1 code implementation • 11 Feb 2025 • Ruining Deng, Tianyuan Yao, Yucheng Tang, Junlin Guo, Siqi Lu, Juming Xiong, Lining Yu, Quan Huu Cap, Pengzhou Cai, Libin Lan, Ze Zhao, Adrian Galdran, Amit Kumar, Gunjan Deotale, Dev Kumar Das, Inyoung Paik, Joonho Lee, Geongyu Lee, Yujia Chen, Wangkai Li, Zhaoyang Li, Xuege Hou, Zeyuan Wu, Shengjin Wang, Maximilian Fischer, Lars Kramer, Anghong Du, Le Zhang, Maria Sanchez Sanchez, Helena Sanchez Ulloa, David Ribalta Heredia, Carlos Perez de Arenaza Garcia, Shuoyu Xu, Bingdou He, Xinping Cheng, Tao Wang, Noemie Moreau, Katarzyna Bozek, Shubham Innani, Ujjwal Baid, Kaura Solomon Kefas, Bennett A. Landman, Yu Wang, Shilin Zhao, Mengmeng Yin, Haichun Yang, Yuankai Huo
Chronic kidney disease (CKD) is a major global health issue, affecting over 10% of the population and causing significant mortality.
1 code implementation • 11 Feb 2025 • Ruining Deng, Yihe Yang, David J. Pisapia, Benjamin Liechty, Junchao Zhu, Juming Xiong, Junlin Guo, Zhengyi Lu, Jiacheng Wang, Xing Yao, Runxuan Yu, Rendong Zhang, Gaurav Rudravaram, Mengmeng Yin, Pinaki Sarder, Haichun Yang, Yuankai Huo, Mert R. Sabuncu
The Consensus Matrix defines regions where both the AI and annotators agree on cell and non-cell annotations, which are prioritized with stronger supervision.
no code implementations • 6 Feb 2025 • Juming Xiong, Hou Xiong, Quan Liu, Ruining Deng, Regina N Tyree, Girish Hiremath, Yuankai Huo
Eosinophilic esophagitis (EoE) is a chronic esophageal disorder marked by eosinophil-dominated inflammation.
no code implementations • 6 Feb 2025 • Juming Xiong, Muyang Li, Ruining Deng, Tianyuan Yao, Regina N Tyree, Girish Hiremath, Yuankai Huo
Image stitching techniques address this issue by providing a continuous and complete visualization of the examined area.
no code implementations • 3 Feb 2025 • Maliha Hossain, Yuankai Huo, Xinqiang Yan, Xiao Wang
Instead of directly using a 3D prior, this work proposes a BM3D Multi Slice Fusion (BM3D-MSF) prior that uses multiple 2D image denoisers fused to act as a fully 3D prior model in Plug and Play reconstruction approach.
no code implementations • 28 Jan 2025 • Chongyu Qu, Ritchie Zhao, Ye Yu, Bin Liu, Tianyuan Yao, Junchao Zhu, Bennett A. Landman, Yucheng Tang, Yuankai Huo
Second, we convert this fake quantization into real quantization via TensorRT engine on real GPUs, resulting in real-world reductions in model size and inference latency.
no code implementations • 23 Jan 2025 • Tianyuan Yao, Zhiyuan Li, Praitayini Kanakaraj, Derek B. Archer, Kurt Schilling, Lori Beason-Held, Susan Resnick, Bennett A. Landman, Yuankai Huo
Diffusion-weighted Magnetic Resonance Imaging (dMRI) is an essential tool in neuroimaging.
no code implementations • 21 Jan 2025 • Zhengyi Lu, Hao Liang, Ming Lu, Xiao Wang, Xinqiang Yan, Yuankai Huo
This approach offers a faster and more efficient solution to RF shimming challenges in UHF MRI.
no code implementations • 10 Jan 2025 • Yuechen Yang, Yu Wang, Tianyuan Yao, Ruining Deng, Mengmeng Yin, Shilin Zhao, Haichun Yang, Yuankai Huo
These results highlight PySpatial's potential to handle large-scale WSI analysis with enhanced efficiency and accuracy, paving the way for broader applications in digital pathology.
1 code implementation • 10 Jan 2025 • Yanfan Zhu, Issac Lyngaas, Murali Gopalakrishnan Meena, Mary Ellen I. Koran, Bradley Malin, Daniel Moyer, Shunxing Bao, Anuj Kapadia, Xiao Wang, Bennett Landman, Yuankai Huo
A prominent method within this area, called Unlearnable Clustering (UC), has shown improved UE performance with larger batch sizes but was previously limited by computational resources.
1 code implementation • 20 Dec 2024 • Jun Ma, Feifei Li, Sumin Kim, Reza Asakereh, Bao-Hiep Le, Dang-Khoa Nguyen-Vu, Alexander Pfefferle, Muxin Wei, Ruochen Gao, Donghang Lyu, Songxiao Yang, Lennart Purucker, Zdravko Marinov, Marius Staring, Haisheng Lu, Thuy Thanh Dao, Xincheng Ye, Zhi Li, Gianluca Brugnara, Philipp Vollmuth, Martha Foltyn-Dumitru, Jaeyoung Cho, Mustafa Ahmed Mahmutoglu, Martin Bendszus, Irada Pflüger, Aditya Rastogi, Dong Ni, Xin Yang, Guang-Quan Zhou, Kaini Wang, Nicholas Heller, Nikolaos Papanikolopoulos, Christopher Weight, Yubing Tong, Jayaram K Udupa, Cahill J. Patrick, Yaqi Wang, Yifan Zhang, Francisco Contijoch, Elliot McVeigh, Xin Ye, Shucheng He, Robert Haase, Thomas Pinetz, Alexander Radbruch, Inga Krause, Erich Kobler, Jian He, Yucheng Tang, Haichun Yang, Yuankai Huo, Gongning Luo, Kaisar Kushibar, Jandos Amankulov, Dias Toleshbayev, Amangeldi Mukhamejan, Jan Egger, Antonio Pepe, Christina Gsaxner, Gijs Luijten, Shohei Fujita, Tomohiro Kikuchi, Benedikt Wiestler, Jan S. Kirschke, Ezequiel de la Rosa, Federico Bolelli, Luca Lumetti, Costantino Grana, Kunpeng Xie, Guomin Wu, Behrus Puladi, Carlos Martín-Isla, Karim Lekadir, Victor M. Campello, Wei Shao, Wayne Brisbane, Hongxu Jiang, Hao Wei, Wu Yuan, Shuangle Li, Yuyin Zhou, Bo wang
Promptable segmentation foundation models have emerged as a transformative approach to addressing the diverse needs in medical images, but most existing models require expensive computing, posing a big barrier to their adoption in clinical practice.
1 code implementation • 4 Dec 2024 • Junchao Zhu, Ruining Deng, Tianyuan Yao, Juming Xiong, Chongyu Qu, Junlin Guo, Siqi Lu, Mengmeng Yin, Yu Wang, Shilin Zhao, Haichun Yang, Yuankai Huo
Expanding ST to three-dimensional (3D) volumes is challenging due to the prohibitive costs; a 2D ST acquisition already costs over 50 times more than whole slide imaging (WSI), and a full 3D volume with 10 sections can be an order of magnitude more expensive.
no code implementations • 27 Nov 2024 • Jialin Yue, Tianyuan Yao, Ruining Deng, Siqi Lu, Junlin Guo, Quan Liu, Mengmeng Yin, Juming Xiong, Haichun Yang, Yuankai Huo
Artificial intelligence (AI) has demonstrated significant success in automating the detection of glomeruli, the key functional units of the kidney, from whole slide images (WSIs) in kidney pathology.
1 code implementation • 25 Nov 2024 • Lining Yu, Mengmeng Yin, Ruining Deng, Quan Liu, Tianyuan Yao, Can Cui, Junlin Guo, Yu Wang, Yaohong Wang, Shilin Zhao, Haichun Yang, Yuankai Huo
In this study, we leverage the Glo-In-One toolkit to version 2 with fine-grained segmentation capabilities, curating 14 distinct labels for tissue regions, cells, and lesions across a dataset of 23, 529 annotated glomeruli across human and mouse histopathology data.
no code implementations • 24 Nov 2024 • Yifei Wu, Juming Xiong, Tianyuan Yao, Ruining Deng, Junlin Guo, Jialin Yue, Naweed Chowdhury, Yuankai Huo
Interestingly, eosinophils are predominantly located in the gastrointestinal (GI) tract, which has prompted the release of numerous deep learning models trained on GI data.
1 code implementation • 31 Oct 2024 • Junlin Guo, Siqi Lu, Can Cui, Ruining Deng, Tianyuan Yao, Zhewen Tao, Yizhe Lin, Marilyn Lionts, Quan Liu, Juming Xiong, Yu Wang, Shilin Zhao, Catie Chang, Mitchell Wilkes, Mengmeng Yin, Haichun Yang, Yuankai Huo
This study establishes a benchmark for the development and deployment of cell vision foundation models tailored for real-world data applications.
1 code implementation • 29 Oct 2024 • Chenyu Gao, Michael E. Kim, Karthik Ramadass, Praitayini Kanakaraj, Aravind R. Krishnan, Adam M. Saunders, Nancy R. Newlin, Ho Hin Lee, Qi Yang, Warren D. Taylor, Brian D. Boyd, Lori L. Beason-Held, Susan M. Resnick, Lisa L. Barnes, David A. Bennett, Katherine D. Van Schaik, Derek B. Archer, Timothy J. Hohman, Angela L. Jefferson, Ivana Išgum, Daniel Moyer, Yuankai Huo, Kurt G. Schilling, Lianrui Zuo, Shunxing Bao, Nazirah Mohd Khairi, Zhiyuan Li, Christos Davatzikos, Bennett A. Landman
We observe difference between our dMRI-based brain age and T1w MRI-based brain age across stages of neurodegeneration, with dMRI-based brain age being older than T1w MRI-based brain age in participants transitioning from cognitively normal (CN) to mild cognitive impairment (MCI), but younger in participants already diagnosed with Alzheimer's disease (AD).
no code implementations • 2 Oct 2024 • Muyang Li, Juming Xiong, Ruining Deng, Tianyuan Yao, Regina N Tyree, Girish Hiremath, Yuankai Huo
Endoscopy is a crucial tool for diagnosing the gastrointestinal tract, but its effectiveness is often limited by a narrow field of view and the dynamic nature of the internal environment, especially in the esophagus, where complex and repetitive patterns make image stitching challenging.
no code implementations • 20 Sep 2024 • Zhiyuan Li, Tianyuan Yao, Praitayini Kanakaraj, Chenyu Gao, Shunxing Bao, Lianrui Zuo, Michael E. Kim, Nancy R. Newlin, Gaurav Rudravaram, Nazirah M. Khairi, Yuankai Huo, Kurt G. Schilling, Walter A. Kukull, Arthur W. Toga, Derek B. Archer, Timothy J. Hohman, Bennett A. Landman
We hypothesize that by this design the proposed framework can enhance the imputation performance of the dMRI scans and therefore be useful for repairing whole-brain tractography in corrupted dMRI scans with incomplete FOV.
1 code implementation • 6 Sep 2024 • Lucas W. Remedios, Han Liu, Samuel W. Remedios, Lianrui Zuo, Adam M. Saunders, Shunxing Bao, Yuankai Huo, Alvin C. Powers, John Virostko, Bennett A. Landman
We trained a collection of basic UNets with different fusion points, spanning from early to late, to assess how early through late fusion influenced segmentation performance on imperfectly aligned images.
no code implementations • 26 Aug 2024 • Shiyu Wang, Ziyuan Xu, Laurent M. Lochard, Yamin Li, Jiawen Fan, Jingyuan E. Chen, Yuankai Huo, Mara Mather, Roza G. Bayrak, Catie Chang
Interactions between the brain and body are of fundamental importance for human behavior and health.
no code implementations • 21 Aug 2024 • Zhengyi Lu, Hao Liang, Xiao Wang, Xinqiang Yan, Yuankai Huo
We propose a two-step deep learning strategy.
1 code implementation • 17 Aug 2024 • Junchao Zhu, Mengmeng Yin, Ruining Deng, Yitian Long, Yu Wang, Yaohong Wang, Shilin Zhao, Haichun Yang, Yuankai Huo
Cross-species homologous data, such as mouse kidney data, which exhibits high structural and feature similarity to human kidneys, has the potential to enhance model performance on human datasets.
1 code implementation • 15 Aug 2024 • Yanfan Zhu, Yash Singh, Khaled Younis, Shunxing Bao, Yuankai Huo
Topological data analysis (TDA) uncovers crucial properties of objects in medical imaging.
4 code implementations • 9 Aug 2024 • Junlin Guo, Siqi Lu, Can Cui, Ruining Deng, Tianyuan Yao, Zhewen Tao, Yizhe Lin, Marilyn Lionts, Quan Liu, Juming Xiong, Yu Wang, Shilin Zhao, Catie Chang, Mitchell Wilkes, Mengmeng Yin, Haichun Yang, Yuankai Huo
Among the evaluated models, CellViT demonstrated superior performance in segmenting nuclei in kidney pathology.
no code implementations • 6 Aug 2024 • Siqi Lu, Junlin Guo, James R Zimmer-Dauphinee, Jordan M Nieusma, Xiao Wang, Parker VanValkenburgh, Steven A Wernke, Yuankai Huo
Artificial Intelligence (AI) technologies have profoundly transformed the field of remote sensing, revolutionizing data collection, processing, and analysis.
no code implementations • 25 Jul 2024 • Lining Yu, Mengmeng Yin, Ruining Deng, Quan Liu, Tianyuan Yao, Can Cui, Yitian Long, Yu Wang, Yaohong Wang, Shilin Zhao, Haichun Yang, Yuankai Huo
To answer this question, we introduced GLAM, a deep learning study for fine-grained segmentation of human kidney lesions using a mouse model, addressing mouse-to-human transfer learning, by evaluating different learning strategies for segmenting human pathological lesions using zero-shot transfer learning and hybrid learning by leveraging mouse samples.
no code implementations • 19 Jul 2024 • Muyang Li, Can Cui, Quan Liu, Ruining Deng, Tianyuan Yao, Marilyn Lionts, Yuankai Huo
Our extensive experiments across multiple medical datasets reveal that data distillation can significantly reduce dataset size while maintaining comparable model performance to that achieved with the full dataset, suggesting that a small, representative sample of images can serve as a reliable indicator of distillation success.
no code implementations • 13 Jul 2024 • Can Cui, Ruining Deng, Junlin Guo, Quan Liu, Tianyuan Yao, Haichun Yang, Yuankai Huo
The Vision Foundation Model has recently gained attention in medical image analysis.
no code implementations • 3 Jul 2024 • Yucheng Tang, Yufan He, Vishwesh Nath, Pengfeig Guo, Ruining Deng, Tianyuan Yao, Quan Liu, Can Cui, Mengmeng Yin, Ziyue Xu, Holger Roth, Daguang Xu, Haichun Yang, Yuankai Huo
In this paper, we propose the holistic histopathology (HoloHisto) segmentation method to achieve end-to-end segmentation on gigapixel WSIs, whose maximum resolution is above 80, 000$\times$70, 000 pixels.
1 code implementation • 30 Jun 2024 • Ruining Deng, Quan Liu, Can Cui, Tianyuan Yao, Juming Xiong, Shunxing Bao, Hao Li, Mengmeng Yin, Yu Wang, Shilin Zhao, Yucheng Tang, Haichun Yang, Yuankai Huo
Panoramic image segmentation in computational pathology presents a remarkable challenge due to the morphologically complex and variably scaled anatomy.
1 code implementation • 27 Jun 2024 • Jialin Yue, Tianyuan Yao, Ruining Deng, Quan Liu, Juming Xiong, Junlin Guo, Haichun Yang, Yuankai Huo
Additionally, we assess the efficiency of two annotation methods, fully manual annotation and a human-in-the-loop (HITL) approach, in labeling 200, 000 glomeruli.
no code implementations • 18 Jun 2024 • Xin Yu, Qi Yang, Han Liu, Ho Hin Lee, Yucheng Tang, Lucas W. Remedios, Michael E. Kim, Rendong Zhang, Shunxing Bao, Yuankai Huo, Ann Zenobia Moore, Luigi Ferrucci, Bennett A. Landman
2D single-slice abdominal computed tomography (CT) enables the assessment of body habitus and organ health with low radiation exposure.
no code implementations • 28 May 2024 • Quan Liu, Ruining Deng, Can Cui, Tianyuan Yao, Vishwesh Nath, Yucheng Tang, Yuankai Huo
Multi-modal learning adeptly integrates visual and textual data, but its application to histopathology image and text analysis remains challenging, particularly with large, high-resolution images like gigapixel Whole Slide Images (WSIs).
no code implementations • 27 May 2024 • Quan Liu, Brandon T. Swartz, Ivan Kravchenko, Jason G. Valentine, Yuankai Huo
In this paper, we propose a large kernel lightweight segmentation model, ExtremeMETA.
no code implementations • 6 May 2024 • Chenyu Gao, Shunxing Bao, Michael Kim, Nancy Newlin, Praitayini Kanakaraj, Tianyuan Yao, Gaurav Rudravaram, Yuankai Huo, Daniel Moyer, Kurt Schilling, Walter Kukull, Arthur Toga, Derek Archer, Timothy Hohman, Bennett Landman, Zhiyuan Li
We hypothesize that the imputed image with complete FOV can improve the whole-brain tractography for corrupted data with incomplete FOV.
no code implementations • 15 Apr 2024 • Enzhi Zhang, Isaac Lyngaas, Peng Chen, Xiao Wang, Jun Igarashi, Yuankai Huo, Mohamed Wahib, Masaharu Munetomo
For high-resolution images, e. g. microscopic pathology images, the quadratic compute and memory cost prohibits the use of an attention-based model, if we are to use smaller patch sizes that are favorable in segmentation.
no code implementations • 18 Mar 2024 • Juming Xiong, Ethan H. Nguyen, Yilin Liu, Ruining Deng, Regina N Tyree, Hernan Correa, Girish Hiremath, Yaohong Wang, Haichun Yang, Agnes B. Fogo, Yuankai Huo
Recently, circle representation has been introduced for medical imaging, designed specifically to enhance the detection of instance objects that are spherically shaped (e. g., cells, glomeruli, and nuclei).
no code implementations • CVPR 2024 • Ruining Deng, Quan Liu, Can Cui, Tianyuan Yao, Jialin Yue, Juming Xiong, Lining Yu, Yifei Wu, Mengmeng Yin, Yu Wang, Shilin Zhao, Yucheng Tang, Haichun Yang, Yuankai Huo
Understanding the anatomy of renal pathology is crucial for advancing disease diagnostics, treatment evaluation, and clinical research.
no code implementations • 15 Jan 2024 • Ho Hin Lee, Yu Gu, Theodore Zhao, Yanbo Xu, Jianwei Yang, Naoto Usuyama, Cliff Wong, Mu Wei, Bennett A. Landman, Yuankai Huo, Alberto Santamaria-Pang, Hoifung Poon
This transformative technology, originally developed for general-purpose computer vision, has found rapid application in medical image processing.
no code implementations • 15 Jan 2024 • Quan Liu, Jiawen Yao, Lisha Yao, Xin Chen, Jingren Zhou, Le Lu, Ling Zhang, Zaiyi Liu, Yuankai Huo
The contribution of the paper is three-fold: (1) $M^{2}$Fusion is the first pipeline of multi-level fusion on pathology WSI and 3D radiology CT image for MSI prediction; (2) CT images are the first time integrated into multimodal fusion for CRC MSI prediction; (3) feature-level fusion strategy is evaluated on both Transformer-based and CNN-based method.
no code implementations • 11 Jan 2024 • Lucas W. Remedios, Shunxing Bao, Samuel W. Remedios, Ho Hin Lee, Leon Y. Cai, Thomas Li, Ruining Deng, Can Cui, Jia Li, Qi Liu, Ken S. Lau, Joseph T. Roland, Mary K. Washington, Lori A. Coburn, Keith T. Wilson, Yuankai Huo, Bennett A. Landman
In this paper, we propose to use inter-modality learning to label previously un-labelable cell types on virtual H&E.
no code implementations • 9 Jan 2024 • Hanliang Xu, Nancy R. Newlin, Michael E. Kim, Chenyu Gao, Praitayini Kanakaraj, Aravind R. Krishnan, Lucas W. Remedios, Nazirah Mohd Khairi, Kimberly Pechman, Derek Archer, Timothy J. Hohman, Angela L. Jefferson, The BIOCARD Study Team, Ivana Isgum, Yuankai Huo, Daniel Moyer, Kurt G. Schilling, Bennett A. Landman
First, we plotted the graph measures and used coefficient of variation (CoV) and the Mann-Whitney U test to evaluate different methods' effectiveness in removing site effects on the matrices and the derived graph measures.
no code implementations • 5 Jan 2024 • Ho Hin Lee, Adam M. Saunders, Michael E. Kim, Samuel W. Remedios, Lucas W. Remedios, Yucheng Tang, Qi Yang, Xin Yu, Shunxing Bao, Chloe Cho, Louise A. Mawn, Tonia S. Rex, Kevin L. Schey, Blake E. Dewey, Jeffrey M. Spraggins, Jerry L. Prince, Yuankai Huo, Bennett A. Landman
These variations limit the feasibility and robustness of generalizing population-wise features of eye organs to an unbiased spatial reference.
no code implementations • 6 Nov 2023 • Chenyu Gao, Michael E. Kim, Ho Hin Lee, Qi Yang, Nazirah Mohd Khairi, Praitayini Kanakaraj, Nancy R. Newlin, Derek B. Archer, Angela L. Jefferson, Warren D. Taylor, Brian D. Boyd, Lori L. Beason-Held, Susan M. Resnick, The BIOCARD Study Team, Yuankai Huo, Katherine D. Van Schaik, Kurt G. Schilling, Daniel Moyer, Ivana Išgum, Bennett A. Landman
We find that the ResNet model captures subtler, non-macrostructural features for brain age prediction.
1 code implementation • 30 Sep 2023 • Ho Hin Lee, Quan Liu, Qi Yang, Xin Yu, Shunxing Bao, Yuankai Huo, Bennett A. Landman
We hypothesize that deformable convolution can be an exploratory alternative to combine all advantages from the previous operators, providing long-range dependency, adaptive spatial aggregation and computational efficiency as a foundation backbone.
1 code implementation • 17 Sep 2023 • Xin Yu, Qi Yang, Yucheng Tang, Riqiang Gao, Shunxing Bao, Leon Y. Cai, Ho Hin Lee, Yuankai Huo, Ann Zenobia Moore, Luigi Ferrucci, Bennett A. Landman
We further evaluate our method's capability to harmonize longitudinal positional variation on 1033 subjects from the Baltimore Longitudinal Study of Aging (BLSA) dataset, which contains longitudinal single abdominal slices, and confirmed that our method can harmonize the slice positional variance in terms of visceral fat area.
1 code implementation • 8 Sep 2023 • Xin Yu, Yucheng Tang, Qi Yang, Ho Hin Lee, Shunxing Bao, Yuankai Huo, Bennett A. Landman
Subsequently, the model is finetuned with 45 T1w 3D volumes from Open Access Series Imaging Studies (OASIS) where both 133 whole brain classes and TICV/PFV labels are available.
no code implementations • 5 Sep 2023 • Muhao Liu, Chenyang Qi, Shunxing Bao, Quan Liu, Ruining Deng, Yu Wang, Shilin Zhao, Haichun Yang, Yuankai Huo
However, very few, if any, deep learning based approaches have been applied to kidney layer structure segmentation.
no code implementations • 20 Aug 2023 • Shunxing Bao, Sichen Zhu, Vasantha L Kolachala, Lucas W. Remedios, Yeonjoo Hwang, Yutong Sun, Ruining Deng, Can Cui, Yike Li, Jia Li, Joseph T. Roland, Qi Liu, Ken S. Lau, Subra Kugathasan, Peng Qiu, Keith T. Wilson, Lori A. Coburn, Bennett A. Landman, Yuankai Huo
This analysis is based on data collected at the two research institutes.
1 code implementation • 17 Aug 2023 • Yilin Liu, Ruining Deng, Juming Xiong, Regina N Tyree, Hernan Correa, Girish Hiremath, Yaohong Wang, Yuankai Huo
In this paper, we propose the multi-label CircleSnake model for instance segmentation on Eos.
1 code implementation • 11 Aug 2023 • Juming Xiong, Yilin Liu, Ruining Deng, Regina N Tyree, Hernan Correa, Girish Hiremath, Yaohong Wang, Yuankai Huo
Eosinophilic Esophagitis (EoE) is a chronic, immune/antigen-mediated esophageal disease, characterized by symptoms related to esophageal dysfunction and histological evidence of eosinophil-dominant inflammation.
1 code implementation • 10 Aug 2023 • Jiayuan Chen, Yu Wang, Ruining Deng, Quan Liu, Can Cui, Tianyuan Yao, Yilin Liu, Jianyong Zhong, Agnes B. Fogo, Haichun Yang, Shilin Zhao, Yuankai Huo
Podocytes, specialized epithelial cells that envelop the glomerular capillaries, play a pivotal role in maintaining renal health.
no code implementations • 10 Aug 2023 • Xueyuan Li, Ruining Deng, Yucheng Tang, Shunxing Bao, Haichun Yang, Yuankai Huo
In this paper, we explore the potential of bypassing pixel-level delineation by employing the recent segment anything model (SAM) on weak box annotation in a zero-shot learning approach.
no code implementations • 10 Aug 2023 • Franklin Hu, Ruining Deng, Shunxing Bao, Haichun Yang, Yuankai Huo
While deep learning-based methods offer a solution for automatic segmentation, most suffer from a limitation: they are designed for and restricted to training on single-site, single-scale data.
1 code implementation • 10 Aug 2023 • Haoju Leng, Ruining Deng, Shunxing Bao, Dazheng Fang, Bryan A. Millis, Yucheng Tang, Haichun Yang, Xiao Wang, Yifan Peng, Lipeng Wan, Yuankai Huo
The performance evaluation encompasses two key scenarios: (1) a pure CPU-based image analysis scenario ("CPU scenario"), and (2) a GPU-based deep learning framework scenario ("GPU scenario").
no code implementations • 21 Jul 2023 • Quan Liu, Hanyu Zheng, Brandon T. Swartz, Ho Hin Lee, Zuhayr Asad, Ivan Kravchenko, Jason G. Valentine, Yuankai Huo
However, the digital design of the metamaterial neural network (MNN) is fundamentally limited by its physical limitations, such as precision, noise, and bandwidth during fabrication.
no code implementations • 3 Jul 2023 • Can Cui, Yaohong Wang, Shunxing Bao, Yucheng Tang, Ruining Deng, Lucas W. Remedios, Zuhayr Asad, Joseph T. Roland, Ken S. Lau, Qi Liu, Lori A. Coburn, Keith T. Wilson, Bennett A. Landman, Yuankai Huo
Many anomaly detection approaches, especially deep learning methods, have been recently developed to identify abnormal image morphology by only employing normal images during training.
no code implementations • 1 Jul 2023 • Can Cui, Ruining Deng, Quan Liu, Tianyuan Yao, Shunxing Bao, Lucas W. Remedios, Yucheng Tang, Yuankai Huo
The Segment Anything Model (SAM) is a recently proposed prompt-based segmentation model in a generic zero-shot segmentation approach.
no code implementations • 12 Jun 2023 • Hanyu Zheng, Quan Liu, Ivan I. Kravchenko, Xiaomeng Zhang, Yuankai Huo, Jason G. Valentine
Rapid developments in machine vision have led to advances in a variety of industries, from medical image analysis to autonomous systems.
no code implementations • 5 Jun 2023 • Tianyuan Yao, Francois Rheault, Leon Y Cai, Vishwesh Nath, Zuhayr Asad, Nancy Newlin, Can Cui, Ruining Deng, Karthik Ramadass, Andrea Shafer, Susan Resnick, Kurt Schilling, Bennett A. Landman, Yuankai Huo
From the experimental results, the proposed data-driven framework outperforms the existing benchmarks in repeated fODF estimation.
no code implementations • 2 Jun 2023 • Yinchi Zhou, Ho Hin Lee, Yucheng Tang, Xin Yu, Qi Yang, Shunxing Bao, Jeffrey M. Spraggins, Yuankai Huo, Bennett A. Landman
Briefly, DEEDs affine and non-rigid registration are performed to transfer patient abdominal volumes to a fixed high-resolution atlas template.
1 code implementation • 31 May 2023 • Ruining Deng, Yanwei Li, Peize Li, Jiacheng Wang, Lucas W. Remedios, Saydolimkhon Agzamkhodjaev, Zuhayr Asad, Quan Liu, Can Cui, Yaohong Wang, Yihan Wang, Yucheng Tang, Haichun Yang, Yuankai Huo
The contribution of this paper is threefold: (1) We proposed a molecular-empowered learning scheme for multi-class cell segmentation using partial labels from lay annotators; (2) The proposed method integrated Giga-pixel level molecular-morphology cross-modality registration, molecular-informed annotation, and molecular-oriented segmentation model, so as to achieve significantly superior performance via 3 lay annotators as compared with 2 experienced pathologists; (3) A deep corrective learning (learning with imperfect label) method is proposed to further improve the segmentation performance using partially annotated noisy data.
1 code implementation • 23 May 2023 • Haoju Leng, Ruining Deng, Zuhayr Asad, R. Michael Womick, Haichun Yang, Lipeng Wan, Yuankai Huo
Our proposed method's innovative contribution is two-fold: (1) a Docker is released for an end-to-end slide-wise multi-tissue segmentation for WSIs; and (2) the pipeline is deployed on a GPU to accelerate the prediction, achieving better segmentation quality in less time.
1 code implementation • 19 May 2023 • Peize Li, Ruining Deng, Yuankai Huo
In this paper, we provide a Docker for an end-to-end 3D slide-wise registration pipeline on needle biopsy serial sections in a multi-stain paradigm.
no code implementations • 24 Apr 2023 • Lucas W. Remedios, Leon Y. Cai, Samuel W. Remedios, Karthik Ramadass, Aravind Krishnan, Ruining Deng, Can Cui, Shunxing Bao, Lori A. Coburn, Yuankai Huo, Bennett A. Landman
The M1 Ultra SoC was able to train the model directly on gigapixel images (16000$\times$64000 pixels, 1. 024 billion pixels) with a batch size of 1 using over 100 GB of unified memory for the process at an average speed of 1 minute and 21 seconds per batch with Tensorflow 2/Keras.
no code implementations • 9 Apr 2023 • Ruining Deng, Can Cui, Quan Liu, Tianyuan Yao, Lucas W. Remedios, Shunxing Bao, Bennett A. Landman, Lee E. Wheless, Lori A. Coburn, Keith T. Wilson, Yaohong Wang, Shilin Zhao, Agnes B. Fogo, Haichun Yang, Yucheng Tang, Yuankai Huo
However, it does not consistently achieve satisfying performance for dense instance object segmentation, even with 20 prompts (clicks/boxes) on each image.
no code implementations • 7 Apr 2023 • Kaiwen Xu, Aravind R. Krishnan, Thomas Z. Li, Yuankai Huo, Kim L. Sandler, Fabien Maldonado, Bennett A. Landman
Anatomically consistent field-of-view (FOV) completion to recover truncated body sections has important applications in quantitative analyses of computed tomography (CT) with limited FOV.
1 code implementation • 1 Apr 2023 • Ruining Deng, Can Cui, Lucas W. Remedios, Shunxing Bao, R. Michael Womick, Sophie Chiron, Jia Li, Joseph T. Roland, Ken S. Lau, Qi Liu, Keith T. Wilson, Yaohong Wang, Lori A. Coburn, Bennett A. Landman, Yuankai Huo
Analyzing high resolution whole slide images (WSIs) with regard to information across multiple scales poses a significant challenge in digital pathology.
no code implementations • 29 Mar 2023 • Tianyuan Yao, Nancy Newlin, Praitayini Kanakaraj, Vishwesh Nath, Leon Y Cai, Karthik Ramadass, Kurt Schilling, Bennett A. Landman, Yuankai Huo
Diffusion-weighted (DW) MRI measures the direction and scale of the local diffusion process in every voxel through its spectrum in q-space, typically acquired in one or more shells.
2 code implementations • 10 Mar 2023 • Ho Hin Lee, Quan Liu, Shunxing Bao, Qi Yang, Xin Yu, Leon Y. Cai, Thomas Li, Yuankai Huo, Xenofon Koutsoukos, Bennett A. Landman
We hypothesize that convolution with LK sizes is limited to maintain an optimal convergence for locality learning.
1 code implementation • 30 Nov 2022 • Qi Yang, Xin Yu, Ho Hin Lee, Leon Y. Cai, Kaiwen Xu, Shunxing Bao, Yuankai Huo, Ann Zenobia Moore, Sokratis Makrogiannis, Luigi Ferrucci, Bennett A. Landman
The proposed pipeline is effective and robust in extracting muscle groups on 2D single slice CT thigh images. The container is available for public use at https://github. com/MASILab/DA_CT_muscle_seg
no code implementations • 2 Nov 2022 • Ethan H. Nguyen, Haichun Yang, Zuhayr Asad, Ruining Deng, Agnes B. Fogo, Yuankai Huo
Circle representation has recently been introduced as a medical imaging optimized representation for more effective instance object detection on ball-shaped medical objects.
1 code implementation • 16 Oct 2022 • Ho Hin Lee, Yucheng Tang, Han Liu, Yubo Fan, Leon Y. Cai, Qi Yang, Xin Yu, Shunxing Bao, Yuankai Huo, Bennett A. Landman
We evaluate our proposed approach on multi-organ segmentation with both non-contrast CT (NCCT) datasets and the MICCAI 2015 BTCV Challenge contrast-enhance CT (CECT) datasets.
2 code implementations • 29 Sep 2022 • Ho Hin Lee, Shunxing Bao, Yuankai Huo, Bennett A. Landman
Hierarchical transformers (e. g., Swin Transformers) reintroduced several ConvNet priors and further enhanced the practical viability of adapting volumetric segmentation in 3D medical datasets.
1 code implementation • 28 Sep 2022 • Xin Yu, Qi Yang, Yinchi Zhou, Leon Y. Cai, Riqiang Gao, Ho Hin Lee, Thomas Li, Shunxing Bao, Zhoubing Xu, Thomas A. Lasko, Richard G. Abramson, Zizhao Zhang, Yuankai Huo, Bennett A. Landman, Yucheng Tang
Transformer-based models, capable of learning better global dependencies, have recently demonstrated exceptional representation learning capabilities in computer vision and medical image analysis.
1 code implementation • 28 Sep 2022 • Xin Yu, Qi Yang, Yucheng Tang, Riqiang Gao, Shunxing Bao, LeonY. Cai, Ho Hin Lee, Yuankai Huo, Ann Zenobia Moore, Luigi Ferrucci, Bennett A. Landman
External experiments on 20 subjects from the Baltimore Longitudinal Study of Aging (BLSA) dataset that contains longitudinal single abdominal slices validate that our method can harmonize the slice positional variance in terms of muscle and visceral fat area.
no code implementations • 30 Aug 2022 • Tianyuan Yao, Chang Qu, Jun Long, Quan Liu, Ruining Deng, Yuanhan Tian, Jiachen Xu, Aadarsh Jha, Zuhayr Asad, Shunxing Bao, Mengyang Zhao, Agnes B. Fogo, Bennett A. Landman, Haichun Yang, Catie Chang, Yuankai Huo
In order to extract and separate compound figures into usable individual images for downstream learning, we propose a simple compound figure separation (SimCFS) framework without using the traditionally required detection bounding box annotations, with a new loss function and a hard case simulation.
1 code implementation • 15 Aug 2022 • Ruining Deng, Can Cui, Lucas W. Remedios, Shunxing Bao, R. Michael Womick, Sophie Chiron, Jia Li, Joseph T. Roland, Ken S. Lau, Qi Liu, Keith T. Wilson, Yaohong Wang, Lori A. Coburn, Bennett A. Landman, Yuankai Huo
Multi-instance learning (MIL) is widely used in the computer-aided interpretation of pathological Whole Slide Images (WSIs) to solve the lack of pixel-wise or patch-wise annotations.
1 code implementation • 13 Jul 2022 • Kaiwen Xu, Thomas Li, Mirza S. Khan, Riqiang Gao, Sanja L. Antic, Yuankai Huo, Kim L. Sandler, Fabien Maldonado, Bennett A. Landman
We evaluate the validity of the proposed method in automatic BC assessment using lung screening CT with limited FOV.
1 code implementation • 27 Jun 2022 • Ruining Deng, Quan Liu, Can Cui, Tianyuan Yao, Jun Long, Zuhayr Asad, R. Michael Womick, Zheyu Zhu, Agnes B. Fogo, Shilin Zhao, Haichun Yang, Yuankai Huo
The contribution of this paper is three-fold: (1) a novel scale-aware controller is proposed to generalize the dynamic neural network from single-scale to multi-scale; (2) semi-supervised consistency regularization of pseudo-labels is introduced to model the inter-scale correlation of unannotated tissue types into a single end-to-end learning paradigm; and (3) superior scale-aware generalization is evidenced by directly applying a model trained on human kidney images to mouse kidney images, without retraining.
no code implementations • 31 May 2022 • Tianyuan Yao, Yuzhe Lu, Jun Long, Aadarsh Jha, Zheyu Zhu, Zuhayr Asad, Haichun Yang, Agnes B. Fogo, Yuankai Huo
To leverage the performance of the Glo-In-One toolkit, we introduce self-supervised deep learning to glomerular quantification via large-scale web image mining.
no code implementations • 12 May 2022 • Ho Hin Lee, Yucheng Tang, Riqiang Gao, Qi Yang, Xin Yu, Shunxing Bao, James G. Terry, J. Jeffrey Carr, Yuankai Huo, Bennett A. Landman
In this paper, we propose a novel unsupervised approach that leverages pairwise contrast-enhanced CT (CECT) context to compute non-contrast segmentation without ground-truth label.
no code implementations • 25 Mar 2022 • Can Cui, Haichun Yang, Yaohong Wang, Shilin Zhao, Zuhayr Asad, Lori A. Coburn, Keith T. Wilson, Bennett A. Landman, Yuankai Huo
The rapid development of diagnostic technologies in healthcare is leading to higher requirements for physicians to handle and integrate the heterogeneous, yet complementary data that are produced during routine practice.
no code implementations • 8 Mar 2022 • Can Cui, Han Liu, Quan Liu, Ruining Deng, Zuhayr Asad, Yaohong WangShilin Zhao, Haichun Yang, Bennett A. Landman, Yuankai Huo
Thus, there are still open questions on how to effectively predict brain cancer survival from the incomplete radiological, pathological, genomic, and demographic data (e. g., one or more modalities might not be collected for a patient).
no code implementations • 4 Mar 2022 • Xin Yu, Yucheng Tang, Yinchi Zhou, Riqiang Gao, Qi Yang, Ho Hin Lee, Thomas Li, Shunxing Bao, Yuankai Huo, Zhoubing Xu, Thomas A. Lasko, Richard G. Abramson, Bennett A. Landman
Efficiently quantifying renal structures can provide distinct spatial context and facilitate biomarker discovery for kidney morphology.
1 code implementation • 31 Jan 2022 • Yuzhe Lu, Haichun Yang, Zuhayr Asad, Zheyu Zhu, Tianyuan Yao, Jiachen Xu, Agnes B. Fogo, Yuankai Huo
Recent studies have demonstrated the diagnostic and prognostic values of global glomerulosclerosis (GGS) in IgA nephropathy, aging, and end-stage renal disease.
1 code implementation • 13 Jan 2022 • Kaifeng Pang, Zuhayr Asad, Shilin Zhao, Yuankai Huo
Such algorithms can be summarized as (1) patch-level MSI/MSS prediction, and (2) patient-level aggregation.
1 code implementation • 23 Dec 2021 • Ruining Deng, Quan Liu, Can Cui, Zuhayr Asad, Haichun Yang, Yuankai Huo
Computer-assisted quantitative analysis on Giga-pixel pathology images has provided a new avenue in histology examination.
no code implementations • 13 Dec 2021 • Jiachen Xu, Junlin Guo, James Zimmer-Dauphinee, Quan Liu, Yuxuan Shi, Zuhayr Asad, D. Mitchell Wilkes, Parker VanValkenburgh, Steven A. Wernke, Yuankai Huo
Recently, systematic manual survey of satellite and aerial imagery has enabled continuous distributional views of archaeological phenomena at interregional scales.
no code implementations • 8 Dec 2021 • Alessa Hering, Lasse Hansen, Tony C. W. Mok, Albert C. S. Chung, Hanna Siebert, Stephanie Häger, Annkristin Lange, Sven Kuckertz, Stefan Heldmann, Wei Shao, Sulaiman Vesal, Mirabela Rusu, Geoffrey Sonn, Théo Estienne, Maria Vakalopoulou, Luyi Han, Yunzhi Huang, Pew-Thian Yap, Mikael Brudfors, Yaël Balbastre, Samuel Joutard, Marc Modat, Gal Lifshitz, Dan Raviv, Jinxin Lv, Qiang Li, Vincent Jaouen, Dimitris Visvikis, Constance Fourcade, Mathieu Rubeaux, Wentao Pan, Zhe Xu, Bailiang Jian, Francesca De Benetti, Marek Wodzinski, Niklas Gunnarsson, Jens Sjölund, Daniel Grzech, Huaqi Qiu, Zeju Li, Alexander Thorley, Jinming Duan, Christoph Großbröhmer, Andrew Hoopes, Ingerid Reinertsen, Yiming Xiao, Bennett Landman, Yuankai Huo, Keelin Murphy, Nikolas Lessmann, Bram van Ginneken, Adrian V. Dalca, Mattias P. Heinrich
Image registration is a fundamental medical image analysis task, and a wide variety of approaches have been proposed.
1 code implementation • 22 Oct 2021 • Ethan H. Nguyen, Haichun Yang, Ruining Deng, Yuzhe Lu, Zheyu Zhu, Joseph T. Roland, Le Lu, Bennett A. Landman, Agnes B. Fogo, Yuankai Huo
Compared with the conventional bounding box representation, the proposed bounding circle representation innovates in three-fold: (1) it is optimized for ball-shaped biomedical objects; (2) The circle representation reduced the degree of freedom compared with box representation; (3) It is naturally more rotation invariant.
Ranked #1 on
Medical Object Detection
on MoNuSeg 2018
no code implementations • MICCAI Workshop COMPAY 2021 • Shunxing Bao, Yucheng Tang, Ho Hin Lee, Riqiang Gao, Sophie Chiron, Ilwoo Lyu, Lori A. Coburn, Keith T. Wilson, Joseph T. Roland, Bennett A. Landman, Yuankai Huo
Our contribution is three-fold: (1) a single deep network framework is proposed to tackle missing stain in MxIF; (2) the proposed 'N-to-N' strategy reduces theoretical four years of computational time to 20 hours when covering all possible missing stains scenarios, with up to five missing stains (e. g., '(N-1)-to-1', '(N-2)-to-2'); and (3) this work is the first comprehensive experimental study of investigating cross-stain synthesis in MxIF.
no code implementations • 26 Aug 2021 • Cam Nguyen, Zuhayr Asad, Yuankai Huo
For a more comprehensive analysis, we also compare the transformer-based models with six major traditional CNN-based models.
1 code implementation • 27 Jul 2021 • Riqiang Gao, Mirza S. Khan, Yucheng Tang, Kaiwen Xu, Steve Deppen, Yuankai Huo, Kim L. Sandler, Pierre P. Massion, Bennett A. Landman
Image Quality Assessment (IQA) is important for scientific inquiry, especially in medical imaging and machine learning.
no code implementations • 25 Jul 2021 • Riqiang Gao, Yucheng Tang, Kaiwen Xu, Ho Hin Lee, Steve Deppen, Kim Sandler, Pierre Massion, Thomas A. Lasko, Yuankai Huo, Bennett A. Landman
To our knowledge, it is the first generative adversarial model that addresses multi-modal missing imputation by modeling the joint distribution of image and non-image data.
no code implementations • 19 Jul 2021 • Tianyuan Yao, Chang Qu, Quan Liu, Ruining Deng, Yuanhan Tian, Jiachen Xu, Aadarsh Jha, Shunxing Bao, Mengyang Zhao, Agnes B. Fogo, Bennett A. Landman, Catie Chang, Haichun Yang, Yuankai Huo
Our technical contribution is three-fold: (1) we introduce a new side loss that is designed for compound figure separation; (2) we introduce an intra-class image augmentation method to simulate hard cases; (3) the proposed framework enables an efficient deployment to new classes of images, without requiring resource extensive bounding box annotations.
no code implementations • 22 Jun 2021 • Mengyang Zhao, Quan Liu, Aadarsh Jha, Ruining Deng, Tianyuan Yao, Anita Mahadevan-Jansen, Matthew J. Tyska, Bryan A. Millis, Yuankai Huo
Recently, pixel embedding-based cell instance segmentation and tracking provided a neat and generalizable computing paradigm for understanding cellular dynamics.
no code implementations • 3 Jun 2021 • Ho Hin Lee, Yucheng Tang, Qi Yang, Xin Yu, Shunxing Bao, Leon Y. Cai, Lucas W. Remedios, Bennett A. Landman, Yuankai Huo
Medical image segmentation, or computing voxelwise semantic masks, is a fundamental yet challenging task to compute a voxel-level semantic mask.
1 code implementation • 9 Mar 2021 • Quan Liu, Peter C. Louis, Yuzhe Lu, Aadarsh Jha, Mengyang Zhao, Ruining Deng, Tianyuan Yao, Joseph T. Roland, Haichun Yang, Shilin Zhao, Lee E. Wheless, Yuankai Huo
The contribution of the paper is three-fold: (1) The proposed SimTriplet method takes advantage of the multi-view nature of medical images beyond self-augmentation; (2) The method maximizes both intra-sample and inter-sample similarities via triplets from positive pairs, without using negative samples; and (3) The recent mix precision training is employed to advance the training by only using a single GPU with 16GB memory.
no code implementations • 4 Mar 2021 • Yuzhe Lu, Aadarsh Jha, Yuankai Huo
In this paper, we investigate the feasibility of aligning BiT with SimSiam.
1 code implementation • 17 Feb 2021 • Xing Li, Haichun Yang, Jiaxin He, Aadarsh Jha, Agnes B. Fogo, Lee E. Wheless, Shilin Zhao, Yuankai Huo
Reducing outcome variance is an essential task in deep learning based medical image analysis.
1 code implementation • 16 Jan 2021 • Yuzhe Lu, Haichun Yang, Zheyu Zhu, Ruining Deng, Agnes B. Fogo, Yuankai Huo
Different from the recently proposed CutMix method, the CircleMix augmentation is optimized for the ball-shaped biomedical objects, such as glomeruli.
1 code implementation • 4 Jan 2021 • Zekun Wang, Pengwei Wang, Peter C. Louis, Lee E. Wheless, Yuankai Huo
The serverless edge-computing design minimizes the extra hardware costs (e. g., specific devices or cloud computing servers).
no code implementations • 3 Jan 2021 • Quan Liu, Isabella M. Gaeta, Mengyang Zhao, Ruining Deng, Aadarsh Jha, Bryan A. Millis, Anita Mahadevan-Jansen, Matthew J. Tyska, Yuankai Huo
Contribution: The contribution of this paper is three-fold: (1) the proposed method aggregates adversarial simulations and single-stage pixel-embedding based deep learning; (2) the method is assessed with both the cellular (i. e., HeLa cells) and subcellular (i. e., microvilli) objects; and (3) to the best of our knowledge, this is the first study to explore annotation-free instance segmentation and tracking study for microscope videos.
1 code implementation • 23 Dec 2020 • Ho Hin Lee, Yucheng Tang, Shunxing Bao, Richard G. Abramson, Yuankai Huo, Bennett A. Landman
We combine the anatomical prior with corresponding extracted patches to preserve the anatomical locations and boundary information for performing high-resolution segmentation across all organs in a single model.
no code implementations • 23 Dec 2020 • Ho Hin Lee, Yucheng Tang, Kaiwen Xu, Shunxing Bao, Agnes B. Fogo, Raymond Harris, Mark P. de Caestecker, Mattias Heinrich, Jeffrey M. Spraggins, Yuankai Huo, Bennett A. Landman
However, there is no abdominal and retroperitoneal organs atlas framework for multi-contrast CT.
no code implementations • 22 Dec 2020 • Ye Chen, Yuankai Huo
Multi-object tracking (MOT) in computer vision and cell tracking in biomedical image analysis are two similar research fields, whose common aim is to achieve instance level object detection/segmentation and associate such objects across different video frames.
no code implementations • 13 Dec 2020 • Bolin Lai, YuHsuan Wu, Xiaoyu Bai, Xiao-Yun Zhou, Peng Wang, Jinzheng Cai, Yuankai Huo, Lingyun Huang, Yong Xia, Jing Xiao, Le Lu, Heping Hu, Adam Harrison
Using radiological scans to identify liver tumors is crucial for proper patient treatment.
no code implementations • 5 Dec 2020 • Kaiwen Xu, Riqiang Gao, Mirza S. Khan, Shunxing Bao, Yucheng Tang, Steve A. Deppen, Yuankai Huo, Kim L. Sandler, Pierre P. Massion, Mattias P. Heinrich, Bennett A. Landman
For the entire study cohort, the optimized pipeline achieves a registration success rate of 91. 7%.
no code implementations • 2 Nov 2020 • Quan Liu, Isabella M. Gaeta, Mengyang Zhao, Ruining Deng, Aadarsh Jha, Bryan A. Millis, Anita Mahadevan-Jansen, Matthew J. Tyska, Yuankai Huo
Instance object segmentation and tracking provide comprehensive quantification of objects across microscope videos.
1 code implementation • 2 Nov 2020 • Ruining Deng, Quan Liu, Shunxing Bao, Aadarsh Jha, Catie Chang, Bryan A. Millis, Matthew J. Tyska, Yuankai Huo
Our contribution is three-fold: (1) we approach the weakly supervised segmentation from a novel codebook learning perspective; (2) the CaCL algorithm segments diffuse image patterns rather than focal objects; and (3) the proposed algorithm is implemented in a multi-task framework based on Vector Quantised-Variational AutoEncoder (VQ-VAE) via joint image reconstruction, classification, feature embedding, and segmentation.
no code implementations • 22 Oct 2020 • Quan Liu, Isabella M. Gaeta, Bryan A. Millis, Matthew J. Tyska, Yuankai Huo
To match the number of objects at the micro-level, the novel fluorescence-based micro-level matching approach was presented.
no code implementations • 19 Oct 2020 • Riqiang Gao, Yucheng Tang, Kaiwen Xu, Michael N. Kammer, Sanja L. Antic, Steve Deppen, Kim L. Sandler, Pierre P. Massion, Yuankai Huo, Bennett A. Landman
The network can be trained end-to-end with both medical image features and CDEs/biomarkers, or make a prediction with single modality.
no code implementations • 7 Aug 2020 • Bowen Li, Ke Yan, Dar-In Tai, Yuankai Huo, Le Lu, Jing Xiao, Adam P. Harrison
Ultrasound (US) is a critical modality for diagnosing liver fibrosis.
1 code implementation • 28 Jul 2020 • Zheyu Zhu, Yuzhe Lu, Ruining Deng, Haichun Yang, Agnes B. Fogo, Yuankai Huo
Inspired by the recent "human-in-the-loop" strategy, we developed EasierPath, an open-source tool to integrate human physicians and deep learning algorithms for efficient large-scale pathological image quantification as a loop.
1 code implementation • 28 Jul 2020 • Mengyang Zhao, Aadarsh Jha, Quan Liu, Bryan A. Millis, Anita Mahadevan-Jansen, Le Lu, Bennett A. Landman, Matthew J. Tyskac, Yuankai Huo
With both embedding simulation and empirical validation via the four cohorts from the ISBI cell tracking challenge, the proposed Faster Mean-shift algorithm achieved 7-10 times speedup compared to the state-of-the-art embedding based cell instance segmentation and tracking algorithm.
2 code implementations • 7 Jul 2020 • Aadarsh Jha, Haichun Yang, Ruining Deng, Meghan E. Kapp, Agnes B. Fogo, Yuankai Huo
In this paper, we assess if the end-to-end instance segmentation framework is optimal for high-resolution WSI objects by comparing Mask-RCNN with our proposed detect-then-segment framework.
no code implementations • 28 Jun 2020 • Yuankai Huo, Jinzheng Cai, Chi-Tung Cheng, Ashwin Raju, Ke Yan, Bennett A. Landman, Jing Xiao, Le Lu, Chien-Hung Liao, Adam P. Harrison
To this end, we propose a fully-automated and multi-stage liver tumor characterization framework designed for dynamic contrast computed tomography (CT).
1 code implementation • 10 Jun 2020 • Ruining Deng, Haichun Yang, Aadarsh Jha, Yuzhe Lu, Peng Chu, Agnes B. Fogo, Yuankai Huo
However, the 3D identification and association of large-scale glomeruli on renal pathology is challenging due to large tissue deformation, missing tissues, and artifacts from WSI.
1 code implementation • 3 Jun 2020 • Haichun Yang, Ruining Deng, Yuzhe Lu, Zheyu Zhu, Ye Chen, Joseph T. Roland, Le Lu, Bennett A. Landman, Agnes B. Fogo, Yuankai Huo
In this work, we propose CircleNet, a simple anchor-free detection method with circle representation for detection of the ball-shaped glomerulus.
no code implementations • ECCV 2020 • Fengze Liu, Jingzheng Cai, Yuankai Huo, Chi-Tung Cheng, Ashwin Raju, Dakai Jin, Jing Xiao, Alan Yuille, Le Lu, Chien-Hung Liao, Adam P. Harrison
We extensively evaluate our JSSR system on a large-scale medical image dataset containing 1, 485 patient CT imaging studies of four different phases (i. e., 5, 940 3D CT scans with pathological livers) on the registration, segmentation and synthesis tasks.
no code implementations • 17 Mar 2020 • Colin B. Hansen, Vishwesh Nath, Diego A. Mesa, Yuankai Huo, Bennett A. Landman, Thomas A. Lasko
In some learning problems, partial label information can be inferred from otherwise unlabeled examples and used to further improve the model.
no code implementations • 10 Feb 2020 • Yuchen Xu, Olivia Tang, Yucheng Tang, Ho Hin Lee, Yunqiang Chen, Dashan Gao, Shizhong Han, Riqiang Gao, Michael R. Savona, Richard G. Abramson, Yuankai Huo, Bennett A. Landman
We built on a pre-trained 3D U-Net model for abdominal multi-organ segmentation and augmented the dataset either with outlier data (e. g., exemplars for which the baseline algorithm failed) or inliers (e. g., exemplars for which the baseline algorithm worked).
no code implementations • 10 Feb 2020 • Yuchen Xu, Olivia Tang, Yucheng Tang, Ho Hin Lee, Yunqiang Chen, Dashan Gao, Shizhong Han, Riqiang Gao, Michael R. Savona, Richard G. Abramson, Yuankai Huo, Bennett A. Landman
A 2015 MICCAI challenge spurred substantial innovation in multi-organ abdominal CT segmentation with both traditional and deep learning methods.
1 code implementation • 21 Jan 2020 • Jinzheng Cai, Adam P. Harrison, Youjing Zheng, Ke Yan, Yuankai Huo, Jing Xiao, Lin Yang, Le Lu
This is the goal of our work, where we develop a powerful system to harvest missing lesions from the DeepLesion dataset at high precision.
1 code implementation • 16 Dec 2019 • Yiyuan Yang, Riqiang Gao, Yucheng Tang, Sanja L. Antic, Steve Deppen, Yuankai Huo, Kim L. Sandler, Pierre P. Massion, Bennett A. Landman
To improve performance on the primary task, we propose an Internal-Transfer Weighting (ITW) strategy to suppress the loss functions on auxiliary tasks for the final stages of training.
no code implementations • 1 Dec 2019 • Yuankai Huo, Yucheng Tang, Yunqiang Chen, Dashan Gao, Shizhong Han, Shunxing Bao, Smita De, James G. Terry, Jeffrey J. Carr, Richard G. Abramson, Bennett A. Landman
We evaluate the effectiveness of both with and without using soft tissue window normalization on multisite CT cohorts.
no code implementations • 14 Nov 2019 • Yucheng Tang, Ho Hin Lee, Yuchen Xu, Olivia Tang, Yunqiang Chen, Dashan Gao, Shizhong Han, Riqiang Gao, Camilo Bermudez, Michael R. Savona, Richard G. Abramson, Yuankai Huo, Bennett A. Landman
Dynamic contrast enhanced computed tomography (CT) is an imaging technique that provides critical information on the relationship of vascular structure and dynamics in the context of underlying anatomy.
no code implementations • 12 Nov 2019 • Riqiang Gao, Lingfeng li, Yucheng Tang, Sanja L. Antic, Alexis B. Paulson, Yuankai Huo, Kim L. Sandler, Pierre P. Massion, Bennett A. Landman
Annual low dose computed tomography (CT) lung screening is currently advised for individuals at high risk of lung cancer (e. g., heavy smokers between 55 and 80 years old).
no code implementations • 12 Nov 2019 • Ho Hin Lee, Yucheng Tang, Olivia Tang, Yuchen Xu, Yunqiang Chen, Dashan Gao, Shizhong Han, Riqiang Gao, Michael R. Savona, Richard G. Abramson, Yuankai Huo, Bennett A. Landman
The contributions of the proposed method are threefold: We show that (1) the QA scores can be used as a loss function to perform semi-supervised learning for unlabeled data, (2) the well trained discriminator is learnt by QA score rather than traditional true/false, and (3) the performance of multi-organ segmentation on unlabeled datasets can be fine-tuned with more robust and higher accuracy than the original baseline method.
no code implementations • 11 Sep 2019 • Riqiang Gao, Yuankai Huo, Shunxing Bao, Yucheng Tang, Sanja L. Antic, Emily S. Epstein, Aneri B. Balar, Steve Deppen, Alexis B. Paulson, Kim L. Sandler, Pierre P. Massion, Bennett A. Landman
To model both regular and irregular longitudinal samples, we generalize the LSTM model with the Distanced LSTM (DLSTM) for temporally varied acquisitions.
no code implementations • 13 Aug 2019 • Camilo Bermudez, Justin Blaber, Samuel W. Remedios, Jess E. Reynolds, Catherine Lebel, Maureen McHugo, Stephan Heckers, Yuankai Huo, Bennett A. Landman
Generalizability is an important problem in deep neural networks, especially in the context of the variability of data acquisition in clinical magnetic resonance imaging (MRI).
no code implementations • 15 Jul 2019 • Vishwesh Nath, Ilwoo Lyu, Kurt G. Schilling, Prasanna Parvathaneni, Colin B. Hansen, Yucheng Tang, Yuankai Huo, Vaibhav A. Janve, Yurui Gao, Iwona Stepniewska, Adam W. Anderson, Bennett A. Landman
In the in-vivo human data, Deep SHORE was more consistent across scanners with 0. 63 relative to other multi-shell methods 0. 39, 0. 52 and 0. 57 in terms of ACC.
1 code implementation • 23 Jun 2019 • Yuankai Huo, James G. Terry, Jiachen Wang, Sangeeta Nair, Thomas A. Lasko, Barry I. Freedman, J. Jeffery Carr, Bennett A. Landman
Manually tracing regions of interest (ROIs) within the liver is the de facto standard method for measuring liver attenuation on computed tomography (CT) in diagnosing nonalcoholic fatty liver disease (NAFLD).
2 code implementations • 28 Mar 2019 • Yuankai Huo, Zhoubing Xu, Yunxi Xiong, Katherine Aboud, Prasanna Parvathaneni, Shunxing Bao, Camilo Bermudez, Susan M. Resnick, Laurie E. Cutting, Bennett A. Landman
To address the first challenge, multiple spatially distributed networks were used in the SLANT method, in which each network learned contextual information for a fixed spatial location.
no code implementations • 21 Feb 2019 • Jiachen Wang, Riqiang Gao, Yuankai Huo, Shunxing Bao, Yunxi Xiong, Sanja L. Antic, Travis J. Osterman, Pierre P. Massion, Bennett A. Landman
The results show that the AUC obtained from clinical demographics alone was 0. 635 while the attention network alone reached an accuracy of 0. 687.
no code implementations • 7 Jan 2019 • Yunxi Xiong, Yuankai Huo, Jiachen Wang, L. Taylor Davis, Maureen McHugo, Bennett A. Landman
Recently, we obtained a clinically acquired, multi-sequence MRI brain cohort with 1480 clinically acquired, de-identified brain MRI scans on 395 patients using seven different MRI protocols.
no code implementations • 10 Dec 2018 • Cailey I. Kerley, Yuankai Huo, Shikha Chaganti, Shunxing Bao, Mayur B. Patel, Bennett A. Landman
For instance, in a typical sample of clinical TBI imaging cohort, only ~15% of CT scans actually contain whole brain CT images suitable for volumetric brain analyses; the remaining are partial brain or non-brain images.
no code implementations • 26 Nov 2018 • Camilo Bermudez, William Rodriguez, Yuankai Huo, Allison E. Hainline, Rui Li, Robert Shults, Pierre D. DHaese, Peter E. Konrad, Benoit M. Dawant, Bennett A. Landman
We show an improvement in the classification of intraoperative stimulation coordinates as a positive response in reduction of symptoms with AUC of 0. 670 compared to a baseline registration-based approach, which achieves an AUC of 0. 627 (p < 0. 01).
no code implementations • 10 Nov 2018 • Yuankai Huo, James G. Terry, Jiachen Wang, Vishwesh Nath, Camilo Bermudez, Shunxing Bao, Prasanna Parvathaneni, J. Jeffery Carr, Bennett A. Landman
From the results, the proposed AID-Net achieved the superior performance on classification accuracy (0. 9272) and AUC (0. 9627).
no code implementations • 9 Nov 2018 • Yuankai Huo, Zhoubing Xu, Shunxing Bao, Camilo Bermudez, Hyeonsoo Moon, Prasanna Parvathaneni, Tamara K. Moyo, Michael R. Savona, Albert Assad, Richard G. Abramson, Bennett A. Landman
A clinically acquired cohort containing both T1-weighted (T1w) and T2-weighted (T2w) MRI splenomegaly scans was used to train and evaluate the performance of multi-atlas segmentation (MAS), 2D DCNN networks, and a 3D DCNN network.
1 code implementation • 15 Oct 2018 • Yuankai Huo, Zhoubing Xu, Hyeonsoo Moon, Shunxing Bao, Albert Assad, Tamara K. Moyo, Michael R. Savona, Richard G. Abramson, Bennett A. Landman
SynSeg-Net is trained by using (1) unpaired intensity images from source and target modalities, and (2) manual labels only from source modality.
no code implementations • 6 Jun 2018 • Yuankai Huo, Katherine Swett, Susan M. Resnick, Laurie E. Cutting, Bennett A. Landman
By indexing the dictionary, the whole brain probabilistic atlases adapt to each new subject quickly and can be used as spatial priors for visualization and processing.
2 code implementations • 1 Jun 2018 • Yuankai Huo, Zhoubing Xu, Katherine Aboud, Prasanna Parvathaneni, Shunxing Bao, Camilo Bermudez, Susan M. Resnick, Laurie E. Cutting, Bennett A. Landman
Whole brain segmentation on a structural magnetic resonance imaging (MRI) is essential in non-invasive investigation for neuroanatomy.
no code implementations • 25 May 2018 • Zhoubing Xu, Yuankai Huo, Jin-Hyeong Park, Bennett Landman, Andy Milkowski, Sasa Grbic, Shaohua Zhou
However, this is a challenging problem given not only the inherent difficulties from the ultrasound modality, e. g., low contrast and large variations, but also the heterogeneity across tasks, i. e., one classification task for all views, and then one landmark detection task for each relevant view.
1 code implementation • 20 Dec 2017 • Yuankai Huo, Zhoubing Xu, Shunxing Bao, Albert Assad, Richard G. Abramson, Bennett A. Landman
Herein, we proposed a novel end-to-end synthesis and segmentation network (EssNet) to achieve the unpaired MRI to CT image synthesis and CT splenomegaly segmentation simultaneously without using manual labels on CT.
no code implementations • 2 Dec 2017 • Yuankai Huo, Shunxing Bao, Prasanna Parvathaneni, Bennett A. Landman
Herein, the MaCRUISE surface parcellation (MaCRUISEsp) method is proposed to perform the surface parcellation upon the inner, central and outer surfaces that are reconstructed from MaCRUISE.
1 code implementation • 2 Dec 2017 • Yuankai Huo, Zhoubing Xu, Shunxing Bao, Camilo Bermudez, Andrew J. Plassard, Jiaqi Liu, Yuang Yao, Albert Assad, Richard G. Abramson, Bennett A. Landman
However, variations in both size and shape of the spleen on MRI images may result in large false positive and false negative labeling when deploying DCNN based methods.
no code implementations • 29 Aug 2017 • Yuankai Huo, Susan M. Resnick, Bennett A. Landman
(2) The proposed algorithm is a longitudinal generalization of a lead-ing joint label fusion method (JLF) that has proven adaptable to a wide variety of applications.