Distant supervision assumes that any sentence containing the same entity pairs reflects identical relationships. Previous works of distantly supervised relation extraction (DSRE) task generally focus on sentence-level or bag-level de-noising techniques independently, neglecting the explicit interaction with cross levels. In this paper, we propose a hierarchical contrastive learning Framework for Distantly Supervised relation extraction (HiCLRE) to reduce noisy sentences, which integrate the global structural information and local fine-grained interaction. Specifically, we propose a three-level hierarchical learning framework to interact with cross levels, generating the de-noising context-aware representations via adapting the existing multi-head self-attention, named Multi-Granularity Recontextualization. Meanwhile, pseudo positive samples are also provided in the specific level for contrastive learning via a dynamic gradient-based data augmentation strategy, named Dynamic Gradient Adversarial Perturbation. Experiments demonstrate that HiCLRE significantly outperforms strong baselines in various mainstream DSRE datasets.