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The CRC dataset contains 1133 colorectal biopsy and polypectomy slides and is the result of our ongoing efforts to contribute to CRC diagnosis with a reference dataset. We aim to detect high-grade lesions with high sensitivity. High-grade lesions encompass conventional adenomas with high-grade dysplasia (including intra-mucosal carcinomas) and invasive adenocarcinomas. In addition, we also intend to identify low-grade lesions (corresponding to conventional adenomas with low-grade dysplasia). Accordingly, we created three diagnostic categories for the algorithm, labelled as non-neoplastic, low-grade and high-grade lesions.