Regulating the Hydrophobic Domain in Peptide-Catecholamine Coassembled Nanostructures for Fluorescence Enhancement

3 Jul 2023  ·  Ruoyang Zhao, Feng Gao, Maoyu Li, Xingkun Niu, Shihao Liu, Xinmin Zhao, Liping Wang, Jun Guo, Feng Zhang ·

Hydrophobic domains provide specific microenvironment for essential functional activities in life. Herein, we studied how the coassembling of peptides with catecholamines regulate the hydrophobic domain-containing nanostructures for fluorescence enhancement. By peptide encoding and coassembling with catecholamines of different hydrophilicities, a series of hierarchical assembling systems were constructed. In combination with molecular dynamics simulation, we experimentally discovered the hydrophobic domain of chromophore microenvironment regulates the fluorescence of coassembled nanostructures. Our results shed light on the rational design of fluorescent bio-coassembled nanoprobes for biomedical applications.

PDF Abstract
No code implementations yet. Submit your code now

Tasks


Datasets


  Add Datasets introduced or used in this paper

Results from the Paper


  Submit results from this paper to get state-of-the-art GitHub badges and help the community compare results to other papers.

Methods


No methods listed for this paper. Add relevant methods here