
We present ARCH, a computational pathology (CP) multiple instance captioning dataset to facilitate dense supervision of CP tasks.
In this worldwide spread of SARS-CoV-2 (COVID-19) infection, it is of utmost importance to detect the disease at an early stage especially in the hot spots of this epidemic.
In this paper, we propose a self-supervised CNN approach to leverage unlabeled data for learning generalizable and domain invariant representations in pathology images.
Compared to other existing approaches, our framework is efficient in terms of the memory requirements for training and also in terms of the number of computations to construct a large high-resolution image.
As nuclei, cells and glands are fundamental objects for downstream analysis in computational pathology/cytology, in this paper we propose a simple CNN-based approach to speed up collecting annotations for these objects which requires minimum interaction from the annotator.
In this work we show preliminary results of deep multi-task learning in the area of computational pathology.
Histology images are inherently symmetric under rotation, where each orientation is equally as likely to appear.
Ranked #1 on Colorectal Gland Segmentation: on CRAG
The emerging area of computational pathology (CPath) is ripe ground for the application of deep learning (DL) methods to healthcare due to the sheer volume of raw pixel data in whole-slide images (WSIs) of cancerous tissue slides.
To train a robust deep learning model, one usually needs a balanced set of categories in the training data.
Best performing nuclear segmentation methods are based on deep learning algorithms that require a large amount of annotated data.
Furthermore, to deal with redundancy in the graph, we propose a sampling technique that removes nodes in areas of dense nuclear activity.
Spectral clustering method is applied on the output of the last SpaNet, which utilizes the nuclear mask and the Gaussian-like detection map for determining the connected components and associated cluster identifiers, respectively.
Nuclear segmentation and classification within Haematoxylin & Eosin stained histology images is a fundamental prerequisite in the digital pathology work-flow.
Ranked #1 on Multi-tissue Nucleus Segmentation on Kumar
no code implementations • 31 Oct 2018 • Quoc Dang Vu, Simon Graham, Minh Nguyen Nhat To, Muhammad Shaban, Talha Qaiser, Navid Alemi Koohbanani, Syed Ali Khurram, Tahsin Kurc, Keyvan Farahani, Tianhao Zhao, Rajarsi Gupta, Jin Tae Kwak, Nasir Rajpoot, Joel Saltz
Segmentation of nuclei and classification of tissue images are two common tasks in tissue image analysis.
Computer-aided diagnosis systems for classification of different type of skin lesions have been an active field of research in recent decades.
Nuclei detection is an important task in the histology domain as it is a main step toward further analysis such as cell counting, cell segmentation, study of cell connections, etc.
With multiple crowd gatherings of millions of people every year in events ranging from pilgrimages to protests, concerts to marathons, and festivals to funerals; visual crowd analysis is emerging as a new frontier in computer vision.
Ranked #6 on Crowd Counting on UCF-QNRF
In this paper, we present a semi-supervised mitosis detection method which is designed to leverage a large number of unlabeled breast cancer WSIs.
no code implementations • 22 Jul 2018 • Mitko Veta, Yujing J. Heng, Nikolas Stathonikos, Babak Ehteshami Bejnordi, Francisco Beca, Thomas Wollmann, Karl Rohr, Manan A. Shah, Dayong Wang, Mikael Rousson, Martin Hedlund, David Tellez, Francesco Ciompi, Erwan Zerhouni, David Lanyi, Matheus Viana, Vassili Kovalev, Vitali Liauchuk, Hady Ahmady Phoulady, Talha Qaiser, Simon Graham, Nasir Rajpoot, Erik Sjöblom, Jesper Molin, Kyunghyun Paeng, Sangheum Hwang, Sunggyun Park, Zhipeng Jia, Eric I-Chao Chang, Yan Xu, Andrew H. Beck, Paul J. van Diest, Josien P. W. Pluim
The best performing automatic method for the first task achieved a quadratic-weighted Cohen's kappa score of $\kappa$ = 0. 567, 95% CI [0. 464, 0. 671] between the predicted scores and the ground truth.
no code implementations • 6 Jun 2018 • Lena Maier-Hein, Matthias Eisenmann, Annika Reinke, Sinan Onogur, Marko Stankovic, Patrick Scholz, Tal Arbel, Hrvoje Bogunovic, Andrew P. Bradley, Aaron Carass, Carolin Feldmann, Alejandro F. Frangi, Peter M. Full, Bram van Ginneken, Allan Hanbury, Katrin Honauer, Michal Kozubek, Bennett A. Landman, Keno März, Oskar Maier, Klaus Maier-Hein, Bjoern H. Menze, Henning Müller, Peter F. Neher, Wiro Niessen, Nasir Rajpoot, Gregory C. Sharp, Korsuk Sirinukunwattana, Stefanie Speidel, Christian Stock, Danail Stoyanov, Abdel Aziz Taha, Fons van der Sommen, Ching-Wei Wang, Marc-André Weber, Guoyan Zheng, Pierre Jannin, Annette Kopp-Schneider
International challenges have become the standard for validation of biomedical image analysis methods.
However, this task is non-trivial due to the large variability in glandular appearance and the difficulty in differentiating between certain glandular and non-glandular histological structures.
Ranked #3 on Colorectal Gland Segmentation: on CRAG
In this work, we propose a tumor segmentation framework based on the novel concept of persistent homology profiles (PHPs).
Convolutional neural networks (CNNs) have been recently used for a variety of histology image analysis.
Distant metastasis is the major cause of death in colorectal cancer (CRC).
no code implementations • 23 May 2017 • Talha Qaiser, Abhik Mukherjee, Chaitanya Reddy Pb, Sai Dileep Munugoti, Vamsi Tallam, Tomi Pitkäaho, Taina Lehtimäki, Thomas Naughton, Matt Berseth, Aníbal Pedraza, Ramakrishnan Mukundan, Matthew Smith, Abhir Bhalerao, Erik Rodner, Marcel Simon, Joachim Denzler, Chao-Hui Huang, Gloria Bueno, David Snead, Ian Ellis, Mohammad Ilyas, Nasir Rajpoot
In this paper, we report on a recent automated Her2 scoring contest, held in conjunction with the annual PathSoc meeting held in Nottingham in June 2016, aimed at systematically comparing and advancing the state-of-the-art Artificial Intelligence (AI) based automated methods for Her2 scoring.