no code implementations • 28 Jun 2024 • Jonathan Ganz, Christian Marzahl, Jonas Ammeling, Barbara Richter, Chloé Puget, Daniela Denk, Elena A. Demeter, Flaviu A. Tabaran, Gabriel Wasinger, Karoline Lipnik, Marco Tecilla, Matthew J. Valentine, Michael J. Dark, Niklas Abele, Pompei Bolfa, Ramona Erber, Robert Klopfleisch, Sophie Merz, Taryn A. Donovan, Samir Jabari, Christof A. Bertram, Katharina Breininger, Marc Aubreville
Counting MFs on slides stained against PHH3 leads to higher agreement among raters and has therefore recently been used as a ground truth for the annotation of MFs in H&E.
no code implementations • 15 Nov 2023 • Jonas Ammeling, Moritz Hecker, Jonathan Ganz, Taryn A. Donovan, Christof A. Bertram, Katharina Breininger, Marc Aubreville
The volume-corrected mitotic index (M/V-Index) was shown to provide prognostic value in invasive breast carcinomas.
no code implementations • 27 Sep 2023 • Marc Aubreville, Nikolas Stathonikos, Taryn A. Donovan, Robert Klopfleisch, Jonathan Ganz, Jonas Ammeling, Frauke Wilm, Mitko Veta, Samir Jabari, Markus Eckstein, Jonas Annuscheit, Christian Krumnow, Engin Bozaba, Sercan Cayir, Hongyan Gu, Xiang 'Anthony' Chen, Mostafa Jahanifar, Adam Shephard, Satoshi Kondo, Satoshi Kasai, Sujatha Kotte, VG Saipradeep, Maxime W. Lafarge, Viktor H. Koelzer, Ziyue Wang, Yongbing Zhang, Sen yang, Xiyue Wang, Katharina Breininger, Christof A. Bertram
The challenge provided annotated histologic tumor images from six different domains and evaluated the algorithmic approaches for mitotic figure detection provided by nine challenge participants on ten independent domains.
no code implementations • 26 Sep 2023 • Andreas Haghofer, Eda Parlak, Alexander Bartel, Taryn A. Donovan, Charles-Antoine Assenmacher, Pompei Bolfa, Michael J. Dark, Andrea Fuchs-Baumgartinger, Andrea Klang, Kathrin Jäger, Robert Klopfleisch, Sophie Merz, Barbara Richter, F. Yvonne Schulman, Hannah Janout, Jonathan Ganz, Josef Scharinger, Marc Aubreville, Stephan M. Winkler, Matti Kiupel, Christof A. Bertram
We assessed the following nuclear evaluation methods for measurement accuracy, reproducibility, and prognostic utility: 1) anisokaryosis (karyomegaly) estimates by 11 pathologists; 2) gold standard manual morphometry of at least 100 nuclei; 3) practicable manual morphometry with stratified sampling of 12 nuclei by 9 pathologists; and 4) automated morphometry using a deep learning-based segmentation algorithm.
no code implementations • 31 May 2023 • Christof A. Bertram, Taryn A. Donovan, Alexander Bartel
The goal of this systematic review is to scholarly analyze the methods and prognostic relevance of histologically measuring mitotic activity in canine tumors.
no code implementations • 2 May 2023 • Christof A. Bertram, Taryn A. Donovan, Alexander Bartel
The goal of this systematic review is scholarly analysis of all available references on mitotic activity in feline tumors, and to provide an overview of the measuring methods and prognostic value.
no code implementations • 15 Dec 2022 • Jonathan Ganz, Karoline Lipnik, Jonas Ammeling, Barbara Richter, Chloé Puget, Eda Parlak, Laura Diehl, Robert Klopfleisch, Taryn A. Donovan, Matti Kiupel, Christof A. Bertram, Katharina Breininger, Marc Aubreville
Nucleolar organizer regions (NORs) are parts of the DNA that are involved in RNA transcription.
1 code implementation • 12 Dec 2022 • Marc Aubreville, Jonathan Ganz, Jonas Ammeling, Taryn A. Donovan, Rutger H. J. Fick, Katharina Breininger, Christof A. Bertram
In this work, we perform, for the first time, automatic subtyping of mitotic figures into normal and atypical categories according to characteristic morphological appearances of the different phases of mitosis.
no code implementations • 6 Apr 2022 • Marc Aubreville, Nikolas Stathonikos, Christof A. Bertram, Robert Klopleisch, Natalie ter Hoeve, Francesco Ciompi, Frauke Wilm, Christian Marzahl, Taryn A. Donovan, Andreas Maier, Jack Breen, Nishant Ravikumar, Youjin Chung, Jinah Park, Ramin Nateghi, Fattaneh Pourakpour, Rutger H. J. Fick, Saima Ben Hadj, Mostafa Jahanifar, Nasir Rajpoot, Jakob Dexl, Thomas Wittenberg, Satoshi Kondo, Maxime W. Lafarge, Viktor H. Koelzer, Jingtang Liang, YuBo Wang, Xi Long, Jingxin Liu, Salar Razavi, April Khademi, Sen yang, Xiyue Wang, Mitko Veta, Katharina Breininger
The goal of the MICCAI MIDOG 2021 challenge has been to propose and evaluate methods that counter this domain shift and derive scanner-agnostic mitosis detection algorithms.
2 code implementations • 5 Jan 2021 • Christof A. Bertram, Taryn A. Donovan, Marco Tecilla, Florian Bartenschlager, Marco Fragoso, Frauke Wilm, Christian Marzahl, Katharina Breininger, Andreas Maier, Robert Klopfleisch, Marc Aubreville
For this study, we created the first open source data-set with 19, 983 annotations of BiNC and 1, 416 annotations of MuNC in 32 histological whole slide images of ccMCT.
no code implementations • 4 Dec 2020 • Frauke Wilm, Christof A. Bertram, Christian Marzahl, Alexander Bartel, Taryn A. Donovan, Charles-Antoine Assenmacher, Kathrin Becker, Mark Bennett, Sarah Corner, Brieuc Cossic, Daniela Denk, Martina Dettwiler, Beatriz Garcia Gonzalez, Corinne Gurtner, Annika Lehmbecker, Sophie Merz, Stephanie Plog, Anja Schmidt, Rebecca C. Smedley, Marco Tecilla, Tuddow Thaiwong, Katharina Breininger, Matti Kiupel, Andreas Maier, Robert Klopfleisch, Marc Aubreville
Density of mitotic figures in histologic sections is a prognostically relevant characteristic for many tumours.
1 code implementation • 24 Aug 2020 • Marc Aubreville, Christof A. Bertram, Taryn A. Donovan, Christian Marzahl, Andreas Maier, Robert Klopfleisch
We achieved a mean F1-score of 0. 791 on the test set and of up to 0. 696 on a human breast cancer dataset.