1 code implementation • 1 Jun 2014 • Nikolai Slavov
Networks are a unifying framework for modeling complex systems and network inference problems are frequently encountered in many fields.
2 code implementations • 1 Jun 2014 • Dmitry Malioutov, Nikolai Slavov
The special case when all dependent and independent variables have the same level of uncorrelated Gaussian noise, known as ordinary TLS, can be solved by singular value decomposition (SVD).
no code implementations • 5 Aug 2017 • Dmitry Malioutov, Tianchi Chen, Jacob Jaffe, Edoardo Airoldi, Steven Carr, Bogdan Budnik, Nikolai Slavov
Many proteoforms - arising from alternative splicing, post-translational modifications (PTMs), or paralogous genes - have distinct biological functions, such as histone PTM proteoforms.
no code implementations • 11 Jul 2020 • Aleksandra A. Petelski, Nikolai Slavov
regulation largely unexplored, in part due to methodological limitations.
no code implementations • 17 Aug 2021 • Participants in a NIH Workshop on Functional, Integrative Proteomics, :, Kristin E. Burnum Johnson, Thomas P. Conrads, Richard R. Drake, Amy E. Herr, Ravi Iyengar, Ryan T. Kelly, Emma Lundberg, Michael J. MacCoss, Alexandra Naba, Garry P. Nolan, Pavel A. Pevzner, Karin D. Rodland, Salvatore Sechi, Nikolai Slavov, Jeffrey M. Spraggins, Jennifer E. Van Eyk, Marc Vidal, Christine Vogel, David R. Walt, Neil L. Kelleher
All human diseases involve proteins, yet our current tools to characterize and quantify them are limited.
1 code implementation • 19 Jul 2022 • Laurent Gatto, Ruedi Aebersold, Juergen Cox, Vadim Demichev, Jason Derks, Edward Emmott, Alexander M. Franks, Alexander R. Ivanov, Ryan T. Kelly, Luke Khoury, Andrew Leduc, Michael J. MacCoss, Peter Nemes, David H. Perlman, Aleksandra A. Petelski, Christopher M. Rose, Erwin M. Schoof, Jennifer Van Eyk, Christophe Vanderaa, John R. Yates III, Nikolai Slavov
Analyzing proteins from single cells by tandem mass spectrometry (MS) has become technically feasible.
no code implementations • 31 Jul 2022 • Michael J. MacCoss, Javier Alfaro, Meni Wanunu, Danielle A. Faivre, Nikolai Slavov
Mammalian cells have about 30, 000-fold more protein molecules than mRNA molecules.
no code implementations • 14 Aug 2023 • Andrew Leduc, Hannah Harens, Nikolai Slavov
Biological functions stem from coordinated interactions among proteins, nucleic acids and small molecules.