Accurate De Novo Prediction of Protein Contact Map by Ultra-Deep Learning Model

2 Sep 2016Sheng WangSiqi SunZhen LiRenyu ZhangJinbo Xu

Recently exciting progress has been made on protein contact prediction, but the predicted contacts for proteins without many sequence homologs is still of low quality and not very useful for de novo structure prediction. This paper presents a new deep learning method that predicts contacts by integrating both evolutionary coupling (EC) and sequence conservation information through an ultra-deep neural network formed by two deep residual networks... (read more)

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