Optimizing chemoradiotherapy for malignant gliomas: a validated mathematical approach

no code implementations • 24 Apr 2025 • Miguel Perales-Patón, Matteo Italia, María Castelló-Pons, Irene Gómez-Soria, Juan Belmonte-Beitia, Pilar Sánchez-Gómez, Víctor M. Pérez-García

Through in silico trials, we identified optimized combination treatment protocols that may outperform the standard Stupp protocol.

Prognosis

Analysis of the MICCAI Brain Tumor Segmentation -- Metastases (BraTS-METS) 2025 Lighthouse Challenge: Brain Metastasis Segmentation on Pre- and Post-treatment MRI

no code implementations • 16 Apr 2025 • Nazanin Maleki, Raisa Amiruddin, Ahmed W. Moawad, Nikolay Yordanov, Athanasios Gkampenis, Pascal Fehringer, Fabian Umeh, Crystal Chukwurah, Fatima Memon, Bojan Petrovic, Justin Cramer, Mark Krycia, Elizabeth B. Shrickel, Ichiro Ikuta, Gerard Thompson, Lorenna Vidal, Vilma Kosovic, Adam E. Goldman-Yassen, Virginia Hill, Tiffany So, Sedra Mhana, Albara Alotaibi, Nathan Page, Prisha Bhatia, Marko Jakovljevic, Salma Abosabie, Sara Abosabie, Mohanad Ghonim, Mohamed Ghonim, Amirreza Manteghinejad, Anastasia Janas, Kiril Krantchev, Maruf Adewole, Jake Albrecht, Udunna Anazodo, Sanjay Aneja, Syed Muhammad Anwar, Timothy Bergquist, Veronica Chiang, Verena Chung, Gian Marco Conte, Farouk Dako, James Eddy, Ivan Ezhov, Nastaran Khalili, Keyvan Farahani, Juan Eugenio Iglesias, Zhifan Jiang, Elaine Johanson, Anahita Fathi Kazerooni, Florian Kofler, Dominic LaBella, Koen van Leemput, Hongwei Bran Li, Marius George Linguraru, Xinyang Liu, Zeke Meier, Bjoern H Menze, Harrison Moy, Klara Osenberg, Marie Piraud, Zachary Reitman, Russell Takeshi Shinohara, Chunhao Wang, Benedikt Wiestler, Walter Wiggins, Umber Shafique, Klara Willms, Arman Avesta, Khaled Bousabarah, Satrajit Chakrabarty, Nicolo Gennaro, Wolfgang Holler, Manpreet Kaur, Pamela Lamontagne, MingDe Lin, Jan Lost, Daniel S. Marcus, Ryan Maresca, Sarah Merkaj, Gabriel Cassinelli Pedersen, Marc von Reppert, Aristeidis Sotiras, Oleg Teytelboym, Niklas Tillmans, Malte Westerhoff, Ayda Youssef, Devon Godfrey, Scott Floyd, Andreas Rauschecker, Javier Villanueva-Meyer, Irada Pflüger, Jaeyoung Cho, Martin Bendszus, Gianluca Brugnara, Gloria J. Guzman Perez-Carillo, Derek R. Johnson, Anthony Kam, Benjamin Yin Ming Kwan, Lillian Lai, Neil U. Lall, Satya Narayana Patro, Lei Wu, Anu Bansal, Frederik Barkhof, Cristina Besada, Sammy Chu, Jason Druzgal, Alexandru Dusoi, Luciano Farage, Fabricio Feltrin, Amy Fong, Steve H. Fung, R. Ian Gray, Michael Iv, Alida A. Postma, Amit Mahajan, David Joyner, Chase Krumpelman, Laurent Letourneau-Guillon, Christie M. Lincoln, Mate E. Maros, Elka Miller, Fanny Morón, Esther A. Nimchinsky, Ozkan Ozsarlak, Uresh Patel, Saurabh Rohatgi, Atin Saha, Anousheh Sayah, Eric D. Schwartz, Robert Shih, Mark S. Shiroishi, Juan E. Small, Manoj Tanwar, Jewels Valerie, Brent D. Weinberg, Matthew L. White, Robert Young, Vahe M. Zohrabian, Aynur Azizova, Melanie Maria Theresa Brüßeler, Abdullah Okar, Luca Pasquini, Yasaman Sharifi, Gagandeep Singh, Nico Sollmann, Theodora Soumala, Mahsa Taherzadeh, Philipp Vollmuth, Martha Foltyn-Dumitru, Ajay Malhotra, Francesco Dellepiane, Víctor M. Pérez-García, Hesham Elhalawani, Maria Correia de Verdier, Sanaria Al Rubaiey, Rui Duarte Armindo, Kholod Ashraf, Moamen M. Asla, Mohamed Badawy, Jeroen Bisschop, Nima Broomand Lomer, Jan Bukatz, Jim Chen, Petra Cimflova, Felix Corr, Alexis Crawley, Lisa Deptula, Tasneem Elakhdar, Islam H. Shawali, Shahriar Faghani, Alexandra Frick, Vaibhav Gulati, Muhammad Ammar Haider, Fátima Hierro, Rasmus Holmboe Dahl, Sarah Maria Jacobs, Kuang-chun Jim Hsieh, Sedat G. Kandemirli, Katharina Kersting, Laura Kida, Sofia Kollia, Ioannis Koukoulithras, Xiao Li, Ahmed Abouelatta, Aya Mansour, Ruxandra-Catrinel Maria-Zamfirescu, Marcela Marsiglia, Yohana Sarahi Mateo-Camacho, Mark McArthur, Olivia McDonnel, Maire McHugh, Mana Moassefi, Samah Mostafa Morsi, Alexander Munteanu, Khanak K. Nandolia, Syed Raza Naqvi, Yalda Nikanpour, Mostafa Alnoury, Abdullah Mohamed Aly Nouh, Francesca Pappafava, Markand D. Patel, Samantha Petrucci, Eric Rawie, Scott Raymond, Borna Roohani, Sadeq Sabouhi, Laura M. Sanchez Garcia, Zoe Shaked, Pokhraj P. Suthar, Talissa Altes, Edvin Isufi, Yaseen Dhemesh, Jaime Gass, Jonathan Thacker, Abdul Rahman Tarabishy, Benjamin Turner, Sebastiano Vacca, George K. Vilanilam, Daniel Warren, David Weiss, Fikadu Worede, Sara Yousry, Wondwossen Lerebo, Alejandro Aristizabal, Alexandros Karargyris, Hasan Kassem, Sarthak Pati, Micah Sheller, Katherine E. Link, Evan Calabrese, Nourel Hoda Tahon, Ayman Nada, Jeffrey D. Rudie, Janet Reid, Kassa Darge, Aly H. Abayazeed, Philipp Lohmann, Yuri S. Velichko, Spyridon Bakas, Mariam Aboian

The BraTS-METS 2025 Lighthouse Challenge aims to address this critical need by establishing inter-rater and intra-rater variability in dataset annotation by generating high quality annotated datasets from four individual instances of segmentation by neuroradiologists while being recorded on video (two instances doing "from scratch" and two instances after AI pre-segmentation).

Brain Tumor Segmentation Prognosis +2

Geometric immunosuppression in CAR-T cell treatment: Insights from mathematical modeling

1 code implementation • 30 Jan 2025 • Silvia Bordel-Vozmediano, Soukaina Sabir, Lucía Benito-Barca, Bettina Weigelin, Víctor M. Pérez-García

Our main objective was to deepen our understanding of treatment effects by analyzing scenarios with different spatial distributions and varying the initial quantities of tumor and CAR-T cells.

A mathematical model for fibrous dysplasia: The role of the flow of mutant cells

no code implementations • 12 Feb 2024 • Mariia Soloviova, Juan Carlos Beltran Vargas, Luis Fernandez de Castro, Juan Belmonte-Beitia, Víctor M. Pérez-García, Magdalena Caballero

We present a simple mathematical model of the disease incorporating its basic known biology, to gain insight on the dynamics of the involved bone-cell populations, and shed light on its pathophysiology.

A glance at evolvability: a theoretical analysis of its role in the evolutionary dynamics of cell populations

no code implementations • 9 Feb 2024 • Juan Jiménez-Sánchez, Carmen Ortega-Sabater, Philip K. Maini, Víctor M. Pérez-García, Tommaso Lorenzi

Evolvability is defined as the ability of a population to generate heritable variation to facilitate its adaptation to new environments or selection pressures.

Universal scaling laws rule explosive growth inhuman cancers

no code implementations • 22 Apr 2021 • Víctor M. Pérez-García, Gabriel F. Calvo, Jesús J. Bosque, Odelaisy León-Triana, Juan Jiménez, Julián Pérez-Beteta, Juan Belmonte-Beitia, Manuel Valiente, Lucía Zhu, Pedro García-Gómez, Pilar Sánchez-Gómez, Esther Hernández-San Miguel, Rafael Hortigüela, Youness Azimzade, David Molina-García, Álvaro Martínez, Ángel Acosta Rojas, Ana Ortiz de Mendivil, Francois Vallette, Philippe Schucht, Michael Murek, María Pérez-Cano, David Albillo, Antonio F. Honguero Martínez, Germán A. Jiménez Londoño, Estanislao Arana, Ana M. García Vicente

Our models predicted that the emergence of superlinear allometric scaling laws is an inherently three-dimensional phenomenon.

Mathematical models of Leukaemia and its treatment: A review

no code implementations • 4 Nov 2020 • Salvador Chulián, Álvaro-Martínez Rubio, María Rosa, Víctor M. Pérez-García

Leukaemia accounts for around 3% of all cancer types diagnosed in adults, and is the most common type of cancer in children of paediatric age.

Dynamical properties of feedback signalling in B lymphopoiesis: A mathematical modelling approach

no code implementations • 8 Jul 2020 • Salvador Chulián, Alvaro Martínez-Rubio, Anna Marciniak-Czochra, Thomas Stiehl, Cristina Blázquez Goñi, Juan Francisco Rodríguez Gutiérrez, Manuel Ramirez Orellana, Ana Castillo Robleda, Víctor M. Pérez-García, María Rosa

The characteristics of self-regulation of this process make them suitable for a mathematical study.

CAR T cells for T-cell leukemias: Insights from mathematical models

no code implementations • 26 Apr 2020 • Víctor M. Pérez-García, O. León-Triana, M. Rosa, A. Pérez-Martínez

Immunotherapy has the potential to change the way all cancer types are treated and cured.