1 code implementation • 3 May 2024 • Abdullah Alsalemi, Anza Shakeel, Mollie Clark, Syed Ali Khurram, Shan E Ahmed Raza
Early detection of cancer can help improve patient prognosis by early intervention.
no code implementations • 25 Apr 2024 • Adith Jeyasangar, Abdullah Alsalemi, Shan E Ahmed Raza
Whole Slide Images (WSIs) provide exceptional detail for studying tissue architecture at the cell level.
no code implementations • 29 Feb 2024 • Quoc Dang Vu, Caroline Fong, Anderley Gordon, Tom Lund, Tatiany L Silveira, Daniel Rodrigues, Katharina von Loga, Shan E Ahmed Raza, David Cunningham, Nasir Rajpoot
Gastric and oesophageal (OG) cancers are the leading causes of cancer mortality worldwide.
no code implementations • 27 Nov 2023 • Arwa Al-Rubaian, Gozde N. Gunesli, Wajd A. Althakfi, Ayesha Azam, Nasir Rajpoot, Shan E Ahmed Raza
Lung adenocarcinoma is a morphologically heterogeneous disease, characterized by five primary histologic growth patterns.
1 code implementation • 10 Nov 2023 • Adam J Shephard, Mostafa Jahanifar, Ruoyu Wang, Muhammad Dawood, Simon Graham, Kastytis Sidlauskas, Syed Ali Khurram, Nasir M Rajpoot, Shan E Ahmed Raza
Tumour-infiltrating lymphocytes (TILs) are considered as a valuable prognostic markers in both triple-negative and human epidermal growth factor receptor 2 (HER2) positive breast cancer.
no code implementations • 9 Nov 2023 • Adam J Shephard, Hanya Mahmood, Shan E Ahmed Raza, Anna Luiza Damaceno Araujo, Alan Roger Santos-Silva, Marcio Ajudarte Lopes, Pablo Agustin Vargas, Kris McCombe, Stephanie Craig, Jacqueline James, Jill Brooks, Paul Nankivell, Hisham Mehanna, Syed Ali Khurram, Nasir M Rajpoot
Oral epithelial dysplasia (OED) is a premalignant histopathological diagnosis given to lesions of the oral cavity.
no code implementations • 30 Oct 2023 • Mostafa Jahanifar, Manahil Raza, Kesi Xu, Trinh Vuong, Rob Jewsbury, Adam Shephard, Neda Zamanitajeddin, Jin Tae Kwak, Shan E Ahmed Raza, Fayyaz Minhas, Nasir Rajpoot
Deep learning models have exhibited exceptional effectiveness in Computational Pathology (CPath) by tackling intricate tasks across an array of histology image analysis applications.
no code implementations • 6 Jul 2023 • Adam J Shephard, Raja Muhammad Saad Bashir, Hanya Mahmood, Mostafa Jahanifar, Fayyaz Minhas, Shan E Ahmed Raza, Kris D McCombe, Stephanie G Craig, Jacqueline James, Jill Brooks, Paul Nankivell, Hisham Mehanna, Syed Ali Khurram, Nasir M Rajpoot
To address this, we developed a novel artificial intelligence algorithm that can assign an Oral Malignant Transformation (OMT) risk score, based on histological patterns in the in Haematoxylin and Eosin stained whole slide images, to quantify the risk of OED progression.
1 code implementation • 11 Mar 2023 • Simon Graham, Quoc Dang Vu, Mostafa Jahanifar, Martin Weigert, Uwe Schmidt, Wenhua Zhang, Jun Zhang, Sen yang, Jinxi Xiang, Xiyue Wang, Josef Lorenz Rumberger, Elias Baumann, Peter Hirsch, Lihao Liu, Chenyang Hong, Angelica I. Aviles-Rivero, Ayushi Jain, Heeyoung Ahn, Yiyu Hong, Hussam Azzuni, Min Xu, Mohammad Yaqub, Marie-Claire Blache, Benoît Piégu, Bertrand Vernay, Tim Scherr, Moritz Böhland, Katharina Löffler, Jiachen Li, Weiqin Ying, Chixin Wang, Dagmar Kainmueller, Carola-Bibiane Schönlieb, Shuolin Liu, Dhairya Talsania, Yughender Meda, Prakash Mishra, Muhammad Ridzuan, Oliver Neumann, Marcel P. Schilling, Markus Reischl, Ralf Mikut, Banban Huang, Hsiang-Chin Chien, Ching-Ping Wang, Chia-Yen Lee, Hong-Kun Lin, Zaiyi Liu, Xipeng Pan, Chu Han, Jijun Cheng, Muhammad Dawood, Srijay Deshpande, Raja Muhammad Saad Bashir, Adam Shephard, Pedro Costa, João D. Nunes, Aurélio Campilho, Jaime S. Cardoso, Hrishikesh P S, Densen Puthussery, Devika R G, Jiji C V, Ye Zhang, Zijie Fang, Zhifan Lin, Yongbing Zhang, Chunhui Lin, Liukun Zhang, Lijian Mao, Min Wu, Vi Thi-Tuong Vo, Soo-Hyung Kim, Taebum Lee, Satoshi Kondo, Satoshi Kasai, Pranay Dumbhare, Vedant Phuse, Yash Dubey, Ankush Jamthikar, Trinh Thi Le Vuong, Jin Tae Kwak, Dorsa Ziaei, Hyun Jung, Tianyi Miao, David Snead, Shan E Ahmed Raza, Fayyaz Minhas, Nasir M. Rajpoot
Nuclear detection, segmentation and morphometric profiling are essential in helping us further understand the relationship between histology and patient outcome.
no code implementations • 30 Jan 2023 • Raja Muhammad Saad Bashir, Talha Qaiser, Shan E Ahmed Raza, Nasir M. Rajpoot
The proposed method incorporates context-aware consistency by contrasting pairs of overlapping images in a pixel-wise manner from changing contexts resulting in robust and context invariant features.
no code implementations • 16 Jan 2023 • Yiping Jiao, Jeroen van der Laak, Shadi Albarqouni, Zhang Li, Tao Tan, Abhir Bhalerao, Jiabo Ma, Jiamei Sun, Johnathan Pocock, Josien P. W. Pluim, Navid Alemi Koohbanani, Raja Muhammad Saad Bashir, Shan E Ahmed Raza, Sibo Liu, Simon Graham, Suzanne Wetstein, Syed Ali Khurram, Thomas Watson, Nasir Rajpoot, Mitko Veta, Francesco Ciompi
Additionally, we present post-competition results where we show how the presented methods perform on an independent set of lung cancer slides, which was not part of the initial competition, as well as a comparison on lymphocyte assessment between presented methods and a panel of pathologists.
no code implementations • 9 Jan 2023 • Quoc Dang Vu, Robert Jewsbury, Simon Graham, Mostafa Jahanifar, Shan E Ahmed Raza, Fayyaz Minhas, Abhir Bhalerao, Nasir Rajpoot
Since the introduction of digital and computational pathology as a field, one of the major problems in the clinical application of algorithms has been the struggle to generalize well to examples outside the distribution of the training data.
no code implementations • 26 Aug 2022 • Mostafa Jahanifar, Adam Shephard, Neda Zamanitajeddin, Simon Graham, Shan E Ahmed Raza, Fayyaz Minhas, Nasir Rajpoot
Counting of mitotic figures is a fundamental step in grading and prognostication of several cancers.
1 code implementation • 23 Jun 2022 • Adam Shephard, Mostafa Jahanifar, Ruoyu Wang, Muhammad Dawood, Simon Graham, Kastytis Sidlauskas, Syed Ali Khurram, Nasir Rajpoot, Shan E Ahmed Raza
The Tumor InfiltratinG lymphocytes in breast cancER (TiGER) challenge, aims to assess the prognostic significance of computer-generated TILs scores for predicting survival as part of a Cox proportional hazards model.
1 code implementation • 28 Feb 2022 • Simon Graham, Quoc Dang Vu, Mostafa Jahanifar, Shan E Ahmed Raza, Fayyaz Minhas, David Snead, Nasir Rajpoot
In this paper, we present a multi-task learning approach for segmentation and classification of nuclei, glands, lumina and different tissue regions that leverages data from multiple independent data sources.
no code implementations • 24 Feb 2022 • Ruqayya Awan, Mohammed Nimir, Shan E Ahmed Raza, Mohsin Bilal, Johannes Lotz, David Snead, Andrew Robinson, Nasir Rajpoot
Unlike previous studies on MSI prediction involving training a CNN using coarse labels (MSI vs Microsatellite Stable (MSS)), we have utilised fine-grain MMR labels for training purposes.
no code implementations • 21 Feb 2022 • Ruqayya Awan, Shan E Ahmed Raza, Johannes Lotz, Nick Weiss, Nasir Rajpoot
During the slide preparation, a tissue section may be placed at an arbitrary orientation as compared to other sections of the same tissue block.
1 code implementation • 14 Feb 2022 • Quoc Dang Vu, Kashif Rajpoot, Shan E Ahmed Raza, Nasir Rajpoot
Based on our experiments involving various datasets consisting of a total of 5, 306 WSIs, the results demonstrate that H2T based holistic WSI-level representations offer competitive performance compared to recent state-of-the-art methods and can be readily utilized for various downstream analysis tasks.
no code implementations • 29 Nov 2021 • Simon Graham, Mostafa Jahanifar, Quoc Dang Vu, Giorgos Hadjigeorghiou, Thomas Leech, David Snead, Shan E Ahmed Raza, Fayyaz Minhas, Nasir Rajpoot
The challenge encourages researchers to develop algorithms that perform segmentation, classification and counting of nuclei within the current largest known publicly available nuclei-level dataset in CPath, containing around half a million labelled nuclei.
no code implementations • 25 Nov 2021 • Gozde N. Gunesli, Mohsin Bilal, Shan E Ahmed Raza, Nasir M. Rajpoot
In this study, we propose FedDropoutAvg, a new federated learning approach for training a generalizable model.
no code implementations • 25 Aug 2021 • Simon Graham, Mostafa Jahanifar, Ayesha Azam, Mohammed Nimir, Yee-Wah Tsang, Katherine Dodd, Emily Hero, Harvir Sahota, Atisha Tank, Ksenija Benes, Noorul Wahab, Fayyaz Minhas, Shan E Ahmed Raza, Hesham El Daly, Kishore Gopalakrishnan, David Snead, Nasir Rajpoot
The development of deep segmentation models for computational pathology (CPath) can help foster the investigation of interpretable morphological biomarkers.
no code implementations • MICCAI Workshop COMPAY 2021 • Hammam Alghamdi, Navid Alemi Koohbanani, Nasir Rajpoot, Shan E Ahmed Raza
Digital pathology opens new pathways for computational algorithms to play a significant role in the prognosis, diagnosis, and analysis of cancer.
no code implementations • 25 Jun 2021 • Noorul Wahab, Islam M Miligy, Katherine Dodd, Harvir Sahota, Michael Toss, Wenqi Lu, Mostafa Jahanifar, Mohsin Bilal, Simon Graham, Young Park, Giorgos Hadjigeorghiou, Abhir Bhalerao, Ayat Lashen, Asmaa Ibrahim, Ayaka Katayama, Henry O Ebili, Matthew Parkin, Tom Sorell, Shan E Ahmed Raza, Emily Hero, Hesham Eldaly, Yee Wah Tsang, Kishore Gopalakrishnan, David Snead, Emad Rakha, Nasir Rajpoot, Fayyaz Minhas
The analyses reported in this work highlight best practice recommendations that can be used as annotation guidelines over the lifecycle of a CPath project.
no code implementations • 16 Apr 2021 • Muhammad Shaban, Shan E Ahmed Raza, Mariam Hassan, Arif Jamshed, Sajid Mushtaq, Asif Loya, Nikolaos Batis, Jill Brooks, Paul Nankivell, Neil Sharma, Max Robinson, Hisham Mehanna, Syed Ali Khurram, Nasir Rajpoot
In this study, our aim is to explore the prognostic significance of tumour-associated stroma infiltrating lymphocytes (TASILs) in head and neck squamous cell carcinoma (HNSCC) through an AI based automated method.
no code implementations • 11 Aug 2020 • R. M. Saad Bashir, Talha Qaiser, Shan E Ahmed Raza, Nasir M. Rajpoot
The model is trained in multi-task learning manner with noise tolerant joint loss for classification localization and achieves better performance when given limited data in contrast to a simple deep model.
4 code implementations • 16 Dec 2018 • Simon Graham, Quoc Dang Vu, Shan E Ahmed Raza, Ayesha Azam, Yee Wah Tsang, Jin Tae Kwak, Nasir Rajpoot
Nuclear segmentation and classification within Haematoxylin & Eosin stained histology images is a fundamental prerequisite in the digital pathology work-flow.
Ranked #2 on Multi-tissue Nucleus Segmentation on CoNSeP
no code implementations • 28 Jun 2018 • Priya Lakshmi Narayanan, Shan E Ahmed Raza, Andrew Dodson, Barry Gusterson, Mitchell Dowsett, Yinyin Yuan
Subsequently, seeds generated from cell segmentation were propagated to a spatially constrained convolutional neural network for the classification of the cells into stromal, lymphocyte, Ki67-positive cancer cell, and Ki67-negative cancer cell.
no code implementations • 18 Jun 2018 • Shan E Ahmed Raza, Khalid AbdulJabbar, Mariam Jamal-Hanjani, Selvaraju Veeriah, John Le Quesne, Charles Swanton, Yinyin Yuan
Output of the trained CNN is then deconvolved to generate points as cell detection.
no code implementations • 22 Apr 2018 • Shan E Ahmed Raza, Linda Cheung, Muhammad Shaban, Simon Graham, David Epstein, Stella Pelengaris, Michael Khan, Nasir M. Rajpoot
Object segmentation and structure localization are important steps in automated image analysis pipelines for microscopy images.
Ranked #13 on Multi-tissue Nucleus Segmentation on Kumar