no code implementations • 10 Feb 2018 • Scott Gigante, David van Dijk, Kevin Moon, Alexander Strzalkowski, Guy Wolf, Smita Krishnaswamy
In order to model the dynamics of such systems given snapshot data, or local transitions, we present a deep neural network framework we call Dynamics Modeling Network or DyMoN.
no code implementations • 27 Sep 2018 • Scott Gigante, David van Dijk, Kevin R. Moon, Alexander Strzalkowski, Katie Ferguson, Guy Wolf, Smita Krishnaswamy
DyMoN is well-suited to the idiosyncrasies of biological data, including noise, sparsity, and the lack of longitudinal measurements in many types of systems.
no code implementations • 30 Sep 2018 • Jay S. Stanley III, Scott Gigante, Guy Wolf, Smita Krishnaswamy
We use this to relate the diffusion coordinates of each dataset through our assumption of partial feature correspondence.
no code implementations • 31 Jan 2019 • Scott Gigante, Jay S. Stanley III, Ngan Vu, David van Dijk, Kevin Moon, Guy Wolf, Smita Krishnaswamy
Diffusion maps are a commonly used kernel-based method for manifold learning, which can reveal intrinsic structures in data and embed them in low dimensions.
1 code implementation • NeurIPS 2019 • Scott Gigante, Adam S. Charles, Smita Krishnaswamy, Gal Mishne
We demonstrate M-PHATE with two vignettes: continual learning and generalization.
no code implementations • 14 May 2022 • Scott Gigante, Varsha G. Raghavan, Amanda M. Robinson, Robert A. Barton, Adeeb H. Rahman, Drausin F. Wulsin, Jacques Banchereau, Noam Solomon, Luis F. Voloch, Fabian J. Theis
Translating the relevance of preclinical models ($\textit{in vitro}$, animal models, or organoids) to their relevance in humans presents an important challenge during drug development.