Search Results for author: Yushuai Wu

Found 4 papers, 1 papers with code

Structure-Based Molecule Optimization via Gradient-Guided Bayesian Update

no code implementations20 Nov 2024 Keyue Qiu, Yuxuan Song, Jie Yu, Hongbo Ma, Ziyao Cao, Zhilong Zhang, Yushuai Wu, Mingyue Zheng, Hao Zhou, Wei-Ying Ma

Structure-based molecule optimization (SBMO) aims to optimize molecules with both continuous coordinates and discrete types against protein targets.

Bayesian Inference Drug Design

LangCell: Language-Cell Pre-training for Cell Identity Understanding

3 code implementations9 May 2024 Suyuan Zhao, Jiahuan Zhang, Yushuai Wu, Yizhen Luo, Zaiqing Nie

Cell identity encompasses various semantic aspects of a cell, including cell type, pathway information, disease information, and more, which are essential for biologists to gain insights into its biological characteristics.

DeepCRE: Transforming Drug R&D via AI-Driven Cross-drug Response Evaluation

no code implementations6 Mar 2024 Ting Zhang, Hao Zhou, Hainan Wu, Hanwen Sunchu, Lei Hu, Xiaofang Chen, Suyuan Zhao, Gaochao liu, Chao Sun, Jiahuan Zhang, Yizhen Luo, Peng Liu, Zaiqing Nie, Yushuai Wu

The fields of therapeutic application and drug research and development (R&D) both face substantial challenges, i. e., the therapeutic domain calls for more treatment alternatives, while numerous promising pre-clinical drugs have failed in clinical trials.

Towards Unified AI Drug Discovery with Multiple Knowledge Modalities

no code implementations17 Apr 2023 Yizhen Luo, Xing Yi Liu, Kai Yang, Kui Huang, Massimo Hong, Jiahuan Zhang, Yushuai Wu, Zaiqing Nie

In recent years, AI models that mine intrinsic patterns from molecular structures and protein sequences have shown promise in accelerating drug discovery.

Drug Discovery Knowledge Graphs +2

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