Search Results for author: Xiangting Li

Found 9 papers, 3 papers with code

An efficient Wasserstein-distance approach for reconstructing jump-diffusion processes using parameterized neural networks

no code implementations3 Jun 2024 Mingtao Xia, Xiangting Li, Qijing Shen, Tom Chou

We analyze the Wasserstein distance ($W$-distance) between two probability distributions associated with two multidimensional jump-diffusion processes.

Gradient-flow adaptive importance sampling for Bayesian leave one out cross-validation with application to sigmoidal classification models

no code implementations13 Feb 2024 Joshua C Chang, Xiangting Li, Shixin Xu, Hao-Ren Yao, Julia Porcino, Carson Chow

We introduce gradient-flow-guided adaptive importance sampling (IS) transformations for stabilizing Monte-Carlo approximations of leave-one-out (LOO) cross-validated predictions for Bayesian models.

Reliable ligand discrimination in stochastic multistep kinetic proofreading: First passage time vs. product counting strategies

1 code implementation7 Feb 2024 Xiangting Li, Tom Chou

We find that loss of fidelity for longer proofreading steps relies on the specific strategy of information extraction and show that in the first-passage time (FPT) discrimination strategy, longer proofreading steps can exponentially improve the accuracy of KPR at the cost of speed.

Specificity

Squared Wasserstein-2 Distance for Efficient Reconstruction of Stochastic Differential Equations

no code implementations21 Jan 2024 Mingtao Xia, Xiangting Li, Qijing Shen, Tom Chou

We provide an analysis of the squared Wasserstein-2 ($W_2$) distance between two probability distributions associated with two stochastic differential equations (SDEs).

A Spectral Approach for Learning Spatiotemporal Neural Differential Equations

no code implementations28 Sep 2023 Mingtao Xia, Xiangting Li, Qijing Shen, Tom Chou

Rapidly developing machine learning methods has stimulated research interest in computationally reconstructing differential equations (DEs) from observational data which may provide additional insight into underlying causative mechanisms.

Stochastic nucleosome disassembly mediated by remodelers and histone fragmentation

1 code implementation6 Sep 2023 Xiangting Li, Tom Chou

The dissociation process can be facilitated by DNA binding proteins or processing molecular motors that compete with histones for histone-DNA contact sites.

The role of APOBEC3-induced mutations in the differential evolution of monkeypox virus

no code implementations7 Aug 2023 Xiangting Li, Sara Habibipour, Tom Chou, Otto O. Yang

Recent studies show that newly sampled monkeypox virus (MPXV) genomes exhibit mutations consistent with Apolipoprotein B mRNA Editing Catalytic Polypeptide-like3 (APOBEC3)-mediated editing, compared to MPXV genomes collected earlier.

Overcompensation of transient and permanent death rate increases in age-structured models with cannibalistic interactions

no code implementations1 Mar 2023 Mingtao Xia, Xiangting Li, Tom Chou

There has been renewed interest in understanding the mathematical structure of ecological population models that lead to overcompensation, the process by which a population recovers to a higher level after suffering a permanent increase in predation or harvesting.

Stochastic dynamics and ribosome-RNAP interactions in Transcription-Translation Coupling

1 code implementation10 Jul 2022 Xiangting Li, Tom Chou

Such transcription-translation coupling (TTC) has been evoked as a mechanism that speeds up the overall process, provides protection during the transcription, and/or regulates the timing of transcript and protein formation.

Translation

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