no code implementations • 7 Nov 2024 • Billy C. Smith, Christopher Thornton, Rachel E. Stirling, Guillermo M. Besne, Nathan Evans, Peter N. Taylor, Philippa J. Karoly, Yujiang Wang
Interpretation: This finding indicates that the circadian rhythm of heart rate is more variable for people with epilepsy and that this can be detected using a wearable device.
no code implementations • 17 Oct 2024 • Sarah J. Gascoigne, Manel Vila-Vidal, Nathan Evans, Anderson Brito Da Silva, Rhys H. Thomas, Christopher Thornton, Kevin Wilson, Peter N. Taylor, Adrià Tauste, Yujiang Wang
Therefore, we investigated the effect of three key methodological differences (or Decision Points).
no code implementations • 3 Sep 2024 • Nathan Evans, Sarah J. Gascoigne, Guillermo M. Besne, Chris Thornton, Gabrielle M. Schroeder, Fahmida A Chowdhury, Beate Diehl, John S Duncan, Andrew W McEvoy, Anna Miserocchi, Jane de Tisi, Peter N. Taylor, Yujiang Wang
Our objective was to test if this effect was due to limiting seizure spread through early termination of otherwise unchanged seizures.
no code implementations • 11 Aug 2024 • Jonathan Horsley, Yujiang Wang, Callum Simpson, Vyte Janiukstyte, Karoline Leiberg, Beth Little, Jane de Tisi, John Duncan, Peter N. Taylor
Individuals with TLE and SE had reduced entorhinal thickness compared to those with TLE and no history of SE.
no code implementations • 10 Jun 2024 • Peter N. Taylor, Yujiang Wang, Callum Simpson, Vytene Janiukstyte, Jonathan Horsley, Karoline Leiberg, Beth Little, Harry Clifford, Sophie Adler, Sjoerd B. Vos, Gavin P Winston, Andrew W McEvoy, Anna Miserocchi, Jane de Tisi, John S Duncan
To demonstrate the veracity of our data, we successfully replicated previous studies showing long-term outcomes of seizure freedom in the range of around 50%.
1 code implementation • 4 Jun 2024 • John F. Ingham, Frances Hutchings, Paolo Zuliani, Yujiang Wang, Sadegh Soudjani, Peter N. Taylor
Vagus Nerve Stimulation (VNS) is an established palliative treatment for drug resistant epilepsy.
1 code implementation • 2 May 2024 • Guillermo M. Besne, Nathan Evans, Mariella Panagiotopoulou, Billy Smith, Fahmida A Chowdhury, Beate Diehl, John S Duncan, Andrew W McEvoy, Anna Miserocchi, Jane de Tisi, Mathew Walker, Peter N. Taylor, Chris Thornton, Yujiang Wang
Anti-seizure medications (ASMs) are the primary treatment for epilepsy, yet medication tapering effects have not been investigated in a dose, region, and time-dependent manner, despite their potential impact on research and clinical practice.
no code implementations • 27 Apr 2024 • Heather Woodhouse, Gerard Hall, Callum Simpson, Csaba Kozma, Frances Turner, Gabrielle M. Schroeder, Beate Diehl, John S. Duncan, Jiajie Mo, Kai Zhang, Aswin Chari, Martin Tisdall, Friederike Moeller, Chris Petkov, Matthew A. Howard, George M. Ibrahim, Elizabeth Donner, Nebras M. Warsi, Raheel Ahmed, Peter N. Taylor, Yujiang Wang
Results: Recording hospital significantly impacted normative icEEG maps in all frequency bands, and age was a more influential predictor of band power than sex.
no code implementations • 16 Apr 2024 • Vytene Janiukstyte, Csaba Kozma, Thomas W. Owen, Umair J Chaudhury, Beate Diehl, Louis Lemieux, John S Duncan, Fergus Rugg-Gunn, Jane de Tisi, Yujiang Wang, Peter N. Taylor
Alpha slowing in TLE was found in both EEG and MEG recordings.
no code implementations • 24 Nov 2023 • Sarah J. Gascoigne, Nathan Evans, Gerard Hall, Csaba Kozma, Mariella Panagiotopoulou, Gabrielle M. Schroeder, Callum Simpson, Christopher Thornton, Frances Turner, Heather Woodhouse, Jess Blickwedel, Fahmida Chowdhury, Beate Diehl, John S. Duncan, Ryan Faulder, Rhys H. Thomas, Kevin Wilson, Peter N. Taylor, Yujiang Wang
Retrospective analysis of icEEG recordings from 63 subjects (735 seizures) identified seizure onset regions through visual inspection and algorithmic delineation.
no code implementations • 22 Nov 2023 • Karoline Leiberg, Timo Blattner, Bethany Little, Victor B. B. Mello, Fernanda H. P. de Moraes, Christian Rummel, Peter N. Taylor, Bruno Mota, Yujiang Wang
Most studies to date have found a monotonic decrease in commonly used morphometrics, such as cortical thickness and volume, across the entire brain with increasing age.
no code implementations • 10 Oct 2023 • Csaba Kozma, Gabrielle Schroeder, Tom Owen, Jane de Tisi, Andrew W. McEvoy, Anna Miserocchi, John Duncan, Yujiang Wang, Peter N. Taylor
Combining periodic and aperiodic abnormalities improved performance, similar to the complete band power approach.
no code implementations • 11 Apr 2023 • Thomas W. Owen, Vytene Janiukstyte, Gerard R. Hall, Jonathan J. Horsley, Andrew McEvoy, Anna Miserocchi, Jane de Tisi, John S. Duncan, Fergus Rugg-Gunn, Yujiang Wang, Peter N. Taylor
We quantified the spatial overlap between the abnormality cluster and subsequent resection, hypothesising a greater overlap in seizure-free patients.
no code implementations • 11 Apr 2023 • Thomas W. Owen, Vytene Janiukstyte, Gerard R. Hall, Fahmida A. Chowdhury, Beate Diehl, Andrew McEvoy, Anna Miserocchi, Jane de Tisi, John S. Duncan, Fergus Rugg-Gunn, Yujiang Wang, Peter N. Taylor
Finally, we assessed if the implantation of electrodes in abnormal tissue, and resection of the strongest abnormalities determined by MEG and iEEG explained surgical outcome.
1 code implementation • 16 Sep 2022 • Yujiang Wang, Karoline Leiberg, Nathan Kindred, Christopher R. Madan, Colline Poirier, Christopher I. Petkov, Peter N. Taylor, Bruno C. C. Mota
To demonstrate the importance of this new understanding, we show a scale-dependent effect of ageing on brain morphology.
no code implementations • 13 Jul 2022 • Thomas W. Owen, Gabrielle M. Schroeder, Vytene Janiukstyte, Gerard R. Hall, Andrew McEvoy, Anna Miserocchi, Jane de Tisi, John S. Duncan, Fergus Rugg-Gunn, Yujiang Wang, Peter N. Taylor
Resting-state MEG data were acquired for 70 healthy controls and 32 patients with refractory neocortical epilepsy.
1 code implementation • 30 Jun 2022 • Sarah J. Gascoigne, Leonard Waldmann, Mariella Panagiotopoulou, Fahmida Chowdhury, Alison Cronie, Beate Diehl, John S. Duncan, Jennifer Falconer, Yu Guan, Veronica Leach, Shona Livingstone, Christoforos Papasavvas, Ryan Faulder, Jess Blickwedel, Gabrielle M. Schroeder, Rhys H. Thomas, Kevin Wilson, Peter N. Taylor, Yujiang Wang
In individual patients, 71% had a moderate to large difference (ranksum r > 0. 3) between focal and subclinical seizures in three or more markers.
no code implementations • 17 Apr 2022 • Nishant Sinha, John S. Duncan, Beate Diehl, Fahmida A. Chowdhury, Jane de Tisi, Anna Miserocchi, Andrew W. McEvoy, Kathryn A. Davis, Sjoerd B. Vos, Gavin P. Winston, Yujiang Wang, Peter N. Taylor
We investigated pre-operative structure-function coupling at two spatial scales a) at the global iEEG network level and b) at the resolution of individual iEEG electrode contacts using virtual surgeries.
no code implementations • 5 Feb 2022 • Jonathan J. Horsley, Gabrielle M. Schroeder, Rhys H. Thomas, Jane de Tisi, Sjoerd B. Vos, Gavin P. Winston, John S. Duncan, Yujiang Wang, Peter N. Taylor
We computed grey matter volumetric changes and white matter structural connectivity abnormalities in 144 patients with unilateral TLE and 96 healthy controls.
no code implementations • 27 Jan 2022 • Gabrielle M. Schroeder, Philippa J. Karoly, Matias Maturana, Mariella Panagiotopoulou, Peter N. Taylor, Mark J. Cook, Yujiang Wang
We then compared SNS occurrence and duration to (1) time since implantation and (2) patient-specific circadian and multidien cycles in interictal spike rate.
no code implementations • 14 Sep 2021 • Gabrielle M. Schroeder, Fahmida A. Chowdhury, Mark J. Cook, Beate Diehl, John S. Duncan, Philippa J. Karoly, Peter N. Taylor, Yujiang Wang
However, it is unclear whether seizures following the same pathway will have the same duration or if these features can vary independently.