no code implementations • 26 Feb 2023 • Reza Mousapour, Kimia Yazdani, Wayne B. Hayes
In this paper, we propose two new measures, the Squared GO Score (SGS) and the Exposed G Score, to evaluate the quality of multiple network alignments while using functional information from Gene Ontology (GO) terms.
no code implementations • 10 Jul 2022 • Tingyin Ding, Utsav Jain, Wayne B. Hayes
While topology-driven local network alignment has a wide variety of potential applications outside bioinformatics, here we focus on the alignment of Protein-Protein Interaction (PPI) networks.
1 code implementation • 26 Apr 2022 • Siyue Wang, Giles R. S. Atkinson, Wayne B. Hayes
We argue that this failure of topology alone is due to the sparsity and incompleteness of the PPI network data of almost all species, which provides the network topology with a small signal-to-noise ratio that is effectively swamped when sequence information is added to the mix.
1 code implementation • 25 Apr 2022 • Siyue Wang, Xiaoyin Chen, Brent J. Frederisy, Benedict A. Mbakogu, Amy D. Kanne, Pasha Khosravi, Wayne B. Hayes
The function of a protein is defined by its interaction partners.
1 code implementation • 9 Oct 2020 • Wayne B. Hayes
Network alignment aims to uncover topologically similar regions in the protein-protein interaction (PPI) networks of two or more species under the assumption that topologically similar regions tend to perform similar functions.
2 code implementations • 22 Nov 2019 • Wayne B. Hayes
SANA is one of many algorithms proposed for the arena of biological network alignment.